Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer A. Rutan"'
Autor:
Jennifer A. Rutan, Barbara J. Vilen
Publikováno v:
Immunologic Research. 41:295-309
Systemic lupus erythematosus (SLE) highlights the dangers of dysregulated B cells and the importance of initiating and maintaining tolerance. In addition to central deletion, receptor editing, peripheral deletion, receptor revision, anergy, and indif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c02b45772041526c506e04bebb13c5
https://doi.org/10.1007/s12026-008-8039-8
https://doi.org/10.1007/s12026-008-8039-8
Autor:
Brian P. O’Conner, Stephen H. Clarke, Kara L. Conway, Donna A. Culton, Barbara J. Vilen, Ramiro Diz, Jennifer A. Rutan
Publikováno v:
The Journal of Immunology. 176:790-802
Ab-secreting plasma cells (PCs) are the effectors of humoral immunity. In this study, we describe regulation of autoreactive B cells specific for the ribonucleoprotein Smith (Sm) at an early pre-PC stage. These cells are defined by the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3750a3199003da91da6e19013f149
https://doi.org/10.4049/jimmunol.176.2.790
https://doi.org/10.4049/jimmunol.176.2.790
Publikováno v:
The Journal of Immunology. 175:37-41
Polyclonal B cell activation promotes immunity without the loss of tolerance. Our data show that during activation of the innate immune system, B cell tolerance to Smith Ag Sm is maintained by dendritic cells (DCs) and macrophages (MΦ). TLR4-activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49970990b173b557e8694562f8640852
https://doi.org/10.4049/jimmunol.175.1.37
https://doi.org/10.4049/jimmunol.175.1.37
Autor:
Sun Ah Kang, Jose R. Roques, Stephen H. Clarke, Nikki J. Wagner, Barbara J. Vilen, Kristen N. Krum, Michelle A. Kilmon, Jennifer A. Rutan, Sang-Ryul Lee, Shannon Z. Jones, Andrew J. Monteith
To maintain tolerance, autoreactive B cells must regulate signal transduction from the BCR and TLRs. We recently identified that dendritic cells and macrophages regulate autoreactive cells during TLR4 activation by releasing IL-6 and soluble CD40 lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51389e0a04fd58508e8856a424b17e31
Publikováno v:
International immunology. 19(12)
The B cell antigen receptor (BCR) delivers antigen to the endocytic compartment and transduces signals that regulate the stability of the receptor complex. Previous studies showed that BCR-mediated signal transduction dissociates micro-heavy chain (m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebbb1b703340137d2abe6913dee05e7
https://pubmed.ncbi.nlm.nih.gov/17981794
https://pubmed.ncbi.nlm.nih.gov/17981794