Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jennifer Bardenhagen"'
Autor:
Christopher L. Carroll, Jan Reiling, Jeffrey Kovacs, Michael Bradley, Meng He, Nadima Uprety, Michael Peoples, Fredierick Robinson, Alessandro Carugo, Michael Conner, Christian Rodriguez, Jennifer Bardenhagen, Vijayan Ramaswamy, Paul Leonard, Zhijun Kang, Catalina Suarez, Teresa Perry, Jing Han, Sonal Fnu, Nakia D. Spencer, Guang Gao, Angela Harris, Alan Xu, Jennifer Linares, Thomas M. Quill, Phuong Nguyen, Qi Wu, Stephanie T. Schmidt, Sahil Seth, Christopher A. Bristow, Norma Rogers, Simon S. Yu, Hannah E. Shepard, Robert A. Mullinax, Sabina A. Lorca, Kang Le, Reagan Lucas, Sweta Mahaeshwari, Sarah Joseph, Ningping Feng, Yongying Jiang, Joe Marszalek, Michael Soth, Jason Cross, Mary Geck Do, M. Emilia Di Francesco, Timothy P. Heffernan, Philip Jones
Publikováno v:
Leading Edge of Cancer Research Symposium: Poster Session.
Autor:
Jennifer Bardenhagen, Mary K. Geck Do, Ernesto Guccione, Stella R. Hartono, Jason B. Fleming, Timothy P. Heffernan, Meredith A. Miller, Alessandro Carugo, Christopher A. Bristow, Virginia Giuliani, Joseph R. Marszalek, M. Emilia Di Francesco, Hideo Tomihara, Michael Peoples, Giannicola Genovese, Christopher P. Vellano, Timothy A. Yap, Erika Suzuki, Lionel A. Sanz, Anirban Maitra, Angela K. Deem, Ningping Feng, Haoqiang Ying, Jeffrey J. Kovacs, Giulio Draetta, Andrea Viale, Kim Anh Do, Frédéric Chédin, Michael P. Kim, Caleb A. Class, Guang Gao, Philip Jones, Chiu Yi Liu, Qing E. Chang, Johnathon L. Rose, Joseph R. Daniele, Bhavatarini Vangamudi
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across a panel of patient-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea6291739dfb52921c1dcc59bb9fda1
https://escholarship.org/uc/item/2z71j3wn
https://escholarship.org/uc/item/2z71j3wn
Autor:
Qingyun Liu, Sabrina Jeter-Jones, Dawn Bright, Sofia Movérare-Skrtic, Peter Vogel, Jeff Liu, David Potter, Arthur T. Sands, Faika Mseeh, Petra Henning, Ulf H. Lerner, Robert Brommage, David R. Powell, Karin H Nilsson, James E. Tarver, Claes Ohlsson, Andrea Y. Thompson, Gwenn M. Hansen, Jennifer Bardenhagen, Brian Zambrowicz, Melanie K. Shadoan, Jie Cui, Deon Doree
Publikováno v:
Bone Research, Vol 7, Iss 1, Pp 1-12 (2019)
Bone Research
Bone Research
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-v
Autor:
Philip Jones, Timothy P. Heffernan, Natalya Nazarenko, Carlo Toniatti, Giulio Draetta, Anne Yau, Quanyun Xu, Jay Theroff, Nakia D. Spencer, Hannah Shepard, Norma Rogers, Jihai Pang, Wylie S. Palmer, Pietro Morlacchi, Meredith Miller, Timothy McAfoos, Zhen Liu, Zhijun Kang, Troy Johnson, Yongying Jiang, Sha Huang, Virginia Giuliani, Angela Harris, Mary Geck Do, Matthew M . Hamilton, Maria E. Di Francesco, Chris Carroll, Barbara Czako, Christopher Bristow, Jennifer Bardenhagen, Jason P. Burke, Jeffrey J. Kovacs, Gang Liu, Kang Le, Dr. Michael Soth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd6e4734b698474034c7af62ef1da54
https://doi.org/10.1021/scimeetings.0c03462
https://doi.org/10.1021/scimeetings.0c03462
Autor:
Jennifer Bardenhagen, Mary Geck Do, Virginie Buggia-Prevot, Morgan McReynolds, Richard Thomas Lewis, Paul Acton, William J. Ray, Sunil Goodwani, Yaima Luzardo Lightfoot, Philip W. Jones, Janelle N. Fawver-Kahle, Celia G. Fernandez, Cheng Hui Hu, Mary E. Hamby
Publikováno v:
Alzheimer's & Dementia. 15
Autor:
