Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jennifer A. Shumilla"'
Autor:
John H. Mahoney, Matthew I. Gross, Sharmila Vijay, Linda R. Watkins, Jennifer A. Shumilla, Kirk W. Johnson, Lance Sultzbaugh, Joseph A. Vargas, Tongyao Liu, Laura M. Sanftner, Annemarie Ledeboer, Mark D. Claypool
Publikováno v:
Neuron Glia Biology. 2:279-291
Controlling neuropathic pain is an unmet medical need and we set out to identify new therapeutic candidates. AV411 (ibudilast) is a relatively nonselective phosphodiesterase inhibitor that also suppresses glial-cell activation and can partition into
Publikováno v:
The Journal of Pain. 6:535-549
Ethanol (EtOH) withdrawal increases sensitivity to painful stimuli in adult rats. In this study, withdrawal from a single, acute administration of EtOH dose-dependently produced mechanical allodynia and thermal hyperalgesia in postnatal day 7 (P7) ra
Publikováno v:
Neuroscience Letters. 367:29-33
We have previously reported that withdrawal from acute ethanol (EtOH) exposure lowers mechanical thresholds in post-natal day 7 (P7) and post-natal day 21 (P21) rats. The present study tested the hypothesis that daily administration of 4 g/kg 15% EtO
Publikováno v:
Neuroscience Letters. 366:332-335
We have previously found that in post-natal day 7 rats withdrawal from acute and chronic ethanol (EtOH) exposure lowers mechanical thresholds during withdrawal and exacerbates spontaneous pain responses to an inflammatory injury 4 days post-withdrawa
Autor:
Jennifer Huang, Vashti Lacaille, Jennifer A. Shumilla, David A. Relman, Tara M. C. Hornell, Supraja Narasimhan, Elizabeth D. Mellins
Publikováno v:
Infection and Immunity. 72:1450-1462
Bordetella pertussisis the causative agent of whooping cough, a potentially lethal respiratory disease in children. In immunocompetent individuals,B. pertussisinfection elicits an effective adaptive immune response driven by activated CD4+T cells. Ho
Publikováno v:
Seminars in Pain Medicine. 1:206-219
Acute morphine withdrawal results in enhanced responsiveness to noxious stimulation in adult humans and rodents. This study extends these findings by demonstrating that acute morphine withdrawal produces allodynia in neonatal rats that is dependent o
Publikováno v:
Journal of Biological Chemistry. 274:36207-36212
Chromium(VI) regulation of gene expression has been attributed to the generation of reactive chromium and oxygen species, DNA damage, and alterations in mRNA stability. However, the effects of Cr(VI) on signal transduction leading to gene expression
Publikováno v:
Neuroscience letters. 384(3)
Propentofylline is a phosphodiesterase inhibitor that has been shown to attenuate the onset of morphine tolerance when administered intrathecally to rats. The present studies examined whether systemic administration could be effective in attenuating
Publikováno v:
The journal of pain. 6(8)
Ethanol (EtOH) withdrawal increases sensitivity to painful stimuli in adult rats. In this study, withdrawal from a single, acute administration of EtOH dose-dependently produced mechanical allodynia and thermal hyperalgesia in postnatal day 7 (P7) ra