Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jennifer C Sasaki"'
Autor:
Yauheniya Cherkas, Michael K. McMillian, Dhammika Amaratunga, Nandini Raghavan, Jennifer C. Sasaki
Publikováno v:
Toxicology Reports, Vol 3, Iss , Pp 252-261 (2016)
As legacy toxicogenomics databases have become available, improved data mining approaches are now key to extracting and visualizing subtle relationships between toxicants and gene expression. In the present study, a novel “aggregating bundles of cl
Externí odkaz:
https://doaj.org/article/aad297a1c8d14f82ab1844ff388aea3c
Autor:
Véronique Thybaud, Kerry L. Dearfield, Roland Froetschl, Jennifer C. Sasaki, Mirjam Luijten, George E. Johnson, John Nicolette, Michelle R. Embry, Laura Custer, Gladys Ouedraogo, Raja S. Settivari
Publikováno v:
Environmental and Molecular Mutagenesis. 62:512-525
We present a hypothetical case study to examine the use of a next-generation framework developed by the Genetic Toxicology Technical Committee of the Health and Environmental Sciences Institute for assessing the potential risk of genetic damage from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94a80d1984a7afa084ed6b9f60639c4
https://doi.org/10.1002/em.22467
https://doi.org/10.1002/em.22467
Autor:
Danna Jennings, Sarah Huntwork-Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, René Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo D. Maciuca, Laura Harris, Angela Kay, Peter LeWitt, T. Alex King, Drew Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang Nguyen, Kimberly Scearce-Levie, Carole Ho, Matthew D. Troyer
Publikováno v:
Science Translational Medicine. 14
Mutations in leucine-rich repeat kinase 2 ( LRRK2 ) are the most common genetic risk factors for Parkinson’s disease (PD). Increased LRRK2 kinase activity is thought to impair lysosomal function and may contribute to the pathogenesis of PD. Thus, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d447b718b56152fa35afc4ad299bcf
https://doi.org/10.1126/scitranslmed.abj2658
https://doi.org/10.1126/scitranslmed.abj2658
Autor:
John Nicolette, Donald P. Quigley, Alejandra Trejo-Martin, David Woolley, Lidiya Stavitskaya, Lennart T. Anger, Dave Bower, Jennifer C. Sasaki, Candice Y. Johnson, Michelle O. Kenyon, Glenn J. Myatt, Sandy Weiner, Naomi L. Kruhlak, Susanne Glowienke, Véronique Gervais, Lisa Beilke, Angela White, Penny Leavitt, Roxanne Andaya, James Harvey, Joel P. Bercu, Andrew Teasdale, Jacky Van Gompel, Raymond Kemper, Kevin P. Cross, Scott Miller, Catrin Hasselgren, Barber Christopher Gordon, M. Vijayaraj Reddy, Joerg Wichard, Robert A. Jolly, Alessandro Brigo, Dennie S. Welch, Alexander Amberg, Russell Naven, Masamitsu Honma, Alexis Parenty, Stephen Gomez, Zoryanna Cammerer, Mark Powley, Laura Custer, Krista L. Dobo, Helga Gerets, Wolfgang Muster
Publikováno v:
Regulatory toxicology and pharmacology : RTP
The International Council for Harmonization (ICH) M7 guideline describes a hazard assessment process for impurities that have the potential to be present in a drug substance or drug product. In the absence of adequate experimental bacterial mutagenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc40f205a6b475a7fdd8889147e338e1
https://doi.org/10.1016/j.yrtph.2018.12.007
https://doi.org/10.1016/j.yrtph.2018.12.007
Autor:
Steven M. Bryce, Laura Custer, Kerry L. Dearfield, Carole L. Yauk, Giel Hendriks, Ashley Allemang, Sheila M. Galloway, Maik Schuler, Stefan Pfuhler, Patricia A Escobar, Azeddine Elhajouji, Gladys Ouedraogo, Albert J. Fornace, Heng-Hong Li, Jennifer C. Sasaki, Daniel J Roberts, Yasmin Dietz, Ulrike Hemmann, Jan van Benthem, Véronique Thybaud, Roland Froetschl, Lauren Peel, Mirjam Luijten
