Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma

Autor: Abdelrahman Yousef, Mahmoud Yousef, Saikat Chowdhury, Kawther Abdilleh, Mark Knafl, Paul Edelkamp, Kristin Alfaro-Munoz, Ray Chacko, Jennifer Peterson, Brandon G. Smaglo, Robert A. Wolff, Shubham Pant, Michael S. Lee, Jason Willis, Michael Overman, Sudheer Doss, Lynn Matrisian, Mark W. Hurd, Rebecca Snyder, Matthew H. G. Katz, Huamin Wang, Anirban Maitra, John Paul Shen, Dan Zhao

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Abstract The relevance of KRAS mutation alleles to clinical outcome remains inconclusive in pancreatic adenocarcinoma (PDAC). We conducted a retrospective study of 803 patients with PDAC (42% with metastatic disease) at MD Anderson Cancer Center. Ove

Externí odkaz: https://doaj.org/article/07e4c9e5f98d41abaef00dd9155ae1ad

How frequent is routine use of probiotics in UK neonatal units?

Autor: Justinas Teiserskas, Rachel Hutchinson, Lisa Szatkowski, Claire Caldwell, Katie Taylor, Emilie Seager, Catherine Longley, Rebecca Smith, Brandy Cox, Cheryl Battersby, Helen Lloyd, Aneurin Young, Deborah Davidson, Jennifer Peterson, Emma Williams, Kirti Gupta, Ahmed Mohamed, Paul Fleming, Tal Oryan, Mia Kahvo, Arameh Aghababaie, Janet Berrington, Michelle Fernandes, Neaha Patel, Jessica Farnan, Allan Jenkinson, Bushra Abdul-Malik, Lucinda Winckworth, Kate Costeloe, Christopher Freeman, Katie Evans, Jasmine Taylor, Mary-Rose Ballard, Rhiannon Jones, Rajkumar Dhandayuthapani, Caroline Fraser, James Stevens, Nuala Calder, Amy Grant, Moataz Badawy, Afza Sadiq, Manohar Joishy, Nathan Collicott, Naseem Sharif, Spandana Rupa Madabhushi, G Natasha, Joe McConville, Rhianna Netherton, Lizaveta Collins, Naomi Lin, Kouros Driscoll, Jonathan Talbot, Rosie Roots, Alison Hopper, Camilla James, Shreesh Bhat, Lauren Ferretti, Niha Peshimam, Benjamin Holter, Sion Glaze, Anna Waghorn, Shweta Dixit, Chibuko Ukeje, Shana Irvine, Fergus Harnden, Christine Lim, Neelakshi Ghosh, Eileen Foster, Swati Jha, Joanna O’Sullivan, Evangelia Myttaraki, Shreya Agrawal, Steve Abbey, Abdulhakim Abdurrazaq, Saud Ahmed, Faith Akano, Muhammad Rehan Akhtar, Oghenetekevwe Patrick Akpofure, Myriam Segovia Almiron, Namita Anand, Jessica Archibald, Harriet Aughey, Lynnlette Aung, Thandi Aung, Pramila Bade, Naomi Bell, Andrada Maria Bianu, Catherine Black, Gennie Booth, Karla Buerano, Chinnu Chandran, Shavin Chellen, Ruth Cousins, Leanne Dearman, Alshaimaa Eldeeb, Teim Eyo, Yasin Fatine, Poppy Flanagan, Abhrajit Giri, Saqib Hasan, Craig Haverstock, Jayne Hillier, Kate Hooper, Zoe Howard, Mais Ismail, Matilda Iverson, Sam Jay, Katie Jenkins, Carla Kantyka, Caroline Kargbo, Almutassem Kazkaz, Shelley Knights, Nikoletta Kottarakou, Carianne Lewis, Carys Mangan, Diane McCarter, Aodhan McGillian, Tasneem Modan, Maria Orford, Salil Pradhan, Patrycja Prusak, Ayesha Rahim, Daniel Ratnaraj, Naveed Shahzad, Adwa Shalabi, Claire Strauss, Jane Sundarsingh, Sumit Thankur, Toby Thenat, Alice Unsworth, Carl Van Heyningen, Elena Raluka Vlad

