Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

Autor: David Horn, Tiago D. Serafim, Leandro Lemgruber, Emma Briggs, Graham Hamilton, Sam Alsford, Jonathan M. Wilkes, Richard McCulloch, Jeremy C. Mottram, Fernando Fernandez-Cortes, Jennifer A. Stortz

Publikováno v: PLoS Pathogens
Stortz, J A, Serafim, T D, Alsford, S, Wilkes, J, Fernandez-Cortes, F, Hamilton, G, Briggs, E, Lemgruber, L, Horn, D, Mottram, J C & McCulloch, R 2017, ' Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei ', PLoS Pathogens, vol. 13, no. 7, e1006477 . https://doi.org/10.1371/journal.ppat.1006477
PLoS Pathogens, Vol 13, Iss 7, p e1006477 (2017)

All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or bypass the resulting DNA lesions. Though many repair pathways are c

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