Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jennifer A, Lockridge"'
Autor:
Ingo Roehl, Stephan Seiffert, Celia Brikh, Jonathan Quinet, Catherine Jamard, Nadine Dorfler, Jennifer A. Lockridge, Lucyna Cova, Andrew Vaillant
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 1-12 (2017)
REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, whil
Externí odkaz:
https://doaj.org/article/93acc5b5558548d5b44948a5ea011ad2
Autor:
Gareth D Healey, Jennifer A Lockridge, Shawn Zinnen, Julian M Hopkin, Ivan Richards, William Walker
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90338 (2014)
Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. H
Externí odkaz:
https://doaj.org/article/e47efed6893641499d5f6df141f92191
Autor:
Jennifer L Lockridge, Xiuxu Chen, Ying Zhou, Deepika Rajesh, Drew A Roenneburg, Subramanya Hegde, Sarah Gerdts, Tan-Yun Cheng, Regan J Anderson, Gavin F Painter, D Branch Moody, William J Burlingham, Jenny E Gumperz
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21701 (2011)
CD1 molecules are glycoproteins that present lipids and glycolipids for recognition by T cells. CD1-dependent immune activation has been implicated in a wide range of immune responses, however, our understanding of the role of this pathway in human d
Externí odkaz:
https://doaj.org/article/c32569081ef64fd7a9252970b7d1d093
Autor:
Lisa M Fox, Daryl G Cox, Jennifer L Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L Trott, Rachel M Ndonye, Natacha Veerapen, Gurdyal S Besra, Amy R Howell, Mark E Cook, Erin J Adams, William H Hildebrand, Jenny E Gumperz
Publikováno v:
PLoS Biology, Vol 7, Iss 10, p e1000228 (2009)
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific aut
Externí odkaz:
https://doaj.org/article/3f5a22c8a7f44061b89d85e01ac33a7a
Autor:
Ying Zhou, Shannon C. Kenney, Christian M. Capitini, Jenny E. Gumperz, Yusof A. Becker, Annette Gendron-Fitzpatrick, Peiman Hematti, Shidong Ma, Jennifer L. Lockridge, William J. Burlingham
Publikováno v:
Biology of Blood and Marrow Transplantation. 19:1310-1322
Chronic graft-versus-host disease (cGVHD) is a significant roadblock to long-term hematopoietic stem cell (HSC) transplantation success. Effective treatments for cGVHD have been difficult to develop, in part because of a paucity of animal models that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb94ca89e63660633f28fccd56bfaaa3
https://doi.org/10.1016/j.bbmt.2013.06.007
https://doi.org/10.1016/j.bbmt.2013.06.007
Autor:
Jennifer A. Lockridge, Ingo Roehl, Celia Brikh, Jonathan Quinet, Andrew Vaillant, Stephan Seiffert, Nadine Dorfler, Lucyna Cova, Catherine Jamard
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 1-12 (2017)
Molecular Therapy: Nucleic Acids, Vol 8, Iss, Pp 1-12 (2017)
REP 2139 is a nucleic acid polymer (NAP) currently under clinical development for chronic hepatitis B (HBV) therapy. This preclinical study investigated different REP 2139 analogs that would display reduced accumulation in the serum and tissues, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dc1b3ff98a7a1969dc905fbaa0810a
https://pubmed.ncbi.nlm.nih.gov/28918011
https://pubmed.ncbi.nlm.nih.gov/28918011
Publikováno v:
Journal of Chromatography B. 835:62-70
The ocular metabolism of an siRNA duplex, SIRNA-027, was examined by ion-pair reversed-phase liquid chromatography (IP-RP-LC) coupled to electrospray ionization mass spectrometry (ESI-MS). The RNA duplex was injected intraocularly into the eyes of Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee270b933d5635982ab71969c0ce503f
https://doi.org/10.1016/j.jchromb.2006.03.008
https://doi.org/10.1016/j.jchromb.2006.03.008
Autor:
Patricia Brown-Augsburger, Jennifer A. Lockridge, Dimple Kamboj, Kathleen M. Hillgren, Xin Min Yue, James McSwiggen
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 34:129-139
Ribozymes are RNA or modified RNA polymers capable of catalyzing cleavage reactions in target strands RNA, and are under development as human therapeutics. Previous methods used for quantitation of nucleic acid polymers in serum or plasma required ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73428bee9e3aea1211bb1bde16fd60a
https://doi.org/10.1016/j.japna.2003.07.002
https://doi.org/10.1016/j.japna.2003.07.002
Autor:
William Walker, Julian M. Hopkin, Jennifer A. Lockridge, Gareth D. Healey, Shawn Zinnen, Ivan Richards
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90338 (2014)
PLoS ONE
PLoS ONE
Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecde221bde224935623bd368fe05623
http://europepmc.org/articles/PMC3937390?pdf=render
http://europepmc.org/articles/PMC3937390?pdf=render
Autor:
Edward S. Boyden, Jianwen Liu, Sanford L. Boye, Benjamin C. Matteo, Jennifer A. Lockridge, Kenneth P. Greenberg, Kimberly A Silka, Gabriel M Gordon, A. Cyrus Arman, Ramesh Janani, Alan Horsager, Shannon E. Boye, Mohammad M. Doroudchi, Alapakkam P. Sampath, William W. Hauswirth
Previous work established retinal expression of channelrhodopsin-2 (ChR2), an algal cation channel gated by light, restored physiological and behavioral visual responses in otherwise blind rd1 mice. However, a viable ChR2-based human therapy must mee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561ea2b3320c26abe16d47e2c142569d
https://europepmc.org/articles/PMC3129568/
https://europepmc.org/articles/PMC3129568/
