Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jennie N Jeyapalan"'
Autor:
Ayat Lashen, Abdulbaqi Al-Kawaz, Jennie N Jeyapalan, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Michael Toss, Andrew R Green, Nigel P Mongan, Sudha Sharma, Mohammad R Akbari, Emad A Rakha, Srinivasan Madhusudan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 47, Iss , Pp 100957- (2024)
RECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial term
Externí odkaz:
https://doaj.org/article/49f4f85691f14003931c5bd5105aab22
Autor:
Adel Alblihy, Reem Ali, Mashael Algethami, Ahmed Shoqafi, Michael S. Toss, Juliette Brownlie, Natalie J. Tatum, Ian Hickson, Paloma Ordonez Moran, Anna Grabowska, Jennie N. Jeyapalan, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Platinum resistance is a clinical challenge in ovarian cancer. Platinating agents induce DNA damage which activate Mre11 nuclease directed DNA damage signalling and response (DDR). Upregulation of DDR may promote chemotherapy resistance. Her
Externí odkaz:
https://doaj.org/article/97c2fac4721e42b7b207c59b99bc66cf
Autor:
Toby Ryman‐Tubb, Jennifer H. Lothion‐Roy, Veronika M. Metzler, Anna E. Harris, Brian D. Robinson, Albert A. Rizvanov, Jennie N. Jeyapalan, Victoria H. James, Gary England, Catrin S. Rutland, Jenny L. Persson, Lukas Kenner, Mark A. Rubin, Nigel P. Mongan, Simone deBrot
Publikováno v:
Veterinary Medicine and Science, Vol 8, Iss 1, Pp 110-120 (2022)
Abstract Though relatively rare in dogs, prostate cancer (PCa) is the most common non‐cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has
Externí odkaz:
https://doaj.org/article/72e9d9bfc7304f5da0ca9974da17a621
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs tha
Externí odkaz:
https://doaj.org/article/6419108e45f4480eb9fde90ff32de815
Autor:
Adel Alblihy, Ahmed Shoqafi, Michael S. Toss, Mashael Algethami, Anna E. Harris, Jennie N. Jeyapalan, Tarek Abdel-Fatah, Juliette Servante, Stephen Y. T. Chan, Andrew Green, Nigel P. Mongan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopatholo
Externí odkaz:
https://doaj.org/article/56ed86e24ee6429fa04c2441b2232edb
Autor:
Anna E. Harris, Veronika M. Metzler, Jennifer Lothion-Roy, Dhruvika Varun, Corinne L. Woodcock, Daisy B. Haigh, Chantelle Endeley, Maria Haque, Michael S. Toss, Mansour Alsaleem, Jenny L. Persson, Lorraine J. Gudas, Emad Rakha, Brian D. Robinson, Francesca Khani, Laura M. Martin, Jenna E. Moyer, Juliette Brownlie, Srinivasan Madhusudan, Cinzia Allegrucci, Victoria H. James, Catrin S. Rutland, Rupert G. Fray, Atara Ntekim, Simone de Brot, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic
Externí odkaz:
https://doaj.org/article/cdc6c0e64c544575b4a2feb180c39250
Autor:
Catrin S. Rutland, James M. Cockcroft, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Siobhan Simpson, Aziza Alibhai, Clara Bailey, Alyssa C. Ballard-Reisch, Albert A. Rizvanov, Mark D. Dunning, Simone de Brot, Nigel P. Mongan
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
Osteosarcoma (OSA) is an aggressive bone malignancy. Unlike many other malignancies, OSA outcomes have not improved in recent decades. One challenge to the development of better diagnostic and therapeutic methods for OSA has been the lack of well cha
Externí odkaz:
https://doaj.org/article/fd25993690b441c7a30fd4e965862527
Autor:
Mashael A. Algethami, Michael Toss, Juliette Brownlie, Corinne L. Woodcock, Chandar Jaipal, AHMED SHOQAFI, Katia Mesquita, Adel Alblihy, Nigel Mongan, Emad Rakha, Jennie N. Jeyapalan, Srinivasan Madhusudan, Andrew R. Green
Publikováno v:
Cancer Research. 83:P3-05
Unravelling the clinicopathological and functional significance of Replication Protein A (RPA) heterotrimeric complex in sporadic breast cancers Mashael Algethami1, Michael S Toss 1,4, Juliette Brownlie 1, Corinne L Woodcock 1,2, Chandar Jaipal1, Ahm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a685d535a7c5fbf5f6b3a75a357a85f1
https://doi.org/10.1158/1538-7445.sabcs22-p3-05-18
https://doi.org/10.1158/1538-7445.sabcs22-p3-05-18
Autor:
Madhusudan, Adel Alblihy, Reem Ali, Mashael Algethami, Alison A. Ritchie, Ahmed Shoqafi, Shatha Alqahtani, Katia A. Mesquita, Michael S. Toss, Paloma Ordóñez-Morán, Jennie N. Jeyapalan, Lodewijk Dekker, Martina Salerno, Edgar Hartsuiker, Anna M. Grabowska, Emad A. Rakha, Nigel P. Mongan, Srinivasan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10966
The MRE11 nuclease is essential during DNA damage recognition, homologous recombination, and replication. BRCA2 plays important roles during homologous recombination and replication. Here, we show that effecting an MRE11 blockade using a prototypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::46480611ecea84eab38257daed9618ca
Autor:
Mashael Algethami, Michael S. Toss, Corinne L. Woodcock, Chandar Jaipal, Juliette Brownlie, Ahmed Shoqafi, Adel Alblihy, Katia A. Mesquita, Andrew R. Green, Nigel P. Mongan, Jennie N. Jeyapalan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Breast Cancer. 9
Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have evaluated RPA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::546fc63fe8eb737766aaaa1f37eda009
https://doi.org/10.1038/s41523-023-00524-3
https://doi.org/10.1038/s41523-023-00524-3