Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Jennifer A. Pietenpol"'
Autor:
Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop
Externí odkaz:
https://doaj.org/article/2f5efa1be7d149bcb492c236e0e02ed5
Autor:
Brian D. Lehmann, Antonio Colaprico, Tiago C. Silva, Jianjiao Chen, Hanbing An, Yuguang Ban, Hanchen Huang, Lily Wang, Jamaal L. James, Justin M. Balko, Paula I. Gonzalez-Ericsson, Melinda E. Sanders, Bing Zhang, Jennifer A. Pietenpol, X. Steven Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Triple negative breast cancer can be divided into additional subtypes. Here, using omics analyses, the authors show that in the mesenchymal subtype expression of MHC-1 is repressed and that this can be restored by using drugs that target subunits of
Externí odkaz:
https://doaj.org/article/0cee2f33898a4f86bcaa6cb1a2d39df1
Autor:
Lindsay N. Redman-Rivera, Timothy M. Shaver, Hailing Jin, Clayton B. Marshall, Johanna M. Schafer, Quanhu Sheng, Rachel A. Hongo, Kathryn E. Beckermann, Ferrin C. Wheeler, Brian D. Lehmann, Jennifer A. Pietenpol
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Previous studies report that mutant p53 proteins have gain-of-function activities and cause oncogenic phenotypes. Herein, the authors engineered two isogenic epithelial cell lines to express wild-type or missense mutant p53 or be deficient for p53 pr
Externí odkaz:
https://doaj.org/article/10bdca26a8b945f9a336e6d86641208a
Autor:
Clayton B. Marshall, J. Scott Beeler, Brian D. Lehmann, Paula Gonzalez-Ericsson, Violeta Sanchez, Melinda E. Sanders, Kelli L. Boyd, Jennifer A. Pietenpol
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-10 (2021)
Abstract p73 and p63 are members of the p53 family that exhibit overlapping and distinct functions in development and homeostasis. The evaluation of p73 and p63 isoform expression across human tissue can provide greater insight to the functional inte
Externí odkaz:
https://doaj.org/article/48dd852c2c7246bc9d0f0a7898b613f1
Autor:
Gabriela L. Santos Guasch, J Scott Beeler, Clayton B. Marshall, Timothy M. Shaver, Quanhu Sheng, Kimberly N. Johnson, Kelli L. Boyd, Bryan J. Venters, Rebecca S. Cook, Jennifer A. Pietenpol
Publikováno v:
iScience, Vol 8, Iss , Pp 236-249 (2018)
Summary: We report that p73 is expressed in ovarian granulosa cells and that loss of p73 leads to attenuated follicle development, ovulation, and corpus luteum formation, resulting in decreased levels of circulating progesterone and defects in mammar
Externí odkaz:
https://doaj.org/article/79bbd3f5a5444de6bcdc0ceb0648766e
Autor:
Bojana Jovanović, Quanhu Sheng, Robert S. Seitz, Kasey D. Lawrence, Stephan W. Morris, Lance R. Thomas, David R. Hout, Brock L. Schweitzer, Yan Guo, Jennifer A. Pietenpol, Brian D. Lehmann
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Triple negative breast cancer (TNBC) is a heterogeneous disease that lacks unifying molecular alterations that can guide therapy decisions. We previously identified distinct molecular subtypes of TNBC (TNBCtype) using gene express
Externí odkaz:
https://doaj.org/article/0dd8174f05f648f7b930cfdb70942ede
Autor:
Clayton B. Marshall, Deborah J. Mays, J. Scott Beeler, Jennifer M. Rosenbluth, Kelli L. Boyd, Gabriela L. Santos Guasch, Timothy M. Shaver, Lucy J. Tang, Qi Liu, Yu Shyr, Bryan J. Venters, Mark A. Magnuson, Jennifer A. Pietenpol
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2289-2300 (2016)
We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes o
Externí odkaz:
https://doaj.org/article/60e7056b5c994e80bcb344c1e1c7bb07
Autor:
Xi Chen, Joshua A. Bauer, Brian D. Lehmann, William H. Gray, Jiang Li, Yu Shyr, Jennifer A. Pietenpol
Publikováno v:
Cancer Informatics, Vol 2012, Iss 11, Pp 147-156 (2012)
Externí odkaz:
https://doaj.org/article/89f56e18f0424e748722f578a7c77a18
Autor:
Deborah A. Lannigan, George A. O'Doherty, Jennifer A. Pietenpol, David R. Brenin, Miranda E. Sowder, Lejla Pasic, Zachary M. Sandusky, Yu Li, Mingzong Li, J. Preston Campbell, Katarzyna A. Ludwik
Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream MEK-ERK1/2 effector,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1112720a72a8ecae1a317a315623e14
https://doi.org/10.1158/1535-7163.c.6538488.v1
https://doi.org/10.1158/1535-7163.c.6538488.v1
Autor:
Jennifer A. Pietenpol, Melinda E. Sanders, Yu Shyr, Violeta Sánchez, Paula I. Gonzalez-Ericsson, Zhu Li, Douglas B. Johnson, Timothy M. Shaver, Brian D. Lehmann
Fig S1. Frequent focal amplification of DNA proximal to MAP3K8 breakpoint from TCGA tumors and overall survival. Fig S2. Breakpoint spanning reads and resulting protein translation from additional TCGA melanoma tumors with MAP3K8 rearrangements. Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d081948880da72dfcbaea80c3d59d94
https://doi.org/10.1158/1541-7786.22513528
https://doi.org/10.1158/1541-7786.22513528