Výsledky vyhledávání - "Jennie R Sims"

Akademický článek

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

Autor: Carolline Ascenção, Jennie R Sims, Alexis Dziubek, William Comstock, Elizabeth A Fogarty, Jumana Badar, Raimundo Freire, Andrew Grimson, Robert S Weiss, Paula E Cohen, Marcus B Smolka

Publikováno v: eLife, Vol 12 (2024)

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of MSCI within the specialized sex body (SB) domain of the nucleus, how they pr

Externí odkaz: https://doaj.org/article/e68bdfb0da04445c9a824600e41463e8

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Akademický článek

Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis

Publikováno v: eLife, Vol 11 (2022)

DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an

Externí odkaz: https://doaj.org/article/57deb83a4c11495681d45121899c60e3

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Akademický článek

Phosphoproteomics of ATR signaling in mouse testes

Autor: Jennie R Sims, Vitor M Faça, Catalina Pereira, Carolline Ascenção, William Comstock, Jumana Badar, Gerardo A Arroyo-Martinez, Raimundo Freire, Paula E Cohen, Robert S Weiss, Marcus B Smolka

Publikováno v: eLife, Vol 11 (2022)

The phosphatidylinositol 3′ kinase (PI3K)‐related kinase ATR is crucial for mammalian meiosis. ATR promotes meiotic progression by coordinating key events in DNA repair, meiotic sex chromosome inactivation (MSCI), and checkpoint-dependent quality

Externí odkaz: https://doaj.org/article/d095669c5d7647b38aa010330d63fada

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Akademický článek

Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways

Autor: Jennie R Sims, Maria C Ow, Mailyn A Nishiguchi, Kyuhyung Kim, Piali Sengupta, Sarah E Hall

Publikováno v: eLife, Vol 5 (2016)

Environmental stress during early development can impact adult phenotypes via programmed changes in gene expression. C. elegans larvae respond to environmental stress by entering the stress-resistant dauer diapause pathway and resume development once

Externí odkaz: https://doaj.org/article/1b80abdd677942baa0f2da7012ba00c9

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Akademický článek

CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma

Autor: Jeffrey C. Martin, Jennie R. Sims, Ajay Gupta, Tamara J. Hagoel, Lingqiu Gao, Miranda L. Lynch, Anna Woloszynska, Thomas Melendy, Jeremy F. Kane, Joseph Kuechle, Joyce E. Ohm

Publikováno v: Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)

Abstract Ewing sarcoma is the second most common bone malignancy in children and adolescents. In recent years, a large body of evidence has emerged that suggests Ewing tumors harbor large amounts of replication stress (RS). CDC7, also known as DDK (D

Externí odkaz: https://doaj.org/article/2a7eb0001dd44a14a8ad4db3dab0f299

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WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe

Autor: Jeffrey C. Martin, Jennie R. Sims, Ajay Gupta, Andrei V. Bakin, Joyce Ellen Ohm

Publikováno v: Cancer Res Commun

Ewing sarcoma is an aggressive childhood cancer for which treatment options remain limited and toxic. There is an urgent need for the identification of novel therapeutic strategies. Our group has recently shown that Ewing cells rely on the S-phase ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802153af516a255cd757f0b84431cae9
https://doi.org/10.1158/2767-9764.crc-22-0130

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