Výsledky vyhledávání - "Jennifer A. Stover"

Population pharmacokinetics of CCI-779: Correlations to safety and pharmacogenomic responses in patients with advanced renal cancer

Autor: Cathie Leister, Joseph Boni, Gregor Bender, Fred Immermann, Natalie C. Twine, Virginia Fitzpatrick, Michael E. Burczynski, Jennifer Ann Stover, Andrew J. Dorner

Publikováno v: Clinical Pharmacology & Therapeutics. 77:76-89

Objective Our objective was to estimate the pharmacokinetic parameters of CCI-779 and its metabolite, sirolimus, and evaluate associations of exposure parameters with safety and clinical activity. Exposure parameters were also correlated with pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d363fe933af592035c26ef5b21c7ae2
https://doi.org/10.1016/j.clpt.2004.08.025

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Molecular profile of peripheral blood mononuclear cells from patients with rheumatoid arthritis

Autor: Marc Feldmann, Debra D. Pittman, Jonathan T Beech, Brian M. J. Foxwell, Jennifer A. Stover, Jeffrey L. Feldman, William L. Trepicchio, Christopher J Edwards, Kathleen M. Shields, Glenn Larsen, Fionula M. Brennan

Publikováno v: Molecular medicine (Cambridge, Mass.). 13(1-2)

Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor prognosis are not always reliable. Gene expression in RA may consist of a unique signature. Gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f17579c70bb6edaafc9e92ce7d3a9ce
http://ora.ox.ac.uk/objects/uuid:0ef1435f-ab28-417f-acd7-a24be1a44d91

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Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

Autor: Natalie C, Twine, Jennifer A, Stover, Bonnie, Marshall, Gary, Dukart, Manuel, Hidalgo, Walter, Stadler, Theodore, Logan, Janice, Dutcher, Gary, Hudes, Andrew J, Dorner, Donna K, Slonim, William L, Trepicchio, Michael E, Burczynski

Publikováno v: Cancer research. 63(18)

Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40b846a0e1b0a230c7418567e5b5f6ae
https://pubmed.ncbi.nlm.nih.gov/14522937

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Population pharmacokinetic, pharmacodynamic, and pharmacogenomic analysis of CCI-779 in patients with advanced renal cell cancer

Autor: Andrew J. Dorner, Gregor Bender, Cathie Leister, Fred Immermann, Virginia Fitzpatrick, Joseph Boni, Natalie C. Twine, Michael E. Burczynski, Jennifer Ann Stover

Publikováno v: Clinical Pharmacology & Therapeutics. 75:P41

CCI-779 (CCI) is a novel mTOR kinase inhibitor being developed for treatment of various cancers. In this randomized, double-blind, multicenter trial, 25, 75, or 250 mg IV CCI was given once weekly to 110 patients with renal cancer and was shown to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::114eee257f80a37a3c0dd18defa447d2
https://doi.org/10.1016/j.clpt.2003.11.155

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