In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94120698a05b8acf2acfae209b20a2b1
http://hdl.handle.net/10029/623463
http://hdl.handle.net/10029/623463
Autor:
Jennifer C. Sasaki, Nandini Raghavan, Michael McMillian, Dhammika Amaratunga, Yauheniya Cherkas
Publikováno v:
Scipedia Open Access
Scipedia SL
Toxicology Reports, Vol 3, Iss, Pp 252-261 (2016)
Toxicology Reports
Scipedia SL
Toxicology Reports, Vol 3, Iss, Pp 252-261 (2016)
Toxicology Reports
As legacy toxicogenomics databases have become available, improved data mining approaches are now key to extracting and visualizing subtle relationships between toxicants and gene expression. In the present study, a novel “aggregating bundles of cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7731f24198dca4f8cab39869c5356be
https://doi.org/10.1016/j.toxrep.2016.01.009
https://doi.org/10.1016/j.toxrep.2016.01.009
Autor:
Harish Shankaran, Abhishek G. Sathe, Jennifer C. Sasaki, Aixiang Xue, Per E. Andrén, Selvi Pradeepan, Anna Nilsson, Richard J. A. Goodwin, Natalie Keirstead, Anshul Gupta, Richard T. Gallagher, John G. Swales
Publikováno v:
Chemical Research in Toxicology. 28:1823-1830
Colistin and polymyxin B are effective treatment options for Gram-negative resistant bacteria but are used as last-line therapy due to their dose-limiting nephrotoxicity. A critical factor in developing safer polymyxin analogues is understanding accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6815c5fe363edb205bfddb745649e05
https://doi.org/10.1021/acs.chemrestox.5b00262
https://doi.org/10.1021/acs.chemrestox.5b00262
Autor:
Marie Blais, Douglas Ferguson, Mark Pietras, Jim Fikes, Abhishek G. Sathe, Sally A. Price, Anshul Gupta, Melanie Galvin, Michael R. Hale, Robert L. Walsky, Yvonne P. Dragan, Frank McGrath, Crystal Brown, Paul J. Ciaccio, Gunther Kern, Matthew Wagoner, Letitia Cheatham, Nakpangi Johnson, Patricia Bentley, Natalie Keirstead, Debra Snow, Wenli Luo, Jennifer C. Sasaki
Publikováno v:
Toxicological Sciences. 137:278-291
Despite six decades of clinical experience with the polymyxin class of antibiotics, their dose-limiting nephrotoxicity remains difficult to predict due to a paucity of sensitive biomarkers. Here, we evaluate the performance of standard of care and ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e7ce12b5cc757b27009c075c2c9b9d
https://doi.org/10.1093/toxsci/kft247
https://doi.org/10.1093/toxsci/kft247
Autor:
Wim Bert Griet Schepens, Judith Eva Baumeister, Tim H. M. Jonckers, Geerwin Yvonne Paul Haché, Sabine Hallenberger, Marie-Claude Rouan, Jennifer C. Sasaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4998-5002
A new class of benzoxazole and benzothiazole amide derivatives exhibiting potent CYP3A4 inhibiting properties was identified. Extensive lead optimization was aimed at improving the CYP3A4 inhibitory properties as well as overall ADME profile of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2d88d0d5d3ea91fb98899e19d056b0
https://doi.org/10.1016/j.bmcl.2012.06.022
https://doi.org/10.1016/j.bmcl.2012.06.022
Autor:
Jennifer C. Sasaki, Monica Seger, James H. Kim, Louise Parks Saldutti, Robert E. Chapin, Brian P. Enright, Keith Jarvi, David Gregory Hall, Mary L. Hixon, Jeffrey S. Moffit, William J. Breslin, Terri Mitchard
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:511-525
BACKGROUND: Testicular toxicity (TT) is a sporadic and challenging issue in pharmaceutical drug development. Efforts to develop TT screening assays or biomarkers have been overshadowed by consortium efforts to predict drug-induced toxicities such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc543787a7276fd3f89d203d2dd4c7f
https://doi.org/10.1002/bdrb.20338
https://doi.org/10.1002/bdrb.20338