Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jennifer B. Jacob"'
Autor:
Jennifer B. Jacob, Kuang-Chung Wei, Gerold Bepler, Joyce D. Reyes, Andi Cani, Lisa Polin, Kathryn White, Seongho Kim, Nerissa Viola, Julie McGrath, Anthony Guastella, CongCong Yin, Qing-Shen Mi, Benjamin L. Kidder, Kay-Uwe Wagner, Stuart Ratner, Victoria Phillips, Joanne Xiu, Prahlad Parajuli, Wei-Zen Wei
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106320- (2023)
Summary: HER2-targeted therapy has improved breast cancer survival, but treatment resistance and disease prevention remain major challenges. Genes that enable HER2/Neu oncogenesis are the next intervention targets. A bioinformatics discovery platform
Externí odkaz:
https://doaj.org/article/ef28e19612ea43f89c00bb93371e0760
Autor:
Wei-Zen Wei, Ye-Shih Ho, Chella S. David, Daniel P. Snower, Chady Meroueh, Yi-chi M. Kong, Jennifer B. Jacob
Supplementary Figures 1-3 from Control of Her-2 Tumor Immunity and Thyroid Autoimmunity by MHC and Regulatory T Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58400cae00cb25ae7bbf8dc91fb633f7
https://doi.org/10.1158/0008-5472.22368311.v1
https://doi.org/10.1158/0008-5472.22368311.v1
Autor:
Wei-Zen Wei, Ye-Shih Ho, Chella S. David, Daniel P. Snower, Chady Meroueh, Yi-chi M. Kong, Jennifer B. Jacob
Immune reactivity to self-antigens in both cancer and autoimmune diseases can be enhanced by systemic immune modulation, posing a challenge in cancer immunotherapy. To distinguish the genetic and immune regulation of tumor immunity versus autoimmunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d27fd14cabd7c8ae6f2de0aaf3ad9d
https://doi.org/10.1158/0008-5472.c.6495902
https://doi.org/10.1158/0008-5472.c.6495902
Autor:
Wei-Zen Wei, Augusto Amici, Amy Weise, Joyce D. Reyes, Marie P. Piechocki, Richard F. Jones, Olga Radkevich-Brown, Elena Quaglino, Jennifer B. Jacob
Supplementary Figures 1-2 from Combining Human and Rat Sequences in Her-2 DNA Vaccines Blunts Immune Tolerance and Drives Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0143178b025588468d0f870cddf7a54c
https://doi.org/10.1158/0008-5472.22383269.v1
https://doi.org/10.1158/0008-5472.22383269.v1
Autor:
Wei-Zen Wei, Augusto Amici, Amy Weise, Joyce D. Reyes, Marie P. Piechocki, Richard F. Jones, Olga Radkevich-Brown, Elena Quaglino, Jennifer B. Jacob
Immune tolerance to tumor-associated self-antigens poses a major challenge in the ability to mount an effective cancer vaccine response. To overcome immune tolerance to HER-2, we formulated DNA vaccines that express both human HER-2 and heterologous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1b868fdfd6a261068c380de529152dd
https://doi.org/10.1158/0008-5472.c.6500483
https://doi.org/10.1158/0008-5472.c.6500483
Autor:
Yi-chi M. Kong, Alvaro A. Giraldo, Ghazwan Alsharabi, K. David Shim, Jeffrey C. Flynn, John F. Zielinski, Jennifer B. Jacob, Wei-Zen Wei
When CD4+CD25+ regulatory T cells are depleted or inactivated for the purpose of enhancing antitumor immunity, the risk of autoimmune disease may be significantly elevated because these regulatory T cells control both antitumor immunity and autoimmun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d1a3120f82aae5bcf4be5984ea134f
https://doi.org/10.1158/0008-5472.c.6493739
https://doi.org/10.1158/0008-5472.c.6493739
Autor:
Yi-chi M. Kong, Alvaro A. Giraldo, Ghazwan Alsharabi, K. David Shim, Jeffrey C. Flynn, John F. Zielinski, Jennifer B. Jacob, Wei-Zen Wei
Depletion of Treg cells by anti-CD25 mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dbfd3129a4366e80b8769b32f59085
https://doi.org/10.1158/0008-5472.22363505.v1
https://doi.org/10.1158/0008-5472.22363505.v1
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 91
Tumor cells predominantly express self-antigens and overcoming self-tolerance is the primary challenge to effective immunotherapy. Tumors also express ligands for co-inhibitory molecules on immune cells, in order to suppress anti-tumor immunity. Over
Autor:
Shari Pilon-Thomas, Joyce D. Reyes, Jay A. Berzofsky, Jennifer B. Jacob, Gregory Dyson, Hoyoung Maeng, Kuang Chung Wei, Stuart Ratner, Jeffrey A. Frelinger, Heather M. Gibson, Wei Zen Wei
Publikováno v:
J Immunol
The genetic basis and mechanisms of disparate antitumor immune response was investigated in Diversity Outbred (DO) F1 mice that express human HER2. DO mouse stock samples nearly the entire genetic repertoire of the species. We crossed DO mice with sy
Autor:
Cong-Cong Yin, Elizabeth A. Rondini, K Wagner, Joyce D. Reyes, James G. Granneman, Prahlad Parajuli, Jennifer B. Jacob, Wei-Zen Wei, Kuang Wei, Qing-Sheng Mi
Publikováno v:
Cancer Research. 81:2920-2920
Although humans are heterogeneous, evaluation of tumorigenesis and immunotherapy has relied on the use of inbred mouse strains, which may lead to biased results. In order to investigate the effect(s) of genetic background on tumor incidence and immun