Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jennifer B. Delproposto"'
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Despite studies implicating adipose tissue T cells (ATT) in the initiation and persistence of adipose tissue inflammation, fundamental gaps in knowledge regarding ATT function impedes progress toward understanding how obesity influences adaptive immu
Externí odkaz:
https://doaj.org/article/ae48ad9d9bcd41b186a6308361fed8f0
Autor:
Devika P. Bagchi, Akira Nishii, Ziru Li, Jennifer B. DelProposto, Callie A. Corsa, Hiroyuki Mori, Julie Hardij, Brian S. Learman, Carey N. Lumeng, Ormond A. MacDougald
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101078- (2020)
Objective: Canonical Wnt/β-catenin signaling is a well-studied endogenous regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and inhibiting adipogenesis. However, emerging genetic evidence in humans links a number of Wnt
Externí odkaz:
https://doaj.org/article/8ef771209b294ee6b66866f46596ea82
Autor:
Clarissa Strieder-Barboza, Carmen G. Flesher, Lynn M. Geletka, Jennifer B. Delproposto, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P. Ehlers, Robert W. O’Rourke, Carey N. Lumeng
Single-cell and single-nuclei RNA sequencing data (scRNAseq and snRNAseq, respectively) have revealed substantial heterogeneity in the AT (AT) cellular landscape in rodents and humans depending on depot and disease status. We used snRNAseq to charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8586fdade3109a792888813eaca8cabb
https://doi.org/10.1101/2022.06.29.496888
https://doi.org/10.1101/2022.06.29.496888
Autor:
Carey N. Lumeng, Nicki A. Baker, Christopher K. Neeley, Richard L. Youngblood, Carmen G. Flesher, Jennifer B. DelProposto, Lonnie D. Shea, Robert W. O'Rourke, Fanghua Li
Publikováno v:
Biotechnol Bioeng
BACKGROUND: Dysfunctional adipose tissue plays a central role in the pathogenesis of obesity-related metabolic disease, including type 2 diabetes. Targeting adipose tissue using biopolymer implants is a novel therapeutic approach for metabolic diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79912ff4817889c92f8a886e09b23877
https://doi.org/10.1002/bit.27523
https://doi.org/10.1002/bit.27523
Autor:
Carey N. Lumeng, Callie A.S. Corsa, Devika P. Bagchi, Akira Nishii, Ziru Li, Hiroyuki Mori, Julie Hardij, Jennifer B. DelProposto, Ormond A. MacDougald, Brian S. Learman
Publikováno v:
Molecular Metabolism, Vol 42, Iss, Pp 101078-(2020)
Molecular Metabolism
Molecular Metabolism
Objective Canonical Wnt/β-catenin signaling is a well-studied endogenous regulator of mesenchymal cell fate determination, promoting osteoblastogenesis and inhibiting adipogenesis. However, emerging genetic evidence in humans links a number of Wnt p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5de944410fe8fe40526e237baff9eb
http://www.sciencedirect.com/science/article/pii/S2212877820301526
http://www.sciencedirect.com/science/article/pii/S2212877820301526
Autor:
Cameron Griffin, Brian F. Zamarron, Gabriel Martinez-Santibanez, Kanakadurga Singer, Jennifer B. DelProposto, Robert W. O’ Rourke, Carey N. Lumeng, Lindsey A. Muir, Hannah R. Lucas, Lynn M. Geletka, Samadhi Kiridena
Publikováno v:
Journal of Leukocyte Biology. 103:615-628
Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c71d61d00bbe5e165ba8a588426df2
https://doi.org/10.1002/jlb.3hi1017-422r
https://doi.org/10.1002/jlb.3hi1017-422r
Autor:
Cara E. Porsche, Robert W. O'Rourke, Lynn M. Geletka, Carey N. Lumeng, Jennifer B. DelProposto
Publikováno v:
Diabetes. 68
Adipose tissue induced chronic low-grade inflammation is a critical link between obesity and insulin resistance. Despite studies demonstrating the importance of adipose tissue T cells (ATT) in insulin resistance, fundamental gaps in knowledge regardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e4a6143e8a0179448b40fc4133396a
https://doi.org/10.2337/db19-256-lb
https://doi.org/10.2337/db19-256-lb
Autor:
Oliver A. Varban, Carmen G. Flesher, Lynn M. Geletka, Jonathan F. Finks, Alice M. Brosius, Christopher K. Neeley, Joshua S. Chang, Nicki A. Baker, Lindsey A. Muir, Carey N. Lumeng, Jennifer B. DelProposto, Niko Kaciroti, Kevin A. Meyer, Gabriel Martinez-Santibanez, Alexandra R. Washabaugh, Brian F. Zamarron, Robert W. O'Rourke
Publikováno v:
Obesity. 24:597-605
Objective The relationship between adipose tissue fibrosis, adipocyte hypertrophy, and preadipocyte hyperplasia in the context of obesity and the correlation of these tissue-based phenomena with systemic metabolic disease are poorly defined. The goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0caca11755b2347ff3c4335ee0e0a09
https://doi.org/10.1002/oby.21377
https://doi.org/10.1002/oby.21377
Autor:
Lucia Russo, Carmen G. Flesher, Lindsey A. Muir, Nicki A. Baker, Lynn M. Geletka, Jennifer B. DelProposto, Robert W. O'Rourke, Carey N. Lumeng
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 39, Iss, Pp-(2020)
Molecular Metabolism, Vol 39, Iss, Pp-(2020)
Objective Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM). Metabolically activated adipose tissue macrophages (ATMs) undergo qualitative and quantitative cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c438eaea42b22f07ed5f8e16b97608
https://doi.org/10.1016/j.molmet.2020.100983
https://doi.org/10.1016/j.molmet.2020.100983
Publikováno v:
Mol Cell Endocrinol
Adipose tissue derived chronic inflammation is a critical component of obesity induced type II diabetes. Major histocompatibility complex II (MHCII) mediated T cell activation within adipose tissue is one mechanism that contributes to this phenotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c479f9730fd75f5336ca959354f7868f
https://doi.org/10.1016/j.mce.2020.110740
https://doi.org/10.1016/j.mce.2020.110740