Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jennifer A. Whang"'
Publikováno v:
Cancer Research. 82:5592-5592
KZR-261 is a first-in-class small molecule Sec61 inhibitor currently in a Phase I clinical trial in patients with advanced solid tumors (NCT05047536). We previously reported that KZR-261 and KZR-834, a structural analog, potently blocked the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bfbd92932be7f6dd122ed80e1c90575
https://doi.org/10.1158/1538-7445.am2022-5592
https://doi.org/10.1158/1538-7445.am2022-5592
Autor:
Beatriz Millare, Dustin McMinn, Jennifer A. Whang, Eric Lowe, Meera Rao, Andrea R. Fan, Christopher J. Kirk
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Many tumor cells escape immune cell clearance by overexpressing CD47, a multi-pass transmembrane protein, which binds signal regulatory protein α (SIRPα) on macrophages leading to decreased phagocytic activity. Blockade of CD47/SIRPα in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e74b4faa91a4682ceb69fbaffd2bfd
https://doaj.org/article/084b6f59a49e4906acef1c9da2333497
https://doaj.org/article/084b6f59a49e4906acef1c9da2333497
Autor:
Yu Qian, Jennifer A. Whang, Eric Lowe, Tony Muchamuel, Beatriz Millare, Henry Johnson, Janet L. Anderl, Jinhai Wang, Dustin McMinn, Christopher J. Kirk
Publikováno v:
Cancer Research. 81:323-323
Secreted and transmembrane (TM) proteins play key roles in malignant transformation and tumor growth. During translation, the majority of these proteins require translocation through the Sec61 protein complex into the endoplasmic reticulum (ER) for f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e7dd7fe1d4a2a15f4f9531e6039ef0f
https://doi.org/10.1158/1538-7445.am2021-323
https://doi.org/10.1158/1538-7445.am2021-323
Autor:
Yu Qian, Jennifer A. Whang, Jing Jiang, Brian B. Tuch, Tony Muchamuel, Beatriz Millare, Christopher J. Kirk, Patricia Zuno, R. Andrea Fan, Dustin McMinn, Henry Johnson, Eric Lowe
Publikováno v:
Journal of Clinical Oncology. 38:3582-3582
3582 Background: Secreted and transmembrane proteins play key roles in malignant transformation and growth, including in autocrine growth factor expression, receptor oncogene signaling, and immune system evasion. Biogenesis of these proteins involves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e65da92d224c73a4f87cdf2ca2aa0524
https://doi.org/10.1200/jco.2020.38.15_suppl.3582
https://doi.org/10.1200/jco.2020.38.15_suppl.3582
Autor:
Jinhai Wang, Tony Muchamuel, Andrea R. Fan, Ying Fang, Jennifer A. Whang, Janet L. Anderl, Jack Taunton, Meera Rao, Jing Jiang, Eric Lowe, Phillip P. Sharp, Christopher J. Kirk, Henry Johnson, Dustin McMinn
Publikováno v:
Cancer Research. 79:3860-3860
Secreted and membrane proteins play key roles in malignant transformation and tumor growth, including autocrine growth factor expression, receptor oncogene signal transduction pathways, metastasis, and immune system evasion. The biogenesis of most se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9777a9e4cf64bd6072a117f6598820c
https://doi.org/10.1158/1538-7445.am2019-3860
https://doi.org/10.1158/1538-7445.am2019-3860
Autor:
Janet L. Anderl, Jennifer A. Whang, Eric Lowe, Henry Johnson, Jack Taunton, Jing Jiang, Christopher J. Kirk, Tony Muchamuel, Andrea R. Fan, Dustin McMinn
Publikováno v:
Cancer Research. 79:3087-3087
The majority of secreted and transmembrane (TM) proteins, including growth factors and TM oncogenes, require translocation through Sec61 into the ER for further processing. Sec61, therefore, represents a unique drug discovery opportunity through bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88120a2507fe0871332c41d9f2b6f692
https://doi.org/10.1158/1538-7445.am2019-3087
https://doi.org/10.1158/1538-7445.am2019-3087