Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer A. Trosko"'
Autor:
Susan M. Domchek, Tiziana Usari, Gabriella L. Mariani, Jens Rüter, Jennifer A. Trosko, Prudence Dorazio, Denis Soulieres, Divis Khaira, Elaina M. Gartner, Magi Khalil, Patricia M. LoRusso, Robert H. Vonderheide
Purpose: Tremelimumab is a fully human monoclonal antibody specific for CTL-associated antigen 4 (CTLA4) with single-agent activity in certain tumors but has not been evaluated in patients with breast cancer.Experimental Design: In a phase 1 study, 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8fc5dcbea0fdaffb4d23736443ee07
https://doi.org/10.1158/1078-0432.c.6518074
https://doi.org/10.1158/1078-0432.c.6518074
Autor:
Susan M. Domchek, Tiziana Usari, Gabriella L. Mariani, Jens Rüter, Jennifer A. Trosko, Prudence Dorazio, Denis Soulieres, Divis Khaira, Elaina M. Gartner, Magi Khalil, Patricia M. LoRusso, Robert H. Vonderheide
Supplementary Data from Tremelimumab in Combination with Exemestane in Patients with Advanced Breast Cancer and Treatment-Associated Modulation of Inducible Costimulator Expression on Patient T Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3e12c7e089d4965f17d20ed5ed33d8
https://doi.org/10.1158/1078-0432.22440799.v1
https://doi.org/10.1158/1078-0432.22440799.v1
Autor:
Rosemarie Mick, Naveed Shaik, Omid Hamid, Dongguang Li, Jennifer M. Burg, Jennifer A. Trosko, Robert H. Vonderheide, Anthony W. Tolcher
Publikováno v:
Oncoimmunology
CD40 is a cell-surface molecule that critically regulates immune responses. CP-870,893 is a fully human, CD40-specific agonist monoclonal antibody (mAb) exerting clinical antineoplastic activity. Here, the safety of CP-870,893 combined with carboplat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9753fe58b6e9114a5af041d8caa1100c
http://europepmc.org/articles/PMC3583942
http://europepmc.org/articles/PMC3583942
Autor:
Charles H. Pletcher, Nicole A. Aqui, James L. Riley, Rosemarie Mick, Andrew J. Rech, Sunil Martin, Angela DeMichele, Susan M. Domchek, L. Leinbach, Carol Kaplan Tweed, Jennifer A. Trosko, Robert H. Vonderheide, Adri Recio, Theresa A. Colligon, Daniel J. Powell, Kevin Fox
Publikováno v:
Science Translational Medicine. 4
Regulatory T cells (T(regs)) are key mediators of immune tolerance and feature prominently in cancer. Depletion of CD25(+) FoxP3(+) T(regs) in vivo may promote T cell cancer immunosurveillance, but no strategy to do so in humans while preserving immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f834c42ba8f389a854f2591e2dfa29d5
https://doi.org/10.1126/scitranslmed.3003330
https://doi.org/10.1126/scitranslmed.3003330
Autor:
Jens Rüter, Divis Khaira, Jennifer A. Trosko, Gabriella L. Mariani, Denis Soulières, Susan M. Domchek, Prudence Dorazio, Tiziana Usari, Magi Khalil, Patricia LoRusso, Elaina M. Gartner, Robert H. Vonderheide
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 16(13)
Purpose: Tremelimumab is a fully human monoclonal antibody specific for CTL-associated antigen 4 (CTLA4) with single-agent activity in certain tumors but has not been evaluated in patients with breast cancer. Experimental Design: In a phase 1 study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97d1c15afaaef6bf47804f46d95133f
https://pubmed.ncbi.nlm.nih.gov/20479064
https://pubmed.ncbi.nlm.nih.gov/20479064