Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jennifer C, Regan"'
Autor:
Mary-Kate Corbally, Jennifer C. Regan
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/bb6f1e9a7e6046ba8972cc403e5a6435
Autor:
Yu-Xuan Lu, Jennifer C Regan, Jacqueline Eßer, Lisa F Drews, Thomas Weinseis, Julia Stinn, Oliver Hahn, Richard A Miller, Sebastian Grönke, Linda Partridge
Publikováno v:
eLife, Vol 10 (2021)
Age-related changes to histone levels are seen in many species. However, it is unclear whether changes to histone expression could be exploited to ameliorate the effects of ageing in multicellular organisms. Here we show that inhibition of mTORC1 by
Externí odkaz:
https://doaj.org/article/3f56fa13c9084ce2af608dbcc1b3da37
Autor:
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne M Toivonen, Michael P Murphy, Janet Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009083 (2020)
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its
Externí odkaz:
https://doaj.org/article/c18379ac1b6a41b382dffb438dd7eff6
Autor:
Jennifer C. Regan, Yu-Xuan Lu, Enric Ureña, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Publikováno v:
Regan, J C, Lu, Y X, Ureña, E, Meilenbrock, R L, Catterson, J H, Kißler, D, Fröhlich, J, Funk, E & Partridge, L 2022, ' Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin ', Nature Aging, vol. 2, no. 12, pp. 1145-1158 . https://doi.org/10.1038/s43587-022-00308-7
Nature Aging
Nature aging
Nature Aging
Nature aging
Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097e8dde5d4949beb131caf9b20b0d04
https://doi.org/10.1038/s43587-022-00308-7
https://doi.org/10.1038/s43587-022-00308-7
Autor:
Ekin Bolukbasi, Mobina Khericha, Jennifer C. Regan, Dobril K. Ivanov, Jennifer Adcott, Miranda C. Dyson, Tobias Nespital, Janet M. Thornton, Nazif Alic, Linda Partridge
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 641-653 (2017)
Reduced activity of nutrient-sensing signaling networks can extend organismal lifespan, yet the underlying biology remains unclear. We show that the anti-aging effects of rapamycin and reduced intestinal insulin/insulin growth factor (IGF) signaling
Externí odkaz:
https://doaj.org/article/cce15e3e52c04e6f8d87a794625c2bc3
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The sexes show profound differences in responses to infection and the development of autoimmunity. Dimorphisms in immune responses are ubiquitous across taxa, from arthropods to vertebrates. Drosophila melanogaster shows strong sex dimorphisms in imm
Externí odkaz:
https://doaj.org/article/24130c4f93df409a985b8570f0270363
Autor:
Jennifer C Regan, Mobina Khericha, Adam J Dobson, Ekin Bolukbasi, Nattaphong Rattanavirotkul, Linda Partridge
Publikováno v:
eLife, Vol 5 (2016)
Women live on average longer than men but have greater levels of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila. The intestinal epithelium of the aging female undergoes major deteri
Externí odkaz:
https://doaj.org/article/c0ec6175f0ac431884dc8ed3cd72c0d8
Autor:
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side-effects from continuous dosing regimes. Here we show a profound memory effect of brief, early rapamycin treatment of adults, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453c437a573e21ae683f8624dcbc6785
https://doi.org/10.1101/2022.04.20.488884
https://doi.org/10.1101/2022.04.20.488884
Autor:
Jennifer C. Regan, Linda Partridge, Ralf Leslie Meilenbrock, Disna Kissler, Enric Urena, Yu-Xuan Lu, J. H. Catterson
Pharmacological attenuation of mTOR by rapamycin and other compounds presents a promising route for delay of ageing-related pathologies, including intestinal cancers. Here, we show that rapamycin treatment in Drosophila extends lifespan in females bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12a7040db7207d39eb3cd1047990f462
https://doi.org/10.1101/2021.10.22.465415
https://doi.org/10.1101/2021.10.22.465415
Publikováno v:
Regan, J, Froy, H, Walling, C, Moatt, J & Nussey, D 2019, ' Dietary restriction and insulin-like signalling pathways as adaptive plasticity : A synthesis and re-evaluation ', Functional Ecology, vol. 34, no. 1 . https://doi.org/10.1111/1365-2435.13418
Dietary restriction (DR) under laboratory conditions generally extends life span and delays ageing across species as diverse as yeast, nematode worms, flies and mice, and is underpinned by taxonomically conserved physiological pathways, notably the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b945ad03e0b2feaf2b7d075954d7ac
https://doi.org/10.1111/1365-2435.13418
https://doi.org/10.1111/1365-2435.13418