Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jennifer A. Arif"'
Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.
Autor:
Joseph D Planer, Matthew A Hulverson, Jennifer A Arif, Ranae M Ranade, Robert Don, Frederick S Buckner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2977 (2014)
An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease have significant toxicities and suboptimal effectiveness, hence new t
Externí odkaz:
https://doaj.org/article/ba693335c824477fa3bbab1573a1a19d
Autor:
Jennifer A. Arif, Praveen Kumar Suryadevara, Galina I. Lepesheva, Christophe L. M. J. Verlinde, Hari Babu Tatipaka, Frederick S. Buckner, Srinivas Olepu, Neil R. Norcross, Joseph D. Planer, Michael H. Gelb, Kishore Kumar Racherla
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6492-6499
New dialkylimidazole based sterol 14α-demethylase inhibitors were prepared and tested as potential anti- Trypanosoma cruzi agents. Previous studies had identified compound 2 as the most potent and selective inhibitor against parasite cultures. In ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155be679683bf51b94466d8b5c975bf5
https://doi.org/10.1016/j.bmcl.2013.08.015
https://doi.org/10.1016/j.bmcl.2013.08.015
Autor:
Wim G. J. Hol, Tracy L. Arakaki, Natascha Mueller, Christophe L. M. J. Verlinde, Jennifer A. Arif, George T. DeTitta, Wesley C. Van Voorhis, Alberto J. Napuli, Frank Zucker, Erkang Fan, Eric T. Larson, Jenni Ross, Angela Lauricella, Devaraja G. Mudeppa, Joseph R. Luft, J. Robert Gillespie, Frederick S. Buckner, Pradipsinh K. Rathod, Ethan A. Merritt
Publikováno v:
Journal of Molecular Biology. 396:1244-1259
Purine nucleoside phosphorylases and uridine phosphorylases are closely related enzymes involved in purine and pyrimidine salvage, respectively, which catalyze the removal of the ribosyl moiety from nucleosides so that the nucleotide base may be recy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff3d9dfdc3f53bf2dd4ac42dea5e33b
https://doi.org/10.1016/j.jmb.2010.01.013
https://doi.org/10.1016/j.jmb.2010.01.013
Autor:
Ranae M. Ranade, Frederick S. Buckner, Robert Don, Joseph D. Planer, Jennifer A. Arif, Matthew A. Hulverson
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2977 (2014)
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2977 (2014)
An estimated 8 million persons, mainly in Latin America, are infected with Trypanosoma cruzi, the etiologic agent of Chagas disease. Existing antiparasitic drugs for Chagas disease have significant toxicities and suboptimal effectiveness, hence new t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ea0ce6d13da30477654fb5c491d9e6
https://pubmed.ncbi.nlm.nih.gov/25033456
https://pubmed.ncbi.nlm.nih.gov/25033456