Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jennifer Hoyt"'
Autor:
Christian M. Martin, Jennifer Proctor, Patrick O'Hearn, Janid A. Ali, Andre Lescarbeau, Jennifer Hoyt, Jonathan P. DiNitto, Ann M. Rowley, Thomas T. Tibbitts, Catherine A. Evans, Martin R. Tremblay, Tao Liu, Vito J. Palombella, John Soglia, Johan A. Pradeilles, Somarajan J. Nair, Melissa Pink, David G. Winkler, Stanley Goldstein, Quentin Glenadel, Erin L. O’Hearn, Culver Cheung, Erin Brophy, Alfredo C. Castro, Louis Grenier
Publikováno v:
ACS Medicinal Chemistry Letters. 7:862-867
Optimization of isoquinolinone PI3K inhibitors led to the discovery of a potent inhibitor of PI3K-γ (26 or IPI-549) with >100-fold selectivity over other lipid and protein kinases. IPI-549 demonstrates favorable pharmacokinetic properties and robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f2e63c8dbb32a50d02e0a4d22c2564
https://doi.org/10.1021/acsmedchemlett.6b00238
https://doi.org/10.1021/acsmedchemlett.6b00238
Autor:
Alice R. Lim, Pingda Ren, Yi Liu, Jonathan P. DiNitto, Christian C. Fritz, Katti Jessen, Erin Murphy, Vito J. Palombella, Jennifer Lussier, Janid A. Ali, Brian D. Thomas, Kerry White, Lian-Sheng Li, Paul S. Changelian, Melissa Pink, Joi Dunbar, Jennifer Hoyt, Erin Brophy, Bonnie Tillotson, James R. Porter, John Macdougall, David G. Winkler, Christian Rommel, Kerrie Faia, Christian M. Martin, Jennifer L. Proctor, Jeffery L. Kutok
Publikováno v:
Chemistry & Biology. 20:1364-1374
SummaryPhosphoinositide-3 kinase (PI3K)-δ and PI3K-γ are preferentially expressed in immune cells, and inhibitors targeting these isoforms are hypothesized to have anti-inflammatory activity by affecting the adaptive and innate immune response. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5813545be8573cae8ff4e65a9ba3e19c
https://doi.org/10.1016/j.chembiol.2013.09.017
https://doi.org/10.1016/j.chembiol.2013.09.017
Autor:
Joi Dunbar, Margaret A. Read, Joseph D. Manna, Alexander Constan, Alfredo C. Castro, Sherri Smith, Gordon Loewen, John Lee, Somarajan J. Nair, Jennifer Hoyt, Martin R. Tremblay, Julian Adams, Jeanne A. Ferguson, Jens Sydor, Veronica Campbell, Matthew Campbell, Karen McGovern, Brendan Arsenault, Marisa O. Peluso, Jylle Nevejans, Vito J. Palombella, Nigel Whitebread, Grogan Michael John, Kerrie Faia, John Soglia, Bennett Carter
Publikováno v:
Xenobiotica. 43:875-885
1. IPI-926 is a novel semisynthetic cyclopamine derivative that is a potent and selective Smoothened inhibitor that blocks the hedgehog signal transduction pathway. 2. The in vivo clearance of IPI-926 is low in mouse and dog and moderate in monkey. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50620a2c18fbef25785c49cf6a0c9deb
https://doi.org/10.3109/00498254.2013.780671
https://doi.org/10.3109/00498254.2013.780671
Autor:
Jennifer Hoyt
Relations between the United States and Argentina can be best described as a cautious embrace punctuated by moments of intense frustration. Although never the center of U.S.–Latin American relations, Argentina has attempted to create a position of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6922d8a692cc838952107dc7935f69eb
https://doi.org/10.1093/acrefore/9780199329175.013.357
https://doi.org/10.1093/acrefore/9780199329175.013.357
Autor:
Matthew Campbell, Caroline N. Woodward, Jens Sydor, Alfredo C. Castro, James R. Porter, Margaret A. Read, Kerrie Faia, Kerry White, Martin R. Tremblay, Jill Cushing, Julian Adams, Lin-Chen Yu, Mark L. Behnke, Jennifer Hoyt, Vito J. Palombella, Karen McGovern, Somarajan J. Nair, Jeffrey K. Tong, Margit Hagel, Marta Nevalainen, Louis Grenier, Michael Foley
