Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jennifer, Weiszmann"'
Autor:
Jun Zhang, Jamila Gupte, Yan Gong, Jennifer Weiszmann, Yuan Zhang, Ki Jeong Lee, William G. Richards, Yang Li
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 173-183 (2017)
Pharmacological doses of fibroblast growth factor (FGF) 21 effectively normalize glucose, lipid and energy homeostasis in multiple animal models with many benefits translating to obese humans with type 2 diabetes. However, a role for FGF21 in the reg
Externí odkaz:
https://doaj.org/article/2a52f32736c9417ebcea299f61f91c54
FGF21 trafficking in intact human cells revealed by cryo-electron tomography with gold nanoparticles
Autor:
Maia Azubel, Stephen D Carter, Jennifer Weiszmann, Jun Zhang, Grant J Jensen, Yang Li, Roger D Kornberg
Publikováno v:
eLife, Vol 8 (2019)
The fibroblast growth factor FGF21 was labeled with molecularly defined gold nanoparticles (AuNPs), applied to human adipocytes, and imaged by cryo-electron tomography (cryo-ET). Most AuNPs were in pairs about 80 Å apart, on the outer cell surface.
Externí odkaz:
https://doaj.org/article/5be575a83d7a4a18a3a1215ed7dd32df
Autor:
Xinle Wu, Hongfei Ge, Hélène Baribault, Jamila Gupte, Jennifer Weiszmann, Bryan Lemon, Jonitha Gardner, Preston Fordstrom, Jie Tang, Mingyue Zhou, Minghan Wang, Yang Li
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 2, Pp 325-332 (2013)
Elevated triglyceride (TG) and cholesterol levels are risk factors for cardiovascular disease and are often associated with diabetes and metabolic syndrome. Recent reports suggest that fibroblast growth factor (FGF)19 and FGF21 can dramatically impro
Externí odkaz:
https://doaj.org/article/f03db0feb3f14ff497248011fb5d9253
Autor:
Hongfei Ge, Jennifer Weiszmann, Jeff D. Reagan, Jamila Gupte, Helene Baribault, Tibor Gyuris, Jin-Long Chen, Hui Tian, Yang Li
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 797-803 (2008)
GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific in adipocytes. However, the function and signaling properties of GPR81 ar
Externí odkaz:
https://doaj.org/article/763679ce5669428d860903630eebdab3
Autor:
Richard Smith, Amy Duguay, Alice Bakker, Peng Li, Jennifer Weiszmann, Melissa R Thomas, Benjamin M Alba, Xinle Wu, Jamila Gupte, Li Yang, Jennitte Stevens, Agnes Hamburger, Stephen Smith, Jiyun Chen, Renee Komorowski, Kevin W Moore, Murielle M Véniant, Yang Li
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61432 (2013)
The endocrine hormone FGF21 has attracted considerable interest as a potential therapeutic for treating diabetes and obesity. As an alternative to the native cytokine, we generated bispecific Avimer polypeptides that bind with high affinity and speci
Externí odkaz:
https://doaj.org/article/94370a4c5af3418bafae3672e5e4eb24
Autor:
Hongfei Ge, Helene Baribault, Steven Vonderfecht, Bryan Lemon, Jennifer Weiszmann, Jonitha Gardner, Ki Jeong Lee, Jamila Gupte, Paramita Mookherjee, Minghan Wang, Jackie Sheng, Xinle Wu, Yang Li
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33603 (2012)
Diabetes and associated metabolic conditions have reached pandemic proportions worldwide, and there is a clear unmet medical need for new therapies that are both effective and safe. FGF19 and FGF21 are distinctive members of the FGF family that funct
Externí odkaz:
https://doaj.org/article/c8bf8758125a410bb6197b51f966588c
Autor:
Xiaoshan Min, Sheree Johnstone, Wei Wang, Zhulun Wang, Xinchao Yu, Jennifer Weiszmann, William G. Romanow, Stephen T. Thibault, Yang Li
Publikováno v:
Journal of Biological Chemistry. 293:14678-14688
Fibroblast growth factor 21 (FGF21), an endocrine hormone in the FGF family, plays a critical role in regulating metabolic homeostasis and has emerged as a therapeutic target for metabolic diseases, including Type 2 diabetes mellitus. FGF21 functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7cbe79247186146cd43320c77ebf00
https://doi.org/10.1074/jbc.ra118.004343
https://doi.org/10.1074/jbc.ra118.004343
Autor:
Yang Li, Yan Gong, William G. Richards, Jamila Gupte, Ki Jeong Lee, Jennifer Weiszmann, Jun Zhang, Yuan Zhang
Publikováno v:
EBioMedicine, Vol 15, Iss C, Pp 173-183 (2017)
EBioMedicine
EBioMedicine
Pharmacological doses of fibroblast growth factor (FGF) 21 effectively normalize glucose, lipid and energy homeostasis in multiple animal models with many benefits translating to obese humans with type 2 diabetes. However, a role for FGF21 in the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eac277a940d67fc6c694b72e08e4238
https://doi.org/10.1016/j.ebiom.2016.12.016
https://doi.org/10.1016/j.ebiom.2016.12.016
Autor:
Dwight Winters, Todd Hager, Michael Hall, Shanaka Stanislaus, Murielle M. Véniant, Randy Ira Hecht, Chris Spahr, Lei Zhou, Jing Xu, Wei Wang, Yang Li, Junming Yie, Yue-Sheng Li, Liying Deng, Jennifer Weiszmann, Stephen Smith
Publikováno v:
Endocrinology. 158:1314-1327
Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism. Previously, we engineered an Fc fusion FGF21 variant with two mutations, Fc-FGF21(RG), to extend the half-life and reduce aggregation and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e301d1ddf343756228eca215f2028d
https://doi.org/10.1210/en.2016-1917
https://doi.org/10.1210/en.2016-1917
