Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jennifer Baysarowich"'
Autor:
Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2611-2618 (2010)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans. PCSK9 has also been shown to regulate the levels of additional membrane-bound proteins in vit
Externí odkaz:
https://doaj.org/article/4c28810f0e7f4bedb9bdad0182e74028
Autor:
Aiwu Zhang, Ronald E. Painter, Stephen F. Previs, Shuo Quan, Heather Zhou, Adam B. Weinglass, Anka G. Ehrhardt, Daphne Szeto, Michael Kavana, Sheng-Ping Wang, Dan Xie, Marina Ichetovkin, Brian K. Hubbard, Larissa Wilsie, Karen O. Akinsanya, Thomas P. Roddy, Oksana C Palyha, Jing Xiao, Mark Rosenbach, Alison M. Strack, Donald Chu, Weihua Ni, Douglas Wisniewski, Douglas G. Johns, Jim Milligan, Paul A. Fischer, Sookhee Ha, Xi Ai, George H. Addona, Thomas F. Vogt, Gail Forrest, Jennifer Baysarowich
Publikováno v:
Biochemistry & Molecular Biology Journal.
Human genetics and pharmacologic clinical intervention demonstrate the key role of PCSK9 in cholesterol regulation. To understand the role of the C-terminal domain of PCSK9, two human mutations in this region (S462P and A522T PCSK9) have been profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80bb26633f7235181b008b1018ab1fa7
https://doi.org/10.21767/2471-8084.100026
https://doi.org/10.21767/2471-8084.100026
Autor:
Marco Mattu, Carl P. Sparrow, Matthew J. Bottomley, Joseph C. Santoro, Lionello Ruggeri, Fabio Talamo, Paola Lo Surdo, Jennifer Baysarowich, Richard T. Cummings, Rose M. Cubbon, Raffaele De Francesco, Laura Orsatti, Ayesha Sitlani, Alessandra Calzetta, Andrea Carfi, A. Noto, Timothy S. Fisher, Agostino Cirillo
Publikováno v:
Journal of Biological Chemistry. 284:1313-1323
PCSK9 regulates low density lipoprotein receptor (LDLR) levels and consequently is a target for the prevention of atherosclerosis and coronary heart disease. Here we studied the interaction, of LDLR EGF(A/AB) repeats with PCSK9. We show that PCSK9 bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79deb7f15c827e7acb5cff540bbd397
https://doi.org/10.1074/jbc.m808363200
https://doi.org/10.1074/jbc.m808363200
Autor:
Kun Zhang, Linda Ejim, Donald W. Hughes, Gerard D. Wright, Emma Griffiths, Jennifer Baysarowich, Murray S. Junop, Kalinka Koteva
Publikováno v:
Proceedings of the National Academy of Sciences. 105:4886-4891
The rifamycin antibiotic rifampin is important for the treatment of tuberculosis and infections caused by multidrug-resistant Staphylococcus aureus . Recent iterations of the rifampin core structure have resulted in new drugs and drug candidates for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b98cd8f729de21987c8d708026277f
https://doi.org/10.1073/pnas.0711939105
https://doi.org/10.1073/pnas.0711939105