Publikováno v:
Journal of Medicinal Chemistry. 51:6646-6649
Herein is reported the synthesis of a novel class of hedgehog antagonists derived from cyclopamine. The acid sensitive D-ring of cyclopamine was homologated utilizing a sequence of chemoselective cyclopropanation and stereoselective acid-catalyzed re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d0752adc424ed0f2bb4f871b70a4f4
https://doi.org/10.1021/jm8008508
https://doi.org/10.1021/jm8008508
Autor:
Allison W. Dobson, Michael Aschner, Lysette A. Mutkus, Catherine Au, Judy S. Riffle, Jennifer Hoyt Lalli
Publikováno v:
Biological Trace Element Research. 120:248-256
In recent years, both pharmaceutical companies and manufacturing industries have expressed heightened interest in the potential applications of magnetic nanoparticles for therapeutic and technological purposes. Specifically, pharmaceutical companies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f55489068dd35ed56970fbd58ee474
https://doi.org/10.1007/s12011-007-0067-z
https://doi.org/10.1007/s12011-007-0067-z
Autor:
Matthew Campbell, Eddy Tan, Kerry White, Vito J. Palombella, Julian Adams, James M. Conley, Jennifer Hoyt, Martin R. Tremblay, Margit Hagel, Jens Sydor, Jeanne A. Ferguson, Jill Cushing, Alfredo C. Castro, Somarajan J. Nair, Andre Lescarbeau, Melissa Pink, Joseph D. Manna, Grogan Michael John, Margaret A. Read, Caroline N. Woodward, Grace Lin, Mark L. Behnke, Teresa M. Alvarez-Diez, Michael Curtis, Lin-Chen Yu, John R. MacDougall, Karen McGovern, Brian C. Austad
Publikováno v:
Journal of medicinal chemistry. 52(14)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605d8d446344a594f8572549b6a22f4
https://pubmed.ncbi.nlm.nih.gov/19522463
https://pubmed.ncbi.nlm.nih.gov/19522463
Publikováno v:
ACS Symposium Series ISBN: 9780841239432
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca5da6e5c0c6ddce697480da5c18514
https://doi.org/10.1021/bk-2007-0964.ch017
https://doi.org/10.1021/bk-2007-0964.ch017
Autor:
Alan R. Esker, Hyong-Jun Kim, Brent D. Viers, Judy S. Riffle, Jennifer Hoyt Lalli, Jianjun Deng
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 21(5)
Mixtures of a polyhedral oligomeric silsesquioxane, trisilanolisobutyl-POSS, and a polar silicone, poly(dimethyl-co-methylvinyl-co-methyl, 2-diphenyl phosphine oxide ethyl) siloxane (PDMS-PO), spread as Langmuir monolayers at the air/water interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defbd35213656a4548b0d9f38e61337a
https://pubmed.ncbi.nlm.nih.gov/15723488
https://pubmed.ncbi.nlm.nih.gov/15723488
Autor:
Stephen J. Clarson, Michael J. Owen, Marek Cypryk, Julian Chojnowski, Jan Kurjata, James V. Crivello, Myoungsouk Jang, Melissa A. Grunlan, Nam S. Lee, John A. Finlay, James A. Callow, Maureen E. Callow, William P. Weber, Michael W. Backer, John M. Gohndrone, Simon D. Cook, Simeon J. Bones, Raquel Vaquer-Perez, J. B. Baruah, Thomas M. Gädda, Iskender Yilgor, Emel Yilgor, Abhijit V. Jadhav, Siddharth V. Patwardhan, Hyeon Woo Ahn, Craig E. Selby, James O. Stuart, Xiao Kang Zhang, Chung Mien Kuo, Ephraim A. Sheerin, Richard A. Vaia, Steven D. Smith, Brent D. Viers, James E. Mark, Yadagiri Poojari, Aleksandra V. Bystrova, Elene A. Tatarinova, Aziz M. Muzafarov, J. I. Cail, R. F. T. Stepto, Alexander R. Anim-Mensah, William B. Krantz, Julie A. Crowe, Kirill Efimenko, Jan Genzer, Paul M. Zelisko, Amro M. Ragheb, Michael Hrynyk, Michael A. Brook, Hyong-Jun Kim, Jennifer Hoyt Lalli, Judy S. Riffle, Alan R. Esker, Joseph M. Mabry, Ashwani Vij, Wade W. Grabow, Darrell Marchant, Scott T. Iacono, Patrick N. Ruth, Isha Vij, Yusuke Kawakami, Dong Woo Lee, Chits