Výsledky vyhledávání - "Jennifer C, Byrne"

Akademický článek

Btk regulates macrophage polarization in response to lipopolysaccharide.

Autor: Joan Ní Gabhann, Emily Hams, Siobhán Smith, Claire Wynne, Jennifer C Byrne, Kiva Brennan, Shaun Spence, Adrien Kissenpfennig, James A Johnston, Padraic G Fallon, Caroline A Jefferies

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85834 (2014)

Bacterial Lipopolysaccharide (LPS) is a strong inducer of inflammation and does so by inducing polarization of macrophages to the classic inflammatory M1 population. Given the role of Btk as a critical signal transducer downstream of TLR4, we investi

Externí odkaz: https://doaj.org/article/17235ee57bfe419fa6d88dfce75b4939

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Akademický článek

Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease

Autor: Jennifer C. Byrne, Joan Ní Gabhann, Elisa Lazzari, Rebecca Mahony, Siobhán Smith, Kevin Stacey, Claire Wynne, Caroline A. Jefferies

Publikováno v: Clinical and Developmental Immunology, Vol 2012 (2012)

Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was fir

Externí odkaz: https://doaj.org/article/2126a4e9a9064fe8a8904e35fda5ea07

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Estrogen Receptor α Regulates Tripartite Motif-Containing Protein 21 Expression, Contributing to Dysregulated Cytokine Production in Systemic Lupus Erythematosus

Autor: Grainne Kearns, Rebecca Mahony, Eoghan M. McCarthy, Siobhán Smith, Kevin Stacey, Brian J. Harvey, Elizabeth Ball, Caroline A. Jefferies, Michele F. Doran, Jennifer C. Byrne, Ruth Z Lee, Eamonn S. Molloy, Barbara M. Coffey, Joan Ní Gabhann, Gaye Cunnane, Aubrey L. Bell

Publikováno v: Arthritis & Rheumatology. 66:163-172

Objective To examine the role of 17β-estradiol in the regulation of the autoantigen tripartite motif–containing protein 21 (TRIM-21) in patients with systemic lupus erythematosus (SLE). Methods Monocytes isolated from healthy control subjects and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38b3fce55f13baf671823524a80563fe
https://doi.org/10.1002/art.38187

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Bruton's Tyrosine Kinase Is Required for Apoptotic Cell Uptake via Regulating the Phosphorylation and Localization of Calreticulin

Autor: Warren Thomas, Kevin Stacey, Eoghan M. McCarthy, Joan Ní Gabhann, Caroline A. Jefferies, Jennifer C. Byrne, Barbara M. Coffey

Publikováno v: The Journal of Immunology. 190:5207-5215

In addition to regulating B cell development and activation, Bruton’s tyrosine kinase (Btk) functions downstream of multiple TLRs, including TLR7, to regulate innate immune responses in myeloid cells. Although critical for defense against RNA virus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60326297f96c901684697fb80f84f16
https://doi.org/10.4049/jimmunol.1300057

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Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-κB signaling in neurons

Autor: Jochen H. M. Prehn, Hans-Georg König, Caroline A. Jefferies, Jennifer C. Byrne, Robert Schwamborn, Beau J. Fenner, Tytus Bernas

Publikováno v: Journal of Cell Science. 125:6058-6070

Summary Neuronal survival and plasticity critically depend on constitutive activity of the transcription factor nuclear factor-κB (NF-κB). We here describe a role for a small intracellular fibroblast growth factor homologue, the fibroblast growth f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2db11f91c31b73c20849060b3065ba
https://doi.org/10.1242/jcs.111880

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Glycomic and Glycoproteomic Analysis of Serum from Patients with Stomach Cancer Reveals Potential Markers Arising from Host Defense Response Mechanisms

Autor: Jennifer C. Byrne, Herve Boissin, Caitriona Scaife, Pauline M. Rudd, Jonathan Bones, Anca Nastase, Niaobh O'Donoghue, Ciara A. McManus

Publikováno v: Journal of Proteome Research. 10:1246-1265

Despite the reduced incidence of gastric cancer in the developed world, a diagnosis of stomach carcinoma still carries a poor prognosis due to the asymptomatic nature of the disease in the early stages, subsequent advanced stage diagnosis, and a low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ab695cad2dc3006cc411ac31f5572f
https://doi.org/10.1021/pr101036b

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Galactosemia, a Single Gene Disorder With Epigenetic Consequences

Autor: Peter D Doran, Pauline M. Rudd, David W. Murray, Jennifer C. Byrne, David Coman, Eileen P. Treacy, Paola M Bagaglia

Publikováno v: Pediatric Research. 67:286-292

Long-term outcomes of classic galactosemia (GAL) remain disappointing. It is unclear if the complications result mainly from prenatal-neonatal toxicity or persistent glycoprotein and glycolipid synthesis abnormalities. We performed gene expression pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a501df27b9f90d6ade6d936effc1f7e
https://doi.org/10.1203/pdr.0b013e3181cbd542

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Detecting soluble Clusterin in in-vitro and in-vivo models of prostate cancer

Autor: F P Girard, Jennifer C. Byrne, F Desgrandchamps, Michelle R Downes, R.W.G. Watson, John M. Fitzpatrick, D.M. Fanning

Publikováno v: Neoplasma. 57:488-493

PSA, the only relevant marker for prostate cancer, has a low predictive value; moreover its low threshold leads to unnecessary biopsies with associated complications. Identification of prognostic factors is an important goal in prostate cancer. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98bf8bf812dfa03d454c9076ed62009a
https://doi.org/10.4149/neo_2010_05_488

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