Validation of a Liquid Biopsy Protocol for Canine BRAFV595E Variant Detection in Dog Urine and Its Evaluation as a Diagnostic Test Complementary to Cytology

Autor: Fabio Gentilini, Christopher J. Palgrave, Michal Neta, Raimondo Tornago, Tommaso Furlanello, Jennifer S. McKay, Federico Sacchini, Maria E. Turba

Publikováno v: Frontiers in Veterinary Science, Vol 9 (2022)

A significant proportion of canine urothelial carcinomas carry the driver valine to glutamic acid variation (V595E) in BRAF kinase. The detection of V595E may prove suitable to guide molecularly targeted therapies and support non-invasive diagnosis o

Externí odkaz: https://doaj.org/article/3bf45319bb3a4b76bed57b0c353ea546

A retrospective study of cases of canine demodicosis submitted to a commercial diagnostic laboratory servicing the United Kingdom and Ireland (2017–2018): Part 1 – Signalment, lesion distribution, treatments, and concurrent diseases

Autor: Pamela A, Kelly, Jennifer S, McKay, David, Maguire, Matthew, Jones, Larry, Roberts, Frank, Powell, Rory, Breathnach

Publikováno v: Research in Veterinary Science. 153:99-104

Canine demodicosis, due to an overpopulation of Demodex spp. mites, remains one of the most common dermatological diseases encountered in small animal practice. The aims of this study were to interrogate submitted histories and diagnostic report resu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c047141d507978cab7633de8ef3dcaa3
https://doi.org/10.1016/j.rvsc.2022.10.022

Data from AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models

Autor: Paul D. Smith, Sue Cartlidge, Mark Cockerill, Richard Jenkins, Samantha Steele, Paul Martin, Jennifer S. McKay, Armelle Logie, Barry R. Davies

Constitutive activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway in human cancers is often associated with mutational activation of BRAF or RAS. MAPK/ERK kinase 1/2 kinases li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5ea77847db5b8626dbd3bb155d54d7
https://doi.org/10.1158/1535-7163.c.6531879

Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure

Autor: Anna S. Cosgrave, Jennifer S. McKay, Vivien Bubb, Richard Morris, John P. Quinn, Thimmasettappa Thippeswamy

Publikováno v: Neurobiology of Disease, Vol 30, Iss 3, Pp 281-292 (2008)

Activity-dependent neuroprotective protein (ADNP) is widely distributed in the cytoplasm of neurons and astrocytes of the hippocampus. Kainic acid (KA)-induced seizures increases neuronal nitric oxide synthase (nNOS) in neurons and inducible NOS (iNO

Externí odkaz: https://doaj.org/article/e4cfd38145c44a5a9c8735db2ca61d6c

The role of Northeast Pacific meltwater events in deglacial climate change

Autor: Maureen H. Walczak, Summer K. Praetorius, Jianghui Du, Jennifer L. McKay, Alan C. Mix, Alan Condron

Publikováno v: Science Advances (2375-2548) (American Association for the Advancement of Science (AAAS)), 2020-02, Vol. 6, N. 9, P. eaay2915 ( 18p.)
Science Advances

Deglacial meltwater input to the North Pacific contributed to abrupt Northern Hemisphere climate events.
Columbia River megafloods occurred repeatedly during the last deglaciation, but the impacts of this fresh water on Pacific hydrography are l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c957f181b66797ff696a6fb7bde9f641
https://archimer.ifremer.fr/doc/00611/72288/