Florian L. Muller, Stefan O. Ciurea, Christopher Carroll, Lina Han, Sergej Konoplev, Timothy P. Heffernan, M. Emilia Di Francesco, Yuting Sun, Polina Matre, Quanyun Xu, Tin Oo Khor, Michael Peoples, John de Groot, Melinda Smith, Sha Huang, Verlene Henry, John M. Asara, Zhijun Kang, Edward F. Chang, Carlo Toniatti, Angela K. Deem, Riccardo Serreli, Yoko Tabe, Virginia Giuliani, Yongying Jiang, Timothy Lofton, Ronald A. DePinho, Helen Ma, Naval Daver, Jennifer Greer, Jennifer R. Molina, Madhavi Bandi, Cross Jason, Pietro Morlacchi, Jing Han, Thomas Shi, Guang Gao, Barbara Czako, Gang Liu, Marina Konopleva, Christopher A. Bristow, Jeffrey J. Ackroyd, Philip Jones, Jay Theroff, Marina Protopopova, Ningping Feng, Alessia Petrocchi, Mikhila Mahendra, Stefano Tiziani, Sonal Gera, Jennifer Bardenhagen, Yu Hsi Lin, Robert A. Mullinax, Qi Zhang, Joseph R. Marszalek, Mary Geck Do, Judy Hirst, Timothy McAfoos, Ahmed Noor A. Agip, Gheath Alatrash, Alessia Lodi, Caroline C. Carrillo, Jaime Rodriguez-Canale, Jian Wen Dong, Giulio Draetta
Publikováno v:
Nature medicine. 24(7)
Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosph
Autor:
Paul G. Leonard, Richard T. Lewis, Mario Cardozo, Naphtali J. Reyna, Carlo Toniatti, Philip Jones, Alessia Petrocchi, Elisabetta Leo, Faika Mseeh, Matthew M. Hamilton, Xi Shi, Connor A. Parker, Giulio Draetta, Sha Huang, Jennifer Bardenhagen, Yongying Jiang, Cross Jason, Joseph R. Marszalek
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
Structure based design of a novel class of aminopyrimidine MTH1 (MutT homolog 1) inhibitors is described. Optimization led to identification of IACS-4759 (compound 5), a sub-nanomolar inhibitor of MTH1 with excellent cell permeability and good metabo
Autor:
Yanai Zhan, Shiming Jiang, Jannik N. Andersen, Elisabetta Leo, Shuping Zhao, Hannah E. Shepard, Giulio Draetta, Joseph R. Marszalek, Wylie S. Palmer, Timothy P. Heffernan, Michelle Craig Barton, Trang N. Tieu, Philip Jones, Carlo Toniatti, Mary K. Geck Do, Jessica K. Tyler, Jennifer Bardenhagen, Xi Shi, Maria Kost-Alimova, Bhavatarini Vangamudi, Srikanth Appikonda
Publikováno v:
Epigenetics & Chromatin
Background Proteins that ‘read’ the histone code are central elements in epigenetic control and bromodomains, which bind acetyl-lysine motifs, are increasingly recognized as potential mediators of disease states. Notably, the first BET bromodomai
Autor:
Trang N. Tieu, Carlo Toniatti, Jennifer Bardenhagen, Hannah E. Shepard, Alessia Petrocchi, Yanai Zhan, Xi Shi, Anne Yau, Naphtali Reyna, G. Poncet-Montange, Jannik N. Andersen, Elisabetta Leo, Michelle Craig Barton, Govindan Subramanian, Giulio Draetta, Wylie S. Palmer, Shuping Zhao, Philip Jones, Jay Theroff, Mary Geck Do, Maria Kost-Alimova, Gang Liu
Publikováno v:
Palmer, W S; Poncet-Montange, G; Liu, G; Petrocchi, A; Reyna, N; Subramanian, G; et al.(2015). Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. UC Office of the President: Multicampus Research Programs and Initiatives (MRPI); a funding opportunity through UC Research Initiatives (UCRI). Retrieved from: http://www.escholarship.org/uc/item/2997633w
The bromodomain containing proteins TRIM24 (tripartite motif containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are involved in the epigenetic regulation of gene expression and have been implicated in human cancer. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d2274e44993fac4ed4392dfab37921
http://www.escholarship.org/uc/item/2997633w
http://www.escholarship.org/uc/item/2997633w
Autor:
Gilbert R. Lee, Mario Cardozo, Xi Shi, Jennifer Bardenhagen, Philip Jones, Alessia Petrocchi, Paul G. Leonard, Wylie S. Palmer, Yanai Zhan, John E. Ladbury, G. Poncet-Montange, Mary K. Geck Do, Jannik N. Andersen, Elisabetta Leo
Publikováno v:
The Biochemical journal. 466(2)
Preventing histone recognition by bromodomains emerges as an attractive therapeutic approach in cancer. Overexpression of ATAD2 (ATPase family AAA domain-containing 2 isoform A) in cancer cells is associated with poor prognosis making the bromodomain