Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Jennifer, Tickner"'
Autor:
Jacob Kenny, Benjamin H. Mullin, William Tomlinson, Brett Robertson, Jinbo Yuan, Weiwei Chen, Jinmin Zhao, Nathan J. Pavlos, John P. Walsh, Scott G. Wilson, Jennifer Tickner, Grant Morahan, Jiake Xu
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Objectives Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in humans. Currently, there is no m
Externí odkaz:
https://doaj.org/article/aac95cd716db4822bae59acc5d45e557
Autor:
Benjamin H. Mullin, Jennifer Tickner, Kun Zhu, Jacob Kenny, Shelby Mullin, Suzanne J. Brown, Frank Dudbridge, Nathan J. Pavlos, Edward S. Mocarski, John P. Walsh, Jiake Xu, Scott G. Wilson
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Osteoporosis is a complex disease with a strong genetic contribution. A recently published genome-wide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genome-wide significant associat
Externí odkaz:
https://doaj.org/article/5bd008c3bef74c23b6dda461abaf7c6f
Autor:
Shangfu Li, Tianwei He, Depeng Wu, Liangming Zhang, Ruiqiang Chen, Bin Liu, Jinbo Yuan, Jennifer Tickner, An Qin, Jiake Xu, Limin Rong
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Protein kinase C delta (PKC-δ) functions as an important regulator in bone metabolism. However, the precise involvement of PKC-δ in the regulation of osteoclasts remains elusive. We generated an osteoclast specific PKC-δ knockout mouse strain to i
Externí odkaz:
https://doaj.org/article/4802d2df8f1143a2a6ea819696286f07
Autor:
Guoju Hong, Lin Zhou, Xiaorui Han, Ping Sun, Zhenqiu Chen, Wei He, Jennifer Tickner, Leilei Chen, Xuguang Shi, Jiake Xu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Asiatic acid is a triterpenoid compound extracted from a medicinal plant Centella asiatica. It has been used as a highly efficient compound for the treatment of cancer and hyperlipidemia, as well as possessing potential antiinflammatory properties. H
Externí odkaz:
https://doaj.org/article/e4438c948ee84e7db8be4886525d2b85
Autor:
Yu Yuan, Kai Chen, Xi Chen, Chao Wang, Heng Qiu, Zhen Cao, Dezhi Song, Youqiang Sun, Jianmin Guo, Jennifer Tickner, Jiake Xu, Jun Zou
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat o
Externí odkaz:
https://doaj.org/article/b437dde870db4e7abb5e97778254191c
Autor:
Jinbo Yuan, Jennifer Tickner, Benjamin H. Mullin, Jinmin Zhao, Zhiyu Zeng, Grant Morahan, Jiake Xu
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Osteoporosis is a complex condition with contributions from, and interactions between, multiple genetic loci and environmental factors. This review summarizes key advances in the application of genetic approaches for the identification of osteoporosi
Externí odkaz:
https://doaj.org/article/270785c7d7cd428db2d6cb21c79ecf51
Autor:
Edward S. Mocarski, Jacob Kenny, Benjamin H. Mullin, Jennifer Tickner, Scott Wilson, Suzanne J. Brown, Jiake Xu, Nathan J. Pavlos, Kun Zhu, Shelby Mullin, Frank Dudbridge, John P. Walsh
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Genome Biology
Genome Biology
Background Osteoporosis is a complex disease with a strong genetic contribution. A recently published genome-wide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genome-wide significant association signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08794b3310d27dea1f7001a1a65e3ffa
http://link.springer.com/article/10.1186/s13059-020-01997-2
http://link.springer.com/article/10.1186/s13059-020-01997-2
Publikováno v:
Journal of Orthopaedic Translation, Vol 7, Iss C, Pp 120-121 (2016)
Externí odkaz:
https://doaj.org/article/ee13cce250d742be852c0dde1fa9f5f1
Autor:
Jiake Xu, Ren-Xiang Tan, Jun Zou, Yu Yuan, Jennifer Tickner, Kai Chen, Xi Chen, Zhen Cao, Chao Wang, Heng Qiu
Publikováno v:
Journal of Cellular and Molecular Medicine
Imbalance of osteoblast and osteoclast in adult leads to a variety of bone‐related diseases, including osteoporosis. Thus, suppressing the activity of osteoclastic bone resorption becomes the main therapeutic strategy for osteoporosis. Asperpyrone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514f4a18f17af07afc9b10cbc8598385
https://doi.org/10.1111/jcmm.14700
https://doi.org/10.1111/jcmm.14700
Autor:
Ke Xu, Jiake Xu, Te Wang, Haiming Jin, Huazi Xu, Zhen Ye, Qingqing Wang, Heng Qiu, Hao Pan, Jacob Kenny, Feifan Chu, Chao Wang, Jennifer Tickner, Kai Chen, Ziyi Wang
Publikováno v:
Journal of Cellular and Molecular Medicine
Osteoporosis is the most common osteolytic disease characterized by excessive osteoclast formation and resultant bone loss, which afflicts millions of patients around the world. Astilbin, a traditional herb, is known to have anti‐inflammatory, anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e7283fd4707296bfe09d28768e26b5
http://europepmc.org/articles/PMC6850941
http://europepmc.org/articles/PMC6850941