Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jennifer Albaneze-Walker"'
Autor:
Jennifer Albaneze-Walker, Gregor Urbanietz, Andras Horvath, Stefano Lancianesi, Alejandro Gimenez Molina, Thomas De Vijlder, Mattijs Baeten, Martine Canters
Publikováno v:
The Journal of organic chemistry. 87(19)
Azido nucleosides couple with phosphoramidites via an initial iminophosphorane, which eliminates acrylonitrile to generate the coupled dimer P(V) product. The vulnerable phosphite triester intermediate is bypassed entirely, making the methodology ver
Autor:
Anny Jutand, Luca Alessandro Perego, Laurence Grimaud, Chanelle Tocqueville, Alexandre Simon, Jennifer Albaneze-Walker, Aida Franco-Espejo, Simon Wagschal
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(28)
Understanding the nature of the intermediate species operating within a palladium catalytic cycle is crucial for developing efficient cross-coupling reactions. Even though the XPhos/Pd(OAc)2 catalytic system has found numerous applications, the natur
Autor:
Derek W. Henderson, Benjamin T. Dorner, Christopher J. Welch, Leonard William, John Y. L. Chung, Jennifer Albaneze-Walker, Frederick W. Hartner, Peter Sajonz, Karla G. Childers
Publikováno v:
Organic Process Research & Development. 12:81-87
A screening approach for identifying adsorbents and conditions for selective removal of colored impurities from solutions of pharmaceutical intermediates is described. In this method, a variety of process adsorbents are evaluated using a combination
Autor:
David L. Hughes, Arash Soheili, Charles Bazaral, Jennifer Albaneze-Walker, Shawn A. Springfield, Peter G. Dormer, Scott S. Ceglia, Jerry A. Murry
Publikováno v:
Tetrahedron. 61:6330-6336
An efficient synthesis of a potent PDE IV inhibitor 1 is described. The synthesis is highlighted by two practical and efficient catalytic reactions: a highly selective catalytic palladium mediated carbonylation of the pyridine side chain and an effic
Autor:
Leonard William, Mirlinda Biba, Derek W. Henderson, Christopher J. Welch, Tiebang Wang, Jennifer Albaneze-Walker, Sandra Spencer, Brian Laing, and Xiaodong Bu, David J. Mathre, Jimmy O. DaSilva
Publikováno v:
Organic Process Research & Development. 9:198-205
A microtube screening approach affords simple and convenient assessment of the selective adsorption of metal impurities by a variety of different process adsorbents. This approach is helpful in identifying rapid solutions to metal impurity problems i
Publikováno v:
Organic Letters. 6:2097-2100
[reaction: see text] Optimized conditions are described that effect the carbonylation of diverse heterocyclic chlorides to yield the desired alkyl esters. In addition, bromoanilines and bromoanisoles, which normally are poor substrates under standard
Publikováno v:
Organic Letters. 5:4191-4194
[reaction: see text]. A mild and general protocol for the copper-free Sonogashira coupling of aryl bromides with acetylenes has been developed. The use of (AllylPdCl)2 and P(t-Bu)3 provides the active Pd(0) catalyst that allows subsequent coupling of
Autor:
James M. McNamara, Melinda D. Baker, Matthew M. Zhao, Jennifer Albaneze-Walker, Peter G. Dormer
Publikováno v:
Tetrahedron Letters. 43:6747-6750
Pyrazinecarbonitriles can be decyanated by hydrogenation with platinum on carbon in the presence of activated carbon under acidic conditions. Pyrazine carbonitrile-N-oxides undergo a stepwise reduction to the deoxy-pyrazinecarbonitriles followed by d
Autor:
Courtney C. Aldrich, Jerome Mammen, Craig A. Merlic, Jennifer Albaneze-Walker, and Alan Saghatelian
Publikováno v:
The Journal of Organic Chemistry. 66:1297-1309
The total syntheses of the potent protein kinase C inhibitors calphostins A, B, C, and D as well as a variety of structural analogues are reported. An aminobenzannulation reaction of an enantiopure chromium Fischer carbene complex is utilized to prep
Publikováno v:
Tetrahedron Letters. 40:4917-4920
Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet-Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.