Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jennifer A, Cobb"'
Autor:
Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S Taylor, Dinshaw J Patel, Peter M Burgers, Jennifer A Cobb, John H J Petrini
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008422 (2020)
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor su
Externí odkaz:
https://doaj.org/article/388c6d982e6748dbb8481de967c8f5ac
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Mps3 is a SUN (Sad1-UNC-84) domain-containing protein that is located in the inner nuclear membrane (INM). Genetic screens with multiple Mps3 mutants have suggested that distinct regions of Mps3 function in relative isolation and underscore the broad
Externí odkaz:
https://doaj.org/article/9c859dbe34df45c2a0c1634885948a53
Autor:
Maria Laura Sosa Ponce, Mayrene Horta Remedios, Sarah Moradi-Fard, Jennifer A. Cobb, Vanina Zaremberg
Publikováno v:
Journal of Cell Biology. 222
The nuclear envelope (NE) is important in maintaining genome organization. The role of lipids in communication between the NE and telomere regulation was investigated, including how changes in lipid composition impact gene expression and overall nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b702e6983f7763bb05a77e0b62ae2957
https://doi.org/10.1083/jcb.202206061
https://doi.org/10.1083/jcb.202206061
Publikováno v:
Biology Open, Vol 5, Iss 6, Pp 777-785 (2016)
The Smc5/6 complex in Saccharomyces cerevisiae contains six essential non-Smc elements, Nse1-6. With the exception of Nse2 (also known as Mms21), which is an E3 small ubiquitin-like modifier (SUMO) ligase, very little is understood about the role of
Externí odkaz:
https://doaj.org/article/3f7eda7b76d3435fb152954a396672f3
Autor:
Maria Laura Sosa Ponce, Mayrene Horta Remedios, Sarah Moradi-Fard, Jennifer A Cobb, Vanina Zaremberg
The nuclear envelope (NE) is important in maintaining genome organization. The role of lipids in the communication between the NE and telomere silencing was investigated, including how changes in lipid composition impact gene expression and overall n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85f21dcda7e1f0c01257a69ebfe6cff
https://doi.org/10.1101/2022.07.08.499406
https://doi.org/10.1101/2022.07.08.499406
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dfc9d8c95c37b328c9fea3cd5883bfc
https://doi.org/10.1096/fasebj.2022.36.s1.r3271
https://doi.org/10.1096/fasebj.2022.36.s1.r3271
Autor:
Sarah Moradi-Fard, Jessica Sarthi, Mireille Tittel-Elmer, Maxime Lalonde, Emilio Cusanelli, Pascal Chartrand, Jennifer A Cobb
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006268 (2016)
SMC proteins constitute the core members of the Smc5/6, cohesin and condensin complexes. We demonstrate that Smc5/6 is present at telomeres throughout the cell cycle and its association with chromosome ends is dependent on Nse3, a subcomponent of the
Externí odkaz:
https://doaj.org/article/1a27314a42dc442092d523a8246e7405
A double -strand break (DSB) is one of the most deleterious forms of DNA damage. In eukaryotic cells, two main repair pathways have evolved to repair DSBs, homologous recombination (HR) and non-homologous end-joining (NHEJ). HR is the predominant pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372f400d4912363c4b8a0be223dc02ab
https://doi.org/10.1101/2022.02.04.479125
https://doi.org/10.1101/2022.02.04.479125
Publikováno v:
DNA repair. 115
A DNA double strand break (DSB) is primarily repaired by one of two canonical pathways, non-homologous end-joining (NHEJ) and homologous recombination (HR). NHEJ requires no or minimal end processing for ligation, whereas HR requires 5' end resection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2ffe1b7940f7418954b67cdb325c30d
https://pubmed.ncbi.nlm.nih.gov/35537333
https://pubmed.ncbi.nlm.nih.gov/35537333
Publikováno v:
The Journal of biological chemistry. 298(6)
The two major pathways of DNA double-strand break repair, nonhomologous end-joining and homologous recombination, are highly conserved from yeast to mammals. The regulation of 5'-DNA resection controls repair pathway choice and influences repair outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bf617adafca8a37c72c72686c30b08
https://pubmed.ncbi.nlm.nih.gov/35429499
https://pubmed.ncbi.nlm.nih.gov/35429499