Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jennifer A Fifita"'
Autor:
Jamie Rae Acosta, Claire Goldsbury, Claire Winnick, Andrew P Badrock, Stuart T Fraser, Angela S Laird, Thomas E Hall, Emily K Don, Jennifer A Fifita, Ian P Blair, Garth A Nicholson, Nicholas J Cole
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e90572 (2014)
FUS mutations can occur in familial amyotrophic lateral sclerosis (fALS), a neurodegenerative disease with cytoplasmic FUS inclusion bodies in motor neurons. To investigate FUS pathology, we generated transgenic zebrafish expressing GFP-tagged wild-t
Externí odkaz:
https://doaj.org/article/2310ea556cbd4b9d9e565e5e97d0b6ed
Autor:
Benjamin G. Trist, Jennifer A. Fifita, Alison Hogan, Natalie Grima, Bradley Smith, Claire Troakes, Caroline Vance, Christopher Shaw, Safa Al-Sarraj, Ian P. Blair, Kay L. Double
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)
Abstract Multiple neurotoxic proteinopathies co-exist within vulnerable neuronal populations in all major neurodegenerative diseases. Interactions between these pathologies may modulate disease progression, suggesting they may constitute targets for
Externí odkaz:
https://doaj.org/article/6009cd789000488891a5da5a25f5909a
Autor:
Sonia Sanz Muñoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-da-Silva, Damian Hernández, Tracey Berg, Jennifer A. Fifita, Natalie Grima, Shu Yang, Ian P. Blair, Garth Nicholson, Anthony L. Cook, Alex W. Hewitt, Alice Pébay, Lezanne Ooi
Publikováno v:
Cells, Vol 9, Iss 9, p 2018 (2020)
The study of neurodegenerative diseases using pluripotent stem cells requires new methods to assess neurodevelopment and neurodegeneration of specific neuronal subtypes. The cholinergic system, characterized by its use of the neurotransmitter acetylc
Externí odkaz:
https://doaj.org/article/89e7ab23e46047a6a0f8fe91d1fcfe64
Autor:
Benjamin G Trist, Sian Genoud, Stéphane Roudeau, Alexander Rookyard, Amr Abdeen, Veronica Cottam, Dominic J Hare, Melanie White, Jens Altvater, Jennifer A Fifita, Alison Hogan, Natalie Grima, Ian P Blair, Kai Kysenius, Peter J Crouch, Asuncion Carmona, Yann Rufin, Stéphane Claverol, Stijn Van Malderen, Gerald Falkenberg, David J Paterson, Bradley Smith, Claire Troakes, Caroline Vance, Christopher E Shaw, Safa Al-Sarraj, Stuart Cordwell, Glenda Halliday, Richard Ortega, Kay L Double
Publikováno v:
Brain 145(9), 3108-3130 (2022). doi:10.1093/brain/awac165
Brain 145(9), 3108 - 3130 (2022). doi:10.1093/brain/awac165
Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in vitro and in transgenic animal models of amyotrophic lat
Aberrant self-assembly and toxicity of wild-type and mutant superoxide dismutase 1 (SOD1) has been widely examined in silico, in vitro and in transgenic animal models of amyotrophic lat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57caec76f6f9bf7ecac8472be9393ab9
https://bib-pubdb1.desy.de/record/481806
https://bib-pubdb1.desy.de/record/481806
Autor:
Kelly L. Williams, Dominic B. Rowe, Natalie Grima, Sandrine Chan Moi Fat, Natalie A. Twine, Roger Pamphlett, Matthew C. Kiernan, Denis C. Bauer, Ian P. Blair, Lyndal Henden, Katharine Y. Zhang, Jennifer A. Fifita, Emily P. McCann
Publikováno v:
Journal of Medical Genetics. 58:87-95
BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with phenotypic and genetic heterogeneity. Approximately 10% of cases are familial, while remaining cases are classified as sporadic. To date, >30 genes and several hu
Autor:
Marianne Hallupp, Colin D. Field, Kelly L. Williams, Emily P. McCann, Garth A. Nicholson, Claire E. Shepherd, John R. Hodges, John Landers, Agnes Luty, William S. Brooks, Thomas Fath, Glenda M. Halliday, Mark F. Bennett, Peter K. Panegyres, Peter R. Schofield, Jennifer A. Fifita, Bradley N. Smith, Ian P. Blair, Janice M. Fullerton, Esmeralda Paric, Neil Rajan, Olivier Piguet, John B.J. Kwok, Jane Hecker, Alex D. Shaw, Cathy L. Short, Melanie Bahlo, Carol Dobson-Stone, Shankaracharya, Audrey Ragagnin, Holly Stefen, Hamideh Shahheydari, Francine Carew-Jones, Elizabeth Thompson, Julie D. Atkin, Zac Chatterton, Peter C. Blumbergs, Simon Topp, Christopher Shaw
Publikováno v:
Brain
Frontotemporal dementia and amyotrophic lateral sclerosis are clinically and pathologically overlapping disorders with shared genetic causes. We previously identified a disease locus on chromosome 16p12.1-q12.2 with genome-wide significant linkage in
Autor:
Denis C. Bauer, Britt A. Berning, Jennifer A. Fifita, Olivier Piguet, Julie D. Atkin, John B.J. Kwok, Adam K. Walker, Sarah E. Freckleton, Alison L. Hogan, Prachi Mehta, Sandrine Chan Moi Fat, Kelly L. Williams, Emily P. McCann, Shu Yang, Dominic B. Rowe, Garth A. Nicholson, Natalie A. Twine, Glenda M. Halliday, Matthew C. Kiernan, Ian P. Blair, Sharlynn Wu, Katharine Y. Zhang, Cyril J. Jagaraj, John R. Hodges, Jasmin Galper, Lyndal Henden, Natalie Grima
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 91:162-171
ObjectiveSince the first report of CHCHD10 gene mutations in amyotrophiclateral sclerosis (ALS)/frontotemporaldementia (FTD) patients, genetic variation in CHCHD10 has been inconsistently linked to disease. A pathological assessment of the CHCHD10 pr
Autor:
Shu Yang, Ian P. Blair, Emily P. McCann, Jasmin Galper, Sharlynn Wu, Sarah E. Freckleton, Fat Scm, Jennifer A. Fifita, Katharine Y. Zhang
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 20:135-159
Background: Ongoing disease gene discoveries continue to drive our understanding of the molecular and cellular mechanisms underlying ALS. Causative genes from 60% of ALS families have been identified using modern genetic techniques, but the causal ge
Autor:
Jennifer A. Fifita, Sandrine Chan Moi Fat, Emily P. McCann, Kelly L. Williams, Natalie A. Twine, Denis C. Bauer, Dominic B. Rowe, Roger Pamphlett, Matthew C. Kiernan, Vanessa X. Tan, Ian P. Blair, Gilles J. Guillemin
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
The essential amino acid tryptophan (TRP) is the initiating metabolite of the kynurenine pathway (KP), which can be upregulated by inflammatory conditions in cells. Neuroinflammation-triggered activation of the KP and excessive production of the KP m
Autor:
Maria D. Villalva, Claire H. Stevens, Alison L. Hogan, Maxinne Watchon, Hannah J. Suddull, Angela S. Laird, Alana De Luca, Ian P. Blair, Flora Cheng, Emily K. Don, Jennilee M. Davidson, Bingyang Shi, Thomas J. Hedl, Shu Yang, Marco Morsch, Albert Lee, Justin J. Yerbury, Sonia Sanz Muñoz, Roger S. Chung, Jennifer A. Fifita, Stephanie L. Rayner, Adam K. Walker, Tyler R. Chapman, Lezanne Ooi
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical