Bacterial persisters in long-term infection: Emergence and fitness in a complex host environment.

Autor: Jennifer A Bartell, David R Cameron, Biljana Mojsoska, Janus Anders Juul Haagensen, Tacjana Pressler, Lea M Sommer, Kim Lewis, Søren Molin, Helle Krogh Johansen

Publikováno v: PLoS Pathogens, Vol 16, Iss 12, p e1009112 (2020)

Despite intensive antibiotic treatment, Pseudomonas aeruginosa often persists in the airways of cystic fibrosis (CF) patients for decades, and can do so without antibiotic resistance development. Using high-throughput screening assays of bacterial su

Externí odkaz: https://doaj.org/article/fdc46894290d4cdfaca1093c8358aed2

Reconstruction of the metabolic network of Pseudomonas aeruginosa to interrogate virulence factor synthesis

Autor: Jennifer A. Bartell, Anna S. Blazier, Phillip Yen, Juliane C. Thøgersen, Lars Jelsbak, Joanna B. Goldberg, Jason A. Papin

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Targeting virulence rather than bacterial growth is less likely to select for antibiotic resistance, but many possible targets function in both processes. Here, the authors reconstruct a genome-scale metabolic network ofP. aeruginosastrain PA14 and u

Externí odkaz: https://doaj.org/article/c931cf703ea8471590b83e82e335a918

MEMOTE for standardized genome-scale metabolic model testing

Autor: Kiran Raosaheb Patil, Jens Nielsen, Vassily Hatzimanikatis, Hyun Uk Kim, Nathan D. Price, Edda Klipp, Parizad Babaei, Lars K. Nielsen, Moritz Emanuel Beber, Sang Yup Lee, Radhakrishnan Mahadevan, Meiyappan Lakshmanan, Lars M. Blank, Jon Olav Vik, Steffen Klamt, Nikolaus Sonnenschein, Saeed Shoaie, Bernhard O. Palsson, Georgios Fengos, Christian Diener, Christopher S. Henry, Andreas Dräger, Janaka N. Edirisinghe, Daniel Machado, Beatriz García-Jiménez, Osbaldo Resendis-Antonio, Hongwu Ma, Peter J. Schaap, Dong-Yup Lee, Wout van Helvoirt, José P. Faria, Judith A. H. Wodke, Adam M. Feist, Siddharth Chauhan, Isabel Rocha, Henning Hermjakob, Qianqian Yuan, Brett G. Olivier, Rahuman S. Malik Sheriff, Markus J. Herrgård, Frank Bergmann, Adil Mardinoglu, Anne Richelle, Filipe Liu, Joana C. Xavier, Maksim Zakhartsev, Paulo Vilaça, Cheng Zhang, Ronan M. T. Fleming, Birgitta E. Ebert, Gregory L. Medlock, Ali Kaafarani, Nathan E. Lewis, Mark G. Poolman, Intawat Nookaew, Jonathan M. Monk, Jason A. Papin, Benjamin Sanchez, Christian Lieven, Matthias König, Juan Nogales, Paulo Maia, Sunjae Lee, Jasper J. Koehorst, Meriç Ataman, Jennifer A. Bartell, Bas Teusink, Kevin Correia, Zachary A. King

