Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer A E, Williams"'
Autor:
Ioana R. Marian, Megan Goff, Jennifer A. E. Williams, Malvika Gulati, Mae Chester-Jones, Anne Francis, Marion Watson, Tonia L. Vincent, Sue Woollacott, Charles Mackworth-Young, Victoria Glover, Dominic Furniss, Matthew Gardiner, Sarah E. Lamb, Katy Vincent, Vicki S. Barber, Joanna Black, Susan J. Dutton, Fiona E. Watt
Publikováno v:
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Background Hand osteoarthritis (OA) is a common condition, causing pain, stiffness and reduced quality of life. Incidence is higher amongst women, particularly around the age of the menopause. Whilst the relationship between sex hormones and
Externí odkaz:
https://doaj.org/article/814a33c795b04098be6e8c16fca98923
Autor:
Jennifer A E Williams, Dimitris Stampoulis, Chloe E Gunter, John Greenwood, Peter Adamson, Stephen E Moss
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161898 (2016)
The purpose of this study was to examine the retinas of mice carrying hemizygous and null double deletions of Cfb-/- and Cfh-/-, and to compare these with the single knockouts of Cfb, Cfh and Cfd. Retinas were isolated from wild type (WT), Cfb-/-/Cfh
Externí odkaz:
https://doaj.org/article/586cb906a5a2469fa4ba8477aac8315b
Autor:
Mae Chester-Jones, Matthew D Gardiner, Sue Woollacott, Charles Mackworth-Young, Katy Vincent, Dominic Furniss, Marion Watson, Victoria Glover, Malvika Gulati, Susan J Dutton, Anne Francis, Sarah E Lamb, Joanna Black, Fiona E. Watt, Ioana R Marian, Megan Goff, Jennifer A E Williams, Tonia L. Vincent, Vicki S Barber
Publikováno v:
Pilot and Feasibility Studies
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-14 (2021)
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-14 (2021)
Background Hand osteoarthritis (OA) is a common condition, causing pain, stiffness and reduced quality of life. Incidence is higher amongst women, particularly around the age of the menopause. Whilst the relationship between sex hormones and OA has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1422249e9e0087baaf8f4d437e0c122d
https://doi.org/10.1186/s40814-021-00869-1
https://doi.org/10.1186/s40814-021-00869-1
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68616 (2013)
We previously reported that aged mice lacking complement factor H (CFH) exhibit visual defects and structural changes in the retina. However, it is not known whether this phenotype is age-related or is the consequence of disturbed development. To add
Externí odkaz:
https://doaj.org/article/4cf1ecfba519403bb3a5d9ae9f925487
Autor:
Jennifer A. E. Williams, Isabelle V. Leefa Chong San, Stephen E. Moss, Ulrike A. Nuber, Gaëlle Prost
Publikováno v:
Biochemical and Biophysical Research Communications. 478:573-579
Podocalyxin (PODXL) is a highly glycosylated and sialylated transmembrane protein that is up-regulated in various types of tumors and whose expression levels positively correlate with tumor grade. We previously found Podxl to be highly expressed in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0010399d189dd515b63100cecd44de
https://doi.org/10.1016/j.bbrc.2016.07.102
https://doi.org/10.1016/j.bbrc.2016.07.102
Autor:
Ulrich F O Luhmann, Koji M. Nishiguchi, Selina A. Azam, Stephen E. Moss, Scott J Robbie, James W B Bainbridge, Mark Basche, Daniel F P Larkin, Robin R. Ali, Alexander J. Smith, John Greenwood, Jennifer A. E. Williams, Yanai Duran, Daniel Kampik, H Han
Publikováno v:
Gene therapy. 24(12)
The retinal pigment epithelium (RPE) interacts closely with photoreceptors to maintain visual function. In degenerative diseases such as Stargardt disease and age-related macular degeneration, the leading cause of blindness in the developed world, RP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d07dc786da962f188ac42dee456470
https://pubmed.ncbi.nlm.nih.gov/29188796
https://pubmed.ncbi.nlm.nih.gov/29188796
Autor:
Jennifer A. E. Williams, Steve P. Watson, Andrew C. Pearce, Stefan Pöhlmann, Yukio Ozaki, Michael G. Tomlinson, Gemma L.J. Fuller, Sheri L. Hanna, Johannes A. Eble, Katsue Suzuki-Inoue
Publikováno v:
Journal of Biological Chemistry. 282:12397-12409
The two lectin receptors, CLEC-2 and Dectin-1, have been shown to signal through a Syk-dependent pathway, despite the presence of only a single YXXL in their cytosolic tails. In this study, we show that stimulation of CLEC-2 in platelets and in two m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b20ff3a09a99f18240973eca2db8aac
https://doi.org/10.1074/jbc.m609558200
https://doi.org/10.1074/jbc.m609558200
Autor:
Hui, Shi, Jennifer A E, Williams, Li, Guo, Dimitrios, Stampoulis, M, Francesca Cordeiro, Stephen E, Moss
Publikováno v:
Apoptosis
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood. Here we have used the 661W cone photoreceptor cell line to ask whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fe05fdd98164e0df10683a889de94ac
https://pubmed.ncbi.nlm.nih.gov/25735751
https://pubmed.ncbi.nlm.nih.gov/25735751
Autor:
Mogens Holst Nissen, Helene B Juel, John Greenwood, Carsten Faber, Jennifer A. E. Williams, Stephen E. Moss
Publikováno v:
Investigative ophthalmologyvisual science. 53(10)
Purpose The complement system is closely linked to the pathogenesis of AMD. Several complement genes are expressed in RPE, and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers increased risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ef435547069b30db7bcaeeeb03bc0f
https://pubmed.ncbi.nlm.nih.gov/22918646
https://pubmed.ncbi.nlm.nih.gov/22918646
Autor:
Albrecht Lommatzsch, John Greenwood, Timothy R. Hughes, Jennifer A. E. Williams, Sarah E. Moss, Daniel Pauleikhoff, Katharina Lueck, Bryan Paul Morgan, Susanne Wasmuth
PURPOSE: There is evidence for complement dysfunction in age-related macular degeneration (AMD). Complement activation leads to formation of the membrane attack complex (MAC), known to assemble on retinal pigment epithelial (RPE) cells. Therefore, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9f23c37f15bbf58d41e1664337b0fd
https://europepmc.org/articles/PMC3178225/
https://europepmc.org/articles/PMC3178225/
