Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jennifer A. Tomczak"'
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 7: Reintroduction of TRβ Increased Markers of Thyroid Differentiation. Thyroid differentiation markers were significantly induced in SW-TRβ cells treated with T3 (n=3, * p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d9e4d35328bfacff12923dc0a95094
https://doi.org/10.1158/1541-7786.22527108
https://doi.org/10.1158/1541-7786.22527108
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
The thyroid hormone receptor beta (TRβ), a key regulator of cellular growth and differentiation, is frequently dysregulated in cancers. Diminished expression of TRβ is noted in thyroid, breast, and other solid tumors and is correlated with more agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ae2f1ca6ce598618056d1bb4003f48f
https://doi.org/10.1158/1541-7786.c.6545331.v1
https://doi.org/10.1158/1541-7786.c.6545331.v1
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Pathway Analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db2130f925e942c5c4cf5e60930d06c
https://doi.org/10.1158/1541-7786.22527096.v1
https://doi.org/10.1158/1541-7786.22527096.v1
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 4: TRβ Regulates Expression of lncRNAs in ATC Cells. A) A pairwise comparison between SW-EV-T3 and SW-TRβ-T3 reveals differential expression of both mRNAs and lncRNAs (log2(foldchange)>2 and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4a8c37e0c43904330c20edef026065
https://doi.org/10.1158/1541-7786.22527117.v1
https://doi.org/10.1158/1541-7786.22527117.v1
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 1: TRβ Repressed PI3K Signaling. A) Endogenous expression of TRβ is greater in KTC-2 cells than in SW1736. B-C) ATC cell lines were treated with T3 for up to 8 days to measure cell counts. D) Growth kinetics of KTC-2 cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5dcfc1c72607430cd5cfc6aa07d09d
https://doi.org/10.1158/1541-7786.22527129
https://doi.org/10.1158/1541-7786.22527129
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 6: TRβ Induced a more Differentiated Phenotype. RNA-sequencing data revealed statistically significant increase of the epithelial marker CDH1 and repression of the mesenchymal marker VIM. Although SNAI1 was expressed, no signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f64b1f143351da1ecc531e95d5fe7e
https://doi.org/10.1158/1541-7786.22527111.v1
https://doi.org/10.1158/1541-7786.22527111.v1
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 8: Reintroduction of TRβ Increased Expression of interferon/JAK1/STAT1 Pathway Effectors. A-C) Following 24 hours of treatment with T3 or vehicle, protein levels in SW-EV and SW-TRβ were assessed by western blot. TRβ induced ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0b8de7b90974684f5158e8a33d0406
https://doi.org/10.1158/1541-7786.22527105
https://doi.org/10.1158/1541-7786.22527105
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 2: TRβ Repressed PI3K Signaling. A-I) Expression of cluster 1 differentially expressed genes in the ILK signaling IPA pathway. All genes were repressed by T3 and the level of most of these genes was repressed in the SW-TRβ-T3 co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2007be871ebcad94204af76a836eaa21
https://doi.org/10.1158/1541-7786.22527126.v1
https://doi.org/10.1158/1541-7786.22527126.v1
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 5: TRβ Alters Expression of Key Cell Cycle Regulators. RNA-sequencing data revealed statistically significant increase of the anti-proliferative gene CDKN1A and repression the pro-proliferative gene MYC. n=3, ** p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356b29f0cf07bd5e1df5fc3130d2a3a9
https://doi.org/10.1158/1541-7786.22527114
https://doi.org/10.1158/1541-7786.22527114
Autor:
Frances E. Carr, Seth Frietze, Jennifer A. Tomczak, Lauren Cozzens, Princess D. Rodriguez, Cole D. Davidson, Noelle E. Gillis, Eric L. Bolf
Supplemental Figure 3: RNA-sequencing of the TRβ-Regulated Transcriptome Reveals a Transcription Factor Network. A) Chromatin Enrichment Analysis (ChEA) of differential expression clusters was performed to evaluate which transcription factor network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949d0f4af3e0498a081ee6f29639a5c3
https://doi.org/10.1158/1541-7786.22527123
https://doi.org/10.1158/1541-7786.22527123