Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jennifer Adelsperger"'
1
The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFR and FIP1L1-PDGFR in vitro and in vivo
Autor: James D. Griffin, Elizabeth McDowell, Jennifer Adelsperger, Jing Chen, Paul W. Manley, Allison Coburn, Elizabeth H. Stover, Sandra A. Moore, Rachel Okabe, Benjamin H. Lee, Dana E. Cullen, D. Gary Gilliland, Doriano Fabbro, Jan Cools
Publikováno v: Blood. 106:3206-3213
AMN107 is a small molecule tyrosine kinase inhibitor developed, in the first instance, as a potent inhibitor of breakpoint cluster region-abelson (BCR-ABL). We tested its effectiveness against fusion tyrosine kinases TEL-platelet-derived growth facto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f23de8805f0e4455837a0812f10f98
https://doi.org/10.1182/blood-2005-05-1932
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2
FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies
Autor: Nicole Duclos, Jeffery L. Kutok, Constantine S. Mitsiades, Allison Coburn, Jennifer Adelsperger, D. G. Gilliland, Rachel Okabe, Brian J. P. Huntly, James D. Griffin, Ifor R. Williams, Benjamin H. Lee, Sandra A. Moore, Jing Chen, Kenneth C. Anderson, Sarah Cohen, Doriano Fabbro
Publikováno v: Oncogene. 24:8259-8267
Reccurent chromosomal translocation t(4;14) (p16.3;q32.3) occurs in patients with multiple myeloma (MM) and is associated with ectopic overexpression of fibroblast growth factor receptor 3 (FGFR3) that sometimes may contain the activation mutations s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce29b28e6dba9353d6ac4d4b192ca71
https://doi.org/10.1038/sj.onc.1208989
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3
Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
Autor: Jennifer J. Clark, Joseph D. Growney, Jennifer Adelsperger, Doriano Fabbro, D. Gary Gilliland, James D. Griffin, Richard Stone
Publikováno v: Blood. 106:721-724
Constitutively activated forms of the transmembrane receptor tyrosine kinase c-KIT have been associated with systemic mast cell disease, acute myeloid leukemia, and gastrointestinal stromal tumors. Reports of the resistance of the kinase domain mutat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdbcd1c08b912a680a29b604edf6a3e
https://doi.org/10.1182/blood-2004-12-4617
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4
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
Autor: Jonathan A. Fletcher, Sheng Xiao, Allison Coburn, Rachel Okabe, James D. Griffin, Ilene Galinsky, Ifor R. Williams, Benjamin H. Lee, Brian J. P. Huntly, Daniel J. DeAngelo, Richard Stone, Lolita Banerji, Jennifer Adelsperger, Pamela S. Cohen, Jeffery L. Kutok, Nicole Duclos, Martha Wadleigh, Jing Chen, Doriano Fabbro, D. Gary Gilliland, Sarah L. Cohen, Thomas F. Meyer, Johannes Roesel
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 101(40)
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute myeloid leukemia and/or lymphoma. The syndrome associated with t(8;13)(p11;q12) results in expression of the ZNF198-fibrob
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6b7f49ad31cea313869c8aee0c7f13
https://pubmed.ncbi.nlm.nih.gov/15448205
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6
Inhibition of the NPM-ALK Fusion Tyrosine Kinase in Hematopoietic Neoplasia by the Small Molecule Tyrosine Kinase Antagonist TAE684
Autor: Naznin Haq, Nicole Duclos, Johannes Roesel, David W. Sternberg, Elizabeth McDowell, Patricia Imbach, Benjamin H. Lee, Arghya Ray, James D. Griffin, Jennifer Adelsperger, Markus Warmuth, Osamu Ohmori, Doriano Fabbro, Toshiyuki Honda
Publikováno v: Blood. 108:828-828
Anaplastic large cell lymphoma (ALCL) constitutes approximately 10–30 percent of childhood lymphomas and 3 percent of non-Hodgkin lymphomas in adults. Approximately 50–60 percent of ALCL patients express the ALK tyrosine kinase fused to a variety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42194e9e52ef6f79c6a1a67943aed1ba
https://doi.org/10.1182/blood.v108.11.828.828
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7
Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype
Autor: Joseph D. Growney, Hirokazu Shigematsu, Zhe Li, Benjamin H. Lee, Jennifer Adelsperger, Rebecca Rowan, David P. Curley, Koichi Akashi, Ifor R. Williams, Nancy A. Speck, D. Gary Gilliland
Publikováno v: Blood. 104:227-227
Homozygous loss of function of Runx1 during murine development results in an embryonic lethal phenotype characterized by a complete lack of definitive hematopoiesis. In light of recent reports of disparate requirements for hematopoietic transcription
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c88fd42d03e0560691536db4e5d5563c
https://doi.org/10.1182/blood.v104.11.227.227
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