Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition

Autor: Jennifer A. Hurcombe, Fern Barrington, Micol Marchetti, Virginie M.S. Betin, Emily E. Bowen, Abigail C. Lay, Lan Ni, Lusyan Dayalan, Robert J.P. Pope, Paul T. Brinkkoetter, Martin Holzenberger, Gavin I. Welsh, Richard J.M. Coward

Publikováno v: iScience, Vol 27, Iss 5, Pp 109749- (2024)

Summary: Insulin signaling to the glomerular podocyte via the insulin receptor (IR) is critical for kidney function. In this study we show that near-complete knockout of the closely related insulin-like growth factor 1 receptor (IGF1R) in podocytes i

Externí odkaz: https://doaj.org/article/961bd36ce95841e4b8f27817b6223d15

Insulin directly stimulates VEGF-A production in the glomerular podocyte

Autor: Abigail C Lay, Ángela M. Valverde, Richard J M Coward, Jennifer A. Hurcombe, Peter W. Mathieson, Lorna J Hale, Moin A. Saleem, Beatriz Santamaría, Gavin I. Welsh

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

et al.
Podocytes are critically important for maintaining the integrity of the glomerular filtration barrier and preventing albuminuria. Recently, it has become clear that to achieve this, they need to be insulin sensitive and produce an optimal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb45f5eeab777306150eb7092fcf0898
https://doi.org/10.1152/ajprenal.00548.2012

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function

Autor: Lan Ni, Gavin I. Welsh, Jennifer A. Hurcombe, Susan E. Quaggin, Alexandra F. Barrington, Abigail C Lay, Richard J M Coward, James R. Woodgett

Publikováno v: Hurcombe, J, Lay, A, Ni, L, Barrington, F, Woodgett, J R, Quaggin, S E, Welsh, G & Coward, R 2019, ' Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function ', FASEB BioAdvances, vol. 1, no. 8, pp. 498-510 . https://doi.org/10.1096/fba.2019-00011
FASEB BioAdvances, Vol 1, Iss 8, Pp 498-510 (2019)
FASEB bioAdvances

Podocytes are key cells in maintaining the integrity of the glomerular filtration barrier and preventing albuminuria. Glycogen synthase kinase 3 (GSK3) is a multi‐functional serine/threonine kinase existing as two distinct but related isoforms (α

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c52751cad629d57f6ef2658cdfb637

Podocyte GSK3α is important for autophagy and its loss detrimental for glomerular function.

Autor: Hurcombe, Jennifer A.¹ (AUTHOR), Lay, Abigail C.¹ (AUTHOR), Ni, Lan¹ (AUTHOR), Barrington, Alexandra F.¹ (AUTHOR), Woodgett, Jim R.² (AUTHOR), Quaggin, Susan E.³ (AUTHOR), Welsh, Gavin I.¹ (AUTHOR), Coward, Richard J.¹ (AUTHOR) Richard.Coward@bristol.ac.uk

Publikováno v: FASEB Bioadvances. Aug2019, Vol. 1 Issue 8, p498-510. 13p.