Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients

Autor: Elena Rodríguez-Sánchez, José Alberto Navarro-García, Jennifer Aceves-Ripoll, Gloria Álvarez-Llamas, Julián Segura, María G. Barderas, Luis Miguel Ruilope, Gema Ruiz-Hurtado

Publikováno v: Nefrología (English Edition), Vol 39, Iss 2, Pp 184-191 (2019)

Background and objective: Matrix metalloproteinases (MMPs) are involved in deleterious tissue remodelling associated with target organ damage in renal disease. The aim of this study was to study the association between renal dysfunction and activity

Externí odkaz: https://doaj.org/article/1cfec462e2cd492089e891ecbcae9e91

Oxidized Low-Density Lipoprotein Associates with Ventricular Stress in Young Adults and Triggers Intracellular Ca2+ Alterations in Adult Ventricular Cardiomyocytes

Autor: Elena Rodríguez-Sánchez, José Alberto Navarro-García, Laura González-Lafuente, Jennifer Aceves-Ripoll, Sara Vázquez-Sánchez, Jonay Poveda, Elisa Mercado-García, Nerea Corbacho-Alonso, Eva Calvo-Bonacho, María Fernández-Velasco, Gloria Álvarez-Llamas, María G. Barderas, Luis M. Ruilope, Gema Ruiz-Hurtado

Publikováno v: Antioxidants, Vol 9, Iss 12, p 1213 (2020)

Oxidized low-density lipoprotein (oxLDL) is associated with cardiac damage and causes injury to multiple cell types. We aimed to investigate the role of oxLDL in ventricular stress. We first examined the association between circulating oxLDL and N-te

Externí odkaz: https://doaj.org/article/c53d8fecb98c4102bb54fb12366e9654

Enhanced Klotho availability protects against cardiac dysfunction induced by uraemic cardiomyopathy by regulating Ca 2+ handling

Autor: Tatiana Romero-Garcia, José Alberto Navarro-García, Carlos Zaragoza, María Fernández-Velasco, Makoto Kuro-o, Gema Ruiz-Hurtado, Elena Rodríguez-Sánchez, Angélica Rueda, Jennifer Aceves-Ripoll, Laura González-Lafuente, Luis M. Ruilope

Publikováno v: DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria
instname
DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria
Universidad Francisco de Vitoria

Background and Purpose Klotho is a membrane‐bound or soluble protein, originally identified as an age‐suppressing factor and regulator of mineral metabolism. Klotho deficiency is associated with the development of renal disease, but its role in c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3349c34451337f6c74bbe4ef2acd638
https://doi.org/10.1111/bph.15235

Interplay between mineral bone disorder and cardiac damage in acute kidney injury: from Ca 2+ mishandling and preventive role of Klotho in mice to its potential mortality prediction in human

Autor: LAURA GONZÁLEZ-LAFUENTE, JOSÉ ALBERTO NAVARRO-GARCÍA, ELENA RODRÍGUEZ-SÁNCHEZ, JENNIFER ACEVES-RIPOLL, JONAY POVEDA, SARA VÁZQUEZ-SÁNCHEZ, ELISA MERCADO-GARCÍA, MARÍA FERNÁNDEZ-VELASCO, MAKOTO KURO-O, FERNANDO LIAÑO, LUIS M. RUILOPE, GEMA RUIZ-HURTADO

Biomarkers of mineral bone disorders (MBD) including phosphorus, fibroblast growth factor (FGF)-23 and Klotho are strongly altered in patients with acute kidney injury (AKI) who have high cardiac outcomes and mortality rates. However, the crosslink b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7220327c2480e6c9c4542171e71543
https://hdl.handle.net/11268/11150

Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes

Autor: Fernando Arribas, Evangelina Mérida-Herrero, Luis M. Ruilope, Eduardo Hernández, Carmen Delgado, Nieves Gomez-Hurtado, Rafael Salguero, Juan F. Delgado, Héctor Bueno, Gema Ruiz-Hurtado, Jorge Solis, José Alberto Navarro-García, Manuel Praga, Teresa Bada-Bosch, Almudena Val-Blasco, Elena Rodríguez-Sánchez, Jennifer Aceves-Ripoll, María Fernández-Velasco, Makoto Kuro-o

[Background]: Cardiac dysfunction and arrhythmia are common and onerous cardiovascular events in end-stage renal disease (ESRD) patients, especially those on dialysis. Fibroblast growth factor (FGF)-23 is a phosphate-regulating hormone whose levels d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113ecd3b6ee2c78f4fe005650725486b
https://hdl.handle.net/11268/7856