Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jennifer Aral"'
Autor:
Iain D. G. Campuzano, Emma M. Pelegri-O’Day, Nithya Srinivasan, Jennifer L. Lippens, Pascal Egea, Aiko Umeda, Jennifer Aral, Tianqi Zhang, Arthur Laganowsky, Chawita Netirojjanakul
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(11)
Reversed-phase liquid chromatographic mass spectrometry (rpLC-MS) is a universal, platformed, and essential analytical technique within pharmaceutical and biopharmaceutical research. Typical rpLC method gradient times can range from 5 to 20 min. As m
Autor:
Jennifer Aral, Min Xue, Linda F. Epstein, Keiichi Yoshimatsu, Krista R Fruehauf, Paul E. Rose, Philip Tagari, Jun Fan, Quanhong Zhu, Kenneth J. Shea, Les P. Miranda, John M. Beierle, Adam Weisman
Publikováno v:
Biomacromolecules. 22:1695-1705
We report a metal free synthetic hydrogel copolymer with affinity and selectivity for His6-tagged peptides and proteins. Small libraries of copolymers incorporating charged and hydrophobic functional groups were screened by an iterative process for H
Autor:
Fang-Tsao Hong, Hongyan Li, Derek E. Piper, Leszek Poppe, Philip Wong, Todd Hager, Essa Hu, Jason Long, Jennifer Aral, Narender R. Gavva, Cen Xu, Les P. Miranda, Carl Davis, Dawn Zhu, Sonya G. Lehto, Licheng Shi, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 64:3427-3438
Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of known PAC1R ligand scaffolds, PACAP38 and Maxadilan, wh
Autor:
Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock
Publikováno v:
Drug Metabolism and Disposition. 47:1111-1121
The identification of nonopioid alternatives to treat chronic pain has received a great deal of interest in recent years. Recently, the engineering of a series of Nav1.7 inhibitory peptide-antibody conjugates has been reported, and herein, the precli
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Autor:
Bin Wu, Shanti Amagasu, Jason Long, Justin K. Murray, Kristin L. Andrews, Jennifer Aral, Les P. Miranda, Xuhai Be, Kaustav Biswas, Min-Hwa Jasmine Lin, Dong Liu, Zhulun Wang, Anruo Zou, Bryan D. Moyer, Joseph Ligutti, Xiaoshan Min, Kelvin Sham, Thomas Kornecook, Christopher P Ilch
Publikováno v:
Journal of Medicinal Chemistry. 61:9500-9512
Inhibitors of the voltage-gated sodium channel NaV1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified NaV1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula venom screens. Potency and select
Autor:
Justin K, Murray, Bin, Wu, Christopher M, Tegley, Thomas E, Nixey, James R, Falsey, Brad, Herberich, Li, Yin, Kelvin, Sham, Jason, Long, Jennifer, Aral, Yuan, Cheng, Chawita, Netirojjanakul, Liz, Doherty, Charles, Glaus, Tayo, Ikotun, Hongyan, Li, Linh, Tran, Marcus, Soto, Hossein, Salimi-Moosavi, Joseph, Ligutti, Shanti, Amagasu, Kristin L, Andrews, Xuhai, Be, Min-Hwa Jasmine, Lin, Robert S, Foti, Christopher P, Ilch, Beth, Youngblood, Thomas J, Kornecook, Margaret, Karow, Kenneth W, Walker, Bryan D, Moyer, Kaustav, Biswas, Les P, Miranda
Publikováno v:
ACS chemical biology. 14(4)
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel Na
Autor:
Kevin Gaida, Xuxia Zhang, Robin Elliott, Benxian Liu, Andrea Itano, Cynthia Park, Justin K. Murray, Colin V. Gegg, Jennifer Aral, Les P. Miranda, Joseph G. McGivern, Hongyan Li, Anne Colombero, E. Allen Sickmier, Kevin Salyers, Michael Stenkilsson, Jonathan Werner, Steven Yu, Mark J. Rose, John K. Sullivan, Yi-Xin Qian, Peter Miu, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 58:6784-6802
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of
Autor:
Licheng Shi, Jennifer Aral, Richard S. Rogers, Violeta G. Valladares, Hongyan Li, Marie E. Wright, Kevin Salyers, Eileen Johnson, Jerry Ryan Holder, Les P. Miranda, Kenneth W. Walker, George Doellgast, Colin V. Gegg, Kenneth D. Wild, Brian D. Bennett
Publikováno v:
Journal of Medicinal Chemistry. 51:7889-7897
Calcitonin gene-related peptide (CGRP) is a 37-residue neuropeptide that can be converted to a CGRP(1) receptor antagonist by the truncation of its first seven residues. CGRP(8-37), 1, has a CGRP(1) receptor K(i) = 3.2 nM but is rapidly degraded in h
Autor:
Hongyan Li, Shanaka Stanislaus, Jennifer Aral, Mark Guido, Ankita Patel, Jingwen Zhang, Colin V. Gegg, Stephanie Diamond, Leszek Poppe, Jason Long, Les P. Miranda, Murielle M. Véniant, Mark J. Rose, Mark Ma, Katherine Ann Winters
Publikováno v:
Journal of Medicinal Chemistry. 51:2758-2765
A series of conformationally constrained derivatives of glucagon-like peptide-1 (GLP-1) were designed and evaluated. By use of [Gly (8)]GLP-1(7-37)-NH2 (2) peptide as a starting point, 17 cyclic derivatives possessing i to i + 4, i to i + 5, or i to