Publikováno v: Nature Biotechnology
Lieven, C, Beber, M E, Olivier, B G, Bergmann, F T, Ataman, M, Babaei, P, Bartell, J A, Blank, L M, Chauhan, S, Correia, K, Diener, C, Dräger, A, Ebert, B E, Edirisinghe, J N, Faria, J P, Feist, A M, Fengos, G, Fleming, R M T, García-Jiménez, B, Hatzimanikatis, V, van Helvoirt, W, Henry, C S, Hermjakob, H, Herrgard, M J, Kaafarani, A, Kim, H U, King, Z, Klamt, S, Klipp, E, Koehorst, J J, König, M, Lakshmanan, M, Lee, D-Y, Lee, S Y, Lee, S, Lewis, N E, Liu, F, Ma, H, Machado, D, Mahadevan, R, Maia, P, Mardinoglu, A, Medlock, G L, Monk, J M, Nielsen, J, Nielsen, L K, Nogales, J, Nookaew, I, Palsson, B O, Papin, J A, Patil, K R, Poolman, M, Price, N D, Resendis-Antonio, O, Richelle, A, Rocha, I, Sánchez, B J, Schaap, P J, Malik Sheriff, R S, Shoaie, S, Sonnenschein, N, Teusink, B, Vilaca, P, Vik, J O, Wodke, J A H, Xavier, J C, Yuan, Q, Zakhartsev, M & Zhang, C 2020, ' MEMOTE for standardized genome-scale metabolic model testing ', Nature Biotechnology, vol. 38, no. 3, pp. 272-276 . https://doi.org/10.1038/s41587-020-0446-y
Nature Biotechnology, 38(3), 272-276. Nature Publishing Group
Nature Biotechnology, 38(3), 272-276
Nature Biotechnology 38 (2020) 3
Nature biotechnology 38, 272-276 (2020). doi:10.1038/s41587-020-0446-y
Lieven, C, Beber, M E, Olivier, B G, Bergmann, F T, Ataman, M, Babaei, P, Bartell, J A, Blank, L M, Chauhan, S, Correia, K, Diener, C, Dräger, A, Ebert, B E, Edirisinghe, J N, Faria, J P, Feist, A M, Fengos, G, Fleming, R M T, García-Jiménez, B, Hatzimanikatis, V, van Helvoirt, W, Henry, C S, Hermjakob, H, Herrgård, M J, Kaafarani, A, Kim, H U, King, Z, Klamt, S, Klipp, E, Koehorst, J J, König, M, Lakshmanan, M, Lee, D Y, Lee, S Y, Lee, S, Lewis, N E, Liu, F, Ma, H, Machado, D, Mahadevan, R, Maia, P, Mardinoglu, A, Medlock, G L, Monk, J M, Nielsen, J, Nielsen, L K, Nogales, J, Nookaew, I, Palsson, B O, Papin, J A, Patil, K R, Poolman, M, Price, N D, Resendis-Antonio, O, Richelle, A, Rocha, I, Sánchez, B J, Schaap, P J, Malik Sheriff, R S, Shoaie, S, Sonnenschein, N, Teusink, B, Vilaça, P, Vik, J O, Wodke, J A H, Xavier, J C, Yuan, Q, Zakhartsev, M & Zhang, C 2020, ' MEMOTE for standardized genome-scale metabolic model testing ', Nature Biotechnology, vol. 38, no. 3, pp. 272-276 . https://doi.org/10.1038/s41587-020-0446-y
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Supplementary information is available for this paper at https://doi.org/10.1038/s41587-020-0446-y
Reconstructing metabolic reaction networks enables the development of testable hypotheses of an organisms metabolism under different conditions1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d61d5a36be06a47bc97af59e732f38d
http://europepmc.org/articles/PMC7082222

Omics-based tracking of Pseudomonas aeruginosa persistence in 'eradicated' cystic fibrosis patients

Autor: Jennifer A. Bartell, Søren Molin, Helle Krogh Johansen, Rasmus L. Marvig, Marianne Nielsine Skov, Tacjana Pressler, Lea Mette Madsen Sommer

Publikováno v: Bartell, J A, Sommer, L M, Marvig, R L, Skov, M, Pressler, T, Molin, S & Johansen, H K 2021, ' Omics-based tracking of Pseudomonas aeruginosa persistence in "eradicated" cystic fibrosis patients ', The European Respiratory Journal, vol. 57, no. 4, 2000512 . https://doi.org/10.1183/13993003.00512-2020

WheneverPseudomonas aeruginosais cultured from cystic fibrosis (CF) patient airways, the primary goal is eradication by antibiotic therapy. Success is defined by ≥6 months of negative bacterial airway cultures. However, we suspect thatP. aeruginosa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2286ebca87d682f46a51128646de2fa7
https://curis.ku.dk/portal/da/publications/omicsbased-tracking-of-pseudomonas-aeruginosa-persistence-in-eradicated-cystic-fibrosis-patients(52da2ff6-a158-4d01-a1a7-1603b8100fde).html

Transmission and Antibiotic Resistance of

Autor: Migle, Gabrielaite, Jennifer A, Bartell, Niels, Nørskov-Lauritsen, Tacjana, Pressler, Finn C, Nielsen, Helle K, Johansen, Rasmus L, Marvig

Publikováno v: Journal of Clinical Microbiology

Achromobacter species are increasingly being detected in patients with cystic fibrosis (CF), and this emerging pathogen is associated with antibiotic resistance and more-severe disease outcomes. Nonetheless, little is known about the extent of transm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::061b40ab9b2d911d5f4a4aefae4fae84
https://pubmed.ncbi.nlm.nih.gov/33472899