Zobrazeno 1 - 10 of 76 pro vyhledávání: '"Jennifer A. Shepherd"'
1
Akademický článek
Microbial rhodoquinone biosynthesis proceeds via an atypical RquA-catalyzed amino transfer from S-adenosyl-L-methionine to ubiquinone
Autor: Trilok Neupane, Lydia R. Chambers, Alexander J. Godfrey, Melina M. Monlux, Evan J. Jacobs, Sophia Whitworth, Jamie E. Spawn, Seo Hee K. Clingman, Kathleen L. Vergunst, Fair M. Niven, James J. Townley, Iris W. Orion, Carly R. Goodspeed, Kathryn A. Cooper, Jeff D. Cronk, Jennifer N. Shepherd, David N. Langelaan
Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-13 (2022)
The RquA protein is required for rhodoquinone biosynthesis; however, its exact function is not yet known. Here, the authors demonstrate that RquA is homologous to SAM-dependent methyltransferases but functions as an aminotransferase using Mn2+ as cof
Externí odkaz: https://doaj.org/article/b2e554daf1fb49c2b8306775749eb555
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2
Akademický článek
Avoiding artefacts in MicroCT imaging of collagen scaffolds: Effect of phosphotungstic acid (PTA)-staining and crosslink density
Autor: Kyung-Ah Kwon, Daniel V. Bax, Jennifer H. Shepherd, Ruth E. Cameron, Serena M. Best
Publikováno v: Bioactive Materials, Vol 8, Iss , Pp 210-219 (2022)
X-ray micro-computed tomography (μ-CT) can be used to provide both qualitative and quantitative information on the structure of three-dimensional (3D) bioactive scaffolds. When performed in a dry state, μ-CT accurately reflects the structure of col
Externí odkaz: https://doaj.org/article/56a137cec150474b81baacf6e7145fea
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3
Akademický článek
Alternative splicing of coq-2 controls the levels of rhodoquinone in animals
Autor: June H Tan, Margot Lautens, Laura Romanelli-Cedrez, Jianbin Wang, Michael R Schertzberg, Samantha R Reinl, Richard E Davis, Jennifer N Shepherd, Andrew G Fraser, Gustavo Salinas
Publikováno v: eLife, Vol 9 (2020)
Parasitic helminths use two benzoquinones as electron carriers in the electron transport chain. In normoxia, they use ubiquinone (UQ), but in anaerobic conditions inside the host, they require rhodoquinone (RQ) and greatly increase RQ levels. We prev
Externí odkaz: https://doaj.org/article/c592d7ec0d4e4dfcb49e098736479870
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4
Akademický článek
Investigation of candidate genes involved in the rhodoquinone biosynthetic pathway in Rhodospirillum rubrum.
Autor: Amanda R M Campbell, Benjamin R Titus, Madeline R Kuenzi, Fernando Rodriguez-Perez, Alysha D L Brunsch, Monica M Schroll, Matthew C Owen, Jeff D Cronk, Kirk R Anders, Jennifer N Shepherd
Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217281 (2019)
The lipophilic electron-transport cofactor rhodoquinone (RQ) facilitates anaerobic metabolism in a variety of bacteria and selected eukaryotic organisms in hypoxic environments. We have shown that an intact rquA gene in Rhodospirillum rubrum is requi
Externí odkaz: https://doaj.org/article/9c4047d86fb743b7bf606157e44e8c82
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5
Akademický článek
Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis
Autor: Courtney W Stairs, Laura Eme, Sergio A Muñoz-Gómez, Alejandro Cohen, Graham Dellaire, Jennifer N Shepherd, James P Fawcett, Andrew J Roger
Publikováno v: eLife, Vol 7 (2018)
Under hypoxic conditions, some organisms use an electron transport chain consisting of only complex I and II (CII) to generate the proton gradient essential for ATP production. In these cases, CII functions as a fumarate reductase that accepts electr
Externí odkaz: https://doaj.org/article/7df347d0d28a4aebb1dcd9bd1626fe87
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7
Revolving doors of tendinopathy: definition, pathogenesis and treatment
Autor: Zafar Ahmad, Jennifer H. Shepherd, Asif Parkar, Neil Rushton
Publikováno v: Postgraduate Medical Journal. 96:94-101
The ultimate cure for the tendon pathology continues to elude current science. Despite great steps in technology, the causation and treatment is still not clear. The number of different theories and treatment modalities in the literature may confuse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05dad404c660c2dc036db07ff54ba83
https://doi.org/10.1136/postgradmedj-2019-136786
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