The Relationship between Gene Network Structure and Expression Variation among Individuals and Species.

Autor: Karen E Sears, Jennifer A Maier, Marcelo Rivas-Astroza, Rachel Poe, Sheng Zhong, Kari Kosog, Jonathan D Marcot, Richard R Behringer, Chris J Cretekos, John J Rasweiler, Zoi Rapti

Publikováno v: PLoS Genetics, Vol 11, Iss 8, p e1005398 (2015)

Variation among individuals is a prerequisite of evolution by natural selection. As such, identifying the origins of variation is a fundamental goal of biology. We investigated the link between gene interactions and variation in gene expression among

Externí odkaz: https://doaj.org/article/5567d7d78c9c47f9b5e3eb18fb548fa8

A new mammalian model system for thalidomide teratogenesis: Monodelphis domestica

Autor: Neil Vargesson, Daniel W. Sorensen, Karen E. Sears, Daniel J. Urban, Jennifer A. Maier, Amanda Sackett

Publikováno v: Reproductive Toxicology. 70:126-132

From 1957 to 1962, thalidomide caused birth defects in >10,000 children. While the drug was pulled from the market, thalidomide is currently prescribed to treat conditions including leprosy. As a result, a new generation of babies with thalidomide de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470e0330a01b6f02a66fc12b27df1247
https://doi.org/10.1016/j.reprotox.2017.01.010

Conjoined Twins in a Wild Bat: A Case Report

Autor: Daniel W. Sorensen, Jennifer A. Maier, Karen E. Sears, Nancy B. Simmons, Daniel J. Urban, M. Brock Fenton, Lisa Noelle Cooper

Publikováno v: Acta Chiropterologica. 17:189-192

There are numerous records of conjoined twinning in humans and domesticated animals, but many fewer for wild animals because of the early death of conjoined twins. We here describe the incidental discovery and skeletal anatomy of a wild-caught bat fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dae949c930147218b7c6093969f14d3f
https://doi.org/10.3161/15081109acc2015.17.1.016

Transcriptomic insights into the genetic basis of mammalian limb diversity

Autor: Richard R. Behringer, Xiaoyi Cao, Paige Oboikovitz, Jenny Deng, Sheng Zhong, Anna Dowling, Chris J. Cretekos, Marcelo Rivas-Astroza, John J. Rasweiler, Karen E. Sears, Jennifer A. Maier

Publikováno v: BMC evolutionary biology, vol 17, iss 1
Maier, JA; Rivas-Astroza, M; Deng, J; Dowling, A; Oboikovitz, P; Cao, X; et al.(2017). Transcriptomic insights into the genetic basis of mammalian limb diversity. BMC EVOLUTIONARY BIOLOGY, 17. doi: 10.1186/s12862-017-0902-6. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9nm729ff
BMC Evolutionary Biology

Background From bat wings to whale flippers, limb diversification has been crucial to the evolutionary success of mammals. We performed the first transcriptome-wide study of limb development in multiple species to explore the hypothesis that mammalia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d035a61c88eb5d335725a73a5dee9c28
https://escholarship.org/uc/item/9nm729ff

Patterning and post-patterning modes of evolutionary digit loss in mammals

Autor: Margaret M. Brosnahan, Aysu Uygur, Kimberly L. Cooper, Karen E. Sears, D. F. Antczak, Jennifer A. Maier, Julian A. Skidmore, Karl Stephan Baczkowski, Clifford J. Tabin

Publikováno v: Nature. 511:41-45

A reduction in the number of digits has evolved many times in tetrapods, particularly in cursorial mammals that travel over deserts and plains, yet the underlying developmental mechanisms have remained elusive. Here we show that digit loss can occur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8069036eeb2b36c5aaedc2fb957e137a
https://doi.org/10.1038/nature13496