Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jennifer B, Stott"'
Autor:
Jennifer B. Stott, Iain A. Greenwood
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The KCNQ family is comprised of five genes and the expression products form voltage-gated potassium channels (Kv7.1–7.5) that have a major impact upon cellular physiology in many cell types. Each functional Kv7 channel forms as a tetramer that ofte
Externí odkaz:
https://doaj.org/article/a07e7dbec107485b9c438c034852acb0
Autor:
Samuel N. Baldwin, Shaun L. Sandow, Gema Mondéjar-Parreño, Jennifer B. Stott, Iain A. Greenwood
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co
Externí odkaz:
https://doaj.org/article/bd48e0b6c26a464081470627100df2e6
Autor:
Iain A. Greenwood, Jennifer B. Stott
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Within the vasculature Kv7 channels are key regulators of basal tone and contribute to a variety of receptor mediated vasorelaxants. The Kv7.4 isoform, abundant within the vasculature, is key to these processes and was recently shown to have an oblig
Externí odkaz:
https://doaj.org/article/a5c223f562154d0e91e1997295c0b8a7
Autor:
Samuel N. Baldwin, Elizabeth A. Forrester, Natalie Z. M. Homer, Ruth Andrew, Vincenzo Barrese, Jennifer B. Stott, Brant E. Isakson, Anthony P. Albert, Iain A. Greenwood
Publikováno v:
Baldwin, S N, Forrester, E A, Homer, N Z M, Andrew, R, Barrese, V, Stott, J B, Isakson, B E, Albert, A P & Greenwood, I A 2022, ' Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1 ', British Journal of Pharmacology . https://doi.org/10.1111/bph.15947
Background and purposeKcnq-encoded KV7 channels (termed KV7.1-5) regulate vascular smooth muscle cell (VSMC) contractility at rest and as downstream targets of receptor mediated responses. However, the current literature focuses predominantly on male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e0759f0cd9255b04c25a24fb956c0a
https://www.pure.ed.ac.uk/ws/files/313271074/British_J_Pharmacology_2022_Baldwin_Marked_oestrous_cycle_dependent_regulation_of_rat_arterial_KV7_4_channels_driven.pdf
https://www.pure.ed.ac.uk/ws/files/313271074/British_J_Pharmacology_2022_Baldwin_Marked_oestrous_cycle_dependent_regulation_of_rat_arterial_KV7_4_channels_driven.pdf
Autor:
Samuel N, Baldwin, Elizabeth A, Forrester, Natalie Z M, Homer, Ruth, Andrew, Vincenzo, Barrese, Jennifer B, Stott, Brant E, Isakson, Anthony P, Albert, Iain A, Greenwood
Publikováno v:
British journal of pharmacologyREFERENCES.
Kcnq-encoded KRT-qPCR, immunocytochemistry, proximity ligation assay and wire myography were performed in renal and mesenteric arteries. Circulating sex hormone concentrations were determined by liquid chromatography-tandem mass spectrometry. Whole-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78a9a1461ae21d9714d146660e14053f
https://pubmed.ncbi.nlm.nih.gov/36085551
https://pubmed.ncbi.nlm.nih.gov/36085551
Autor:
Jennifer B. Stott, Iain A. Greenwood, Gema Mondejar-Parreño, Samuel N. Baldwin, Shaun L. Sandow
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11551913620248303a9c6b0cfa07ec9a
Autor:
Samuel N, Baldwin, Shaun L, Sandow, Gema, Mondéjar-Parreño, Jennifer B, Stott, Iain A, Greenwood
Publikováno v:
Frontiers in Physiology
Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61cb306ff73a5a60d533bc9efc61dfdb
https://pubmed.ncbi.nlm.nih.gov/33364977
https://pubmed.ncbi.nlm.nih.gov/33364977
Autor:
Gema Mondejar-Parreño, Jennifer B. Stott, Shaun L. Sandow, Iain A. Greenwood, Samuel N. Baldwin
Background and purpose KCNQ-encoded KV7 channels are expressed within vascular smooth muscle cells (VSMCs) and are key regulators of vascular reactivity, regulating resting tone and as functional targets of endogenous responses. Endothelial cells (EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b9c4211c9f4495378c1568056a67d9d
https://doi.org/10.22541/au.159060678.84204467
https://doi.org/10.22541/au.159060678.84204467
Autor:
Jennifer B. Stott, Samuel N. Baldwin, Vincenzo Barrese, Iain A. Greenwood, Gema Mondejar-Parreño
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective: The SMIT1 (sodium:myo-inositol transporter 1) regulates myo-inositol movement into cells and responses to hypertonic stimuli. Alteration of myo-inositol levels has been associated
Objective: The SMIT1 (sodium:myo-inositol transporter 1) regulates myo-inositol movement into cells and responses to hypertonic stimuli. Alteration of myo-inositol levels has been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e488f03af47b3d3e05ebffef4079d02
http://hdl.handle.net/11588/832023
http://hdl.handle.net/11588/832023
Publikováno v:
Pflugers Archiv
Kv7.4 channels are key determinants of arterial contractility and cochlear mechanosensation that, like all Kv7 channels, have an obligatory requirement for phosphatidylinositol 4,5-bisphosphate (PIP2). βγ G proteins (Gβγ) have been identified as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3644baa0885b987549901d54f6297a60
http://europepmc.org/articles/PMC5222924
http://europepmc.org/articles/PMC5222924