Publikováno v: BMJ Paediatrics Open, Vol 7, Iss 1 (2023)

Objective There is a lack of UK guidance regarding routine use of probiotics in preterm infants to prevent necrotising enterocolitis, late-onset sepsis and death. As practices can vary, we aimed to determine the current usage of probiotics within neo

Externí odkaz: https://doaj.org/article/a4706b9b6ad041239ac057e63d7aeec0

Efficacy and Tolerability of ALK/MET Combinations in Patients With ALK-Rearranged Lung Cancer With Acquired MET Amplification: A Retrospective Analysis

Autor: Ibiayi Dagogo-Jack, MD, Lesli A. Kiedrowski, MS, MPH, Rebecca S. Heist, MD, MPH, Jessica J. Lin, MD, Catherine B. Meador, MD, PhD, Elizabeth A. Krueger, NP, Andrew Do, BS, Jennifer Peterson, BS, Lecia V. Sequist, MD, MPH, Justin F. Gainor, MD, Jochen K. Lennerz, MD, PhD, Subba R. Digumarthy, MD

Publikováno v: JTO Clinical and Research Reports, Vol 4, Iss 8, Pp 100534- (2023)

Introduction: MET amplification is a potentially actionable resistance mechanism in ALK-rearranged (ALK+) lung cancer. Studies describing treatment outcomes of this molecular subgroup are lacking. Methods: We assembled a cohort of patients with ALK+

Externí odkaz: https://doaj.org/article/48f3d6a56b8d4f66bc9f438add97a0a8

Comparison of the performance of a clinical classification tree versus clinical gestalt in predicting sepsis with extended-spectrum beta-lactamase–producing gram-negative rods

Autor: Hayden L. Smith, Mohamed A. Elfeki, Dana Lowry, Rebecca Sabates, Molly Ropte, Katherine R. Sittig, Stephanie Finch, Kristina Braun, William Pruett, Aaron Wasson, Kenna Fischman, Jennifer Peterson, Rossana Rosa

Publikováno v: Antimicrobial Stewardship & Healthcare Epidemiology, Vol 2 (2022)

A clinical decision tree was developed using point-of-care characteristics to identify patients with culture-proven sepsis due to extended-spectrum β-lactamase–producing Enterobacterales (ESBL-PE). We compared its performance with the clinical ges

Externí odkaz: https://doaj.org/article/732dc4046f794accba35d0d4b1775892

Coronavirus Disease 2019 Infection in a Patient Population with Lung Cancer: Incidence, Presentation, and Alternative Diagnostic Considerations

Autor: Andrew J. Piper-Vallillo, MD, Meghan J. Mooradian, MD, Catherine B. Meador, MD, PhD, Beow Y. Yeap, ScD, Jennifer Peterson, BS, Mustafa Sakhi, BS, MS, Andrew Do, BS, Leyre Zubiri, MD, Sara Stevens, NP, Jeanne Vaughn, NP, Kelly Goodwin, NP, Alexander Gavralidis, MD, Henning Willers, MD, Adam Miller, MD, Anna Farago, MD, PhD, Zofia Piotrowska, MD, MHS, Jessica J. Lin, MD, Ibiayi Dagogo-Jack, MD, Inga T. Lennes, MD, MPH, MBA, Lecia V. Sequist, MD, MPH, Jennifer S. Temel, MD, Rebecca S. Heist, MD, Subba Digumarthy, MD, Kerry L. Reynolds, MD, Justin F. Gainor, MD

Publikováno v: JTO Clinical and Research Reports, Vol 2, Iss 1, Pp 100124- (2021)

Introduction: Lung cancer is associated with severe coronavirus disease 2019 (COVID-19) infections. Symptom overlap between COVID-19 and lung cancer may complicate diagnostic evaluation. We aimed to investigate the incidence, symptoms, differential d

Externí odkaz: https://doaj.org/article/899d24b36a34456388b6d820eedce98b