Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jennifer B. Kwon"'
Autor:
Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Publikováno v:
APL Bioengineering, Vol 7, Iss 4, Pp 046103-046103-15 (2023)
Atherosclerosis is a primary precursor of cardiovascular disease (CVD), the leading cause of death worldwide. While proprotein convertase subtilisin/kexin 9 (PCSK9) contributes to CVD by degrading low-density lipoprotein receptors (LDLR) and altering
Externí odkaz:
https://doaj.org/article/f6d0b5cc6b244d04bac23d3123f01c78
Autor:
Jennifer B. Kwon, Adarsh R. Ettyreddy, Ashish Vankara, Joel D. Bohning, Garth Devlin, Stephen D. Hauschka, Aravind Asokan, Charles A. Gersbach
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 320-329 (2020)
Delivery of therapeutic transgenes with adeno-associated viral (AAV) vectors for treatment of myopathies has yielded encouraging results in animal models and early clinical studies. Although certain AAV serotypes efficiently target muscle fibers, tra
Externí odkaz:
https://doaj.org/article/027bf4f182644f8e99d5b59e596aa1d1
Autor:
Pratiksha I. Thakore, Jennifer B. Kwon, Christopher E. Nelson, Douglas C. Rouse, Matthew P. Gemberling, Matthew L. Oliver, Charles A. Gersbach
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Repression of gene transcription using CRISPR-Cas9 has been achieved in vitro but not for delivery into adult animal models. Here, the authors use AAV8 to deliver the transcriptional repressor dSaCas9KRAB to the cholesterol regulator Pcsk9, and show
Externí odkaz:
https://doaj.org/article/46f1559feeb54a51902bab3a11b455bc
Publikováno v:
Stem Cell Reports
Summary Engineered CRISPR/Cas9-based transcriptional activators can potently and specifically activate endogenous fate-determining genes to direct differentiation of pluripotent stem cells. Here, we demonstrate that endogenous activation of the PAX7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017ebf67b3e960c0358a3ee3eeac9093
https://doi.org/10.1016/j.stemcr.2020.03.026
https://doi.org/10.1016/j.stemcr.2020.03.026
Autor:
Moumita Ghosh, Lori D Dwyer-Nield, Jennifer B Kwon, Lea Barthel, William J Janssen, Daniel T Merrick, Robert L Keith
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0122823 (2015)
Squamous cell lung cancer (SCC) is the second leading cause of lung cancer death in the US and has a 5-year survival rate of only 16%. Histological changes in the bronchial epithelium termed dysplasia are precursors to invasive SCC. However, the cell
Externí odkaz:
https://doaj.org/article/3ef37358c39c437190bd187583899505
Autor:
Vidit Bhandarkar, Jennifer B. Kwon, Eric A. Josephs, D. Dewran Kocak, Shaunak S. Adkar, Charles A. Gersbach
Publikováno v:
Nature biotechnology
CRISPR (clustered regularly interspaced short palindromic repeat) systems have been broadly adopted for basic science, biotechnology, and gene and cell therapy. In some cases, these bacterial nucleases have demonstrated off-target activity. This crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd96facacaf79e28df0935d2badb8078
https://doi.org/10.1038/s41587-019-0095-1
https://doi.org/10.1038/s41587-019-0095-1
Autor:
Daniel T. Merrick, Jennifer B. Kwon, York E. Miller, Aik-Choon Tan, Keegan A. Kincaid, Robert L. Keith, Jihye Kim, Hyunmin Kim, Alyx Gray, Moumita Ghosh, Dexiang Gao
Publikováno v:
SSRN Electronic Journal.
Squamous cell lung cancer arises from premalignant dysplasias characterized by squamous replacement of the normal mucociliary airway epithelium. Individuals with persistent, compared to regressive, dysplasias are at increased risk for lung cancer. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748e09cc1cec30a73433bfb04b4a7d78
https://doi.org/10.2139/ssrn.3708515
https://doi.org/10.2139/ssrn.3708515
Autor:
Moumita Ghosh, Daniel T. Merrick, Ichiro Nakachi, Robert L. Keith, Jennifer B. Kwon, Anna E. Barón, York E. Miller, Alexandra E. Brantley, R. William Vandivier, Wilbur A. Franklin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 197:885-896
Rationale: Up to 40% of smokers develop chronic obstructive pulmonary disease (COPD) over a period that spans decades. Despite the importance of COPD, much remains to be learned about susceptibility and pathogenesis, especially during early, prediagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f46e71c6072e9a2cf0f75adc0dca4ad
https://doi.org/10.1164/rccm.201704-0667oc
https://doi.org/10.1164/rccm.201704-0667oc
Autor:
Charles A. Gersbach, Jennifer B. Kwon
Publikováno v:
Nature Biotechnology. 37:1004-1006
CRISPR–Cas-associated transposases enable targeted integration of new sequences into genomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f040f0b9707e4ab464d8306938ad2e31
https://doi.org/10.1038/s41587-019-0210-3
https://doi.org/10.1038/s41587-019-0210-3
Autor:
Jennifer B, Kwon, Charles A, Gersbach
Publikováno v:
Nature biotechnology. 37(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d68f72a0d04198a54e65090c85416cf
https://pubmed.ncbi.nlm.nih.gov/31371821
https://pubmed.ncbi.nlm.nih.gov/31371821