Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Jennifer A. Roth"'
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
Autor:
Noha A. M. Shendy, Melissa Bikowitz, Logan H. Sigua, Yang Zhang, Audrey Mercier, Yousef Khashana, Stephanie Nance, Qi Liu, Ian M. Delahunty, Sarah Robinson, Vanshita Goel, Matthew G. Rees, Melissa A. Ronan, Tingjian Wang, Mustafa Kocak, Jennifer A. Roth, Yingzhe Wang, Burgess B. Freeman, Brent A. Orr, Brian J. Abraham, Martine F. Roussel, Ernst Schonbrunn, Jun Qi, Adam D. Durbin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Chemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, wi
Externí odkaz:
https://doaj.org/article/398968e4bfb8412fb2122ae3a754c4c5
Autor:
Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse J. Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, Ralph A. Neumüller, Barbara Mair, Federico Mauri, Alexandra Popa
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114175- (2024)
Summary: Transcription factors (TFs) are important mediators of aberrant transcriptional programs in cancer cells. In this study, we focus on TF activity (TFa) as a biomarker for cell-line-selective anti-proliferative effects, in that high TFa predic
Externí odkaz:
https://doaj.org/article/cf2194b70a344373b2d1a869bceef1a4
Autor:
James M. McFarland, Brenton R. Paolella, Allison Warren, Kathryn Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, William N. Colgan, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M. Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A. Roth, Todd R. Golub, Aviv Regev, Andrew J. Aguirre, Francisca Vazquez, Aviad Tsherniak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Large-scale screens of chemical and genetic vulnerabilities in cancer are typically limited to simple readouts of cell viability. Here, the authors develop a method for profiling post-perturbation transcriptional responses across large pools of cance
Externí odkaz:
https://doaj.org/article/464481c452404d5080918310ac391162
Autor:
Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray
Publikováno v:
J Med Chem
Transcriptional enhanced associate domain (TEAD) proteins together with their transcriptional coactivator yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) are important transcription factors and cofactors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad6d58cc21b14e6d0f6ee62852637f6
https://doi.org/10.1021/acs.jmedchem.2c01548
https://doi.org/10.1021/acs.jmedchem.2c01548
Autor:
Sarat Chandarlapaty, Nathanael S. Gray, John D. Chodera, Andrew Koff, Violeta Serra, Neal Rosen, Eric S. Fischer, Elisa de Stanchina, Jorge S. Reis-Filho, Marta Palafox, Katherine A. Donovan, Jennifer A. Roth, Melissa M. Ronan, Matthew G. Rees, Andrew S. Boghossian, Bo Liu, Pedram Razavi, Zhiqiang Li, Rei Kudo, Qing Chang, Isabella S. Del Priore, Hong Shao, Jiaye Guo, Baishan Jiang, Qing Li
Supplementary Figure from INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c59cbf947e2a4583d8ecb009dacb67
https://doi.org/10.1158/2159-8290.22540567
https://doi.org/10.1158/2159-8290.22540567
Autor:
Sarat Chandarlapaty, Nathanael S. Gray, John D. Chodera, Andrew Koff, Violeta Serra, Neal Rosen, Eric S. Fischer, Elisa de Stanchina, Jorge S. Reis-Filho, Marta Palafox, Katherine A. Donovan, Jennifer A. Roth, Melissa M. Ronan, Matthew G. Rees, Andrew S. Boghossian, Bo Liu, Pedram Razavi, Zhiqiang Li, Rei Kudo, Qing Chang, Isabella S. Del Priore, Hong Shao, Jiaye Guo, Baishan Jiang, Qing Li
Cyclin-dependent kinases 4 and 6 (CDK4/6) represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eddefc54f2bcf3adf0f3f3b7b424c0
https://doi.org/10.1158/2159-8290.c.6549415
https://doi.org/10.1158/2159-8290.c.6549415
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 8 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034f4932a1dfc60023fb00c753b876b9
https://doi.org/10.1158/0008-5472.22370531.v1
https://doi.org/10.1158/0008-5472.22370531.v1
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Vorinostat is a histone deacetylase inhibitor that induces differentiation, growth arrest, and/or apoptosis of malignant cells both in vitro and in vivo and has shown clinical responses in ∼30% of patients with advanced mycosis fungoides and Séza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0534d95e348157177b3d5bc8200e1ef1
https://doi.org/10.1158/0008-5472.c.6496430
https://doi.org/10.1158/0008-5472.c.6496430
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 1 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad2e5f25d74a2578365f71b01083778
https://doi.org/10.1158/0008-5472.22370555.v1
https://doi.org/10.1158/0008-5472.22370555.v1
Autor:
Victoria M. Richon, Stanley R. Frankel, Marshall E. Kadin, Christopher M. Ware, John F. Reilly, Sophia Randolph, Elizabeth A. Harrington, Xiaoli S. Hou, Susan Korenchuk, Frank Gooden, Lixia Li, Jennifer A. Roth, Jacqueline W. Pierce, Ronald C. Hendrickson, Cloud P. Paweletz, Andrey Loboda, Valeria R. Fantin
Supplementary Figure 7 from Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048b49aadf6d307fb6408e3a831ce2be
https://doi.org/10.1158/0008-5472.22370534
https://doi.org/10.1158/0008-5472.22370534