Effect of Trichostatin A on miRNA expression in cultures of primary rat hepatocytes

Autor: Daneida Lizarraga, Joost H.M. van Delft, Tamara Vanhaecke, Jennifer Bolleyn, Joanna Fraczek, Vera Rogiers, Stan Gaj, Mathieu Vinken

Publikováno v: Vrije Universiteit Brussel
Toxicology in Vitro, 25(6), 1173-1182. Elsevier Science

In the present study, the effect of Trichostatin A (TSA), a histone deacetylase inhibitor, was investigated on the microRNA (miR, miRNA) expression profile in cultured primary rat hepatocytes by means of microarray analysis. Simultaneously, albumin s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df42eb1164469e62b74f1743efd5061b
https://doi.org/10.1016/j.tiv.2011.04.013

Epigenetic Modifications as Antidedifferentiation Strategy for Primary Hepatocytes in Culture

Autor: Jennifer, Bolleyn, Joanna, Fraczek, Vera, Rogiers, Tamara, Vanhaecke

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1250

A well-known problem of cultured primary hepatocytes is their rapid dedifferentiation. During the last years, several strategies to counteract this phenomenon have been developed, of which changing the in vitro environment is the most popular one. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c20654e4f526e8b0e511c9e6896afd2e
https://pubmed.ncbi.nlm.nih.gov/26272144

MicroRNAs as key regulators of xenobiotic biotransformation and drug response

Autor: Vera Rogiers, Joery De Kock, Tamara Vanhaecke, Mathieu Vinken, Robim Marcelino Rodrigues, Jennifer Bolleyn

In the last decade, microRNAs have emerged as key factors that negatively regulate mRNA expression. It has been estimated that more than 50% of protein-coding genes are under microRNA control and each microRNA is predicted to repress several mRNA tar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad682921bbd479250b8f0dfbc093b31c
https://biblio.vub.ac.be/vubir/micrornas-as-key-regulators-of-xenobiotic-biotransformation-and-drug-response(64210a57-6c67-4c38-880b-e4d62690658f).html

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Autor: Kathrin Schmich, Christoph Meyer, Steven Dooley, Gerd A. Kullak-Ublick, Daniel J. Maltman, Ernst H. K. Stelzer, Jessica Mwinyi, Valentina Fonsato, Albert Braeuning, Melvin E. Andersen, María José Gómez-Lechón, Georg Damm, Philip Hewitt, J. Craig Rowlands, Jingbo Pi, Lena Gustavsson, Chong Su Cho, Stefan Przyborski, Thomas S. Weiss, Joanna Fraczek, Ute Albrecht, Regina Stöber, Britta Burkhardt, Adam S. Hayward, Sudin Bhattacharya, Bruno Stieger, Tamara Vanhaecke, Cliff Rowe, Kathy Yarborough, Celine Schelcher, Neil R. Cameron, Andreas K. Nussler, Seddik Hammad, Rowena Eakins, Olaf Dirsch, Dean J. Naisbitt, Dieter Häussinger, Robert A. Budinsky, Karine Sá Ferreira, Christopher E. Goldring, Jennifer Luebke-Wheeler, Giovanni Camussi, J. Brian Houston, Jennifer Bolleyn, Andrew Gibson, Patrick D. McMullen, Hermann-Georg Holzhütter, Michael Schwarz, Peng Lu, Jens M. Kelm, Francesco Pampaloni, Christelle Guyot, Jens Hrach, Uta Dahmen, J Böttger, Nicola J. Hewitt, Bijay Singh, Verena Keitel, Christoph Borner, Yuichi Sugiyama, Anna Lutz, Edward L. LeCluyse, Patricio Godoy, Simon Messner, Dirk Drasdo, Nariman Ansari, Courtney G. Woods, Irmgard Merfort, Rolf Gebhardt, María Teresa Donato, Yun Jaie Choi, Claus Kordes, B. Kevin Park, Jan G. Hengstler, Jinghai James Xu, Stefan Hoehme, Claus Hellerbrand, Peter Olinga, Hartmut Jaeschke, Linda J. Pluta, Agata Widera, Johannes G. Bode, Anup Ramachandran, Kiyomi Ito, Matthias Glanemann, David Hallifax, Geny M. M. Groothuis, Wolfgang E. Thasler, Mathieu Vinken, Ciro Tetta, Vera Rogiers, Madlen Matz-Soja, Jian Dong

Publikováno v: ARCHIVES OF TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Archives of toxicology, 2013, Vol.87(8), pp.1315-1530 [Peer Reviewed Journal]
Archives of Toxicology
Archives of Toxicology, Springer Verlag, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Vrije Universiteit Brussel
Archives of Toxicology Vol. 87 Issue 8: pp. 1315-1530
Archives of Toxicology, 2013, 87 (8), pp.1315-530. ⟨10.1007/s00204-013-1078-5⟩
Archives of Toxicology; Vol 87
RODERIC. Repositorio Institucional de la Universitat de Valéncia
Archives of Toxicology; 87(8), pp 1315-1530 (2013)

This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules, the liver consists of approximately 80 % hepatocyte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfbe0eba17d5b39307562eee7f07503
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2598

Lentiviral transduction to drive a liver-derived rat epithelial cell line from biliary origin towards hepatocyte-like cells

Autor: Jennifer Bolleyn, Nisha Nair Shivsankaran Nair, Joery De Kock, Marinee Chuah, Thierry Vandendriessche, Vera Rogiers, Tamara Vanhaecke

Publikováno v: Vrije Universiteit Brussel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8cd31e9c61fc85c632bb6376924f38d3
https://researchportal.vub.be/en/publications/01d2e0df-ceaa-40a7-9e9c-a3623fe3b389