The anionic amphiphile SDS is an antagonist for the human neutrophil formyl peptide receptor 1

Autor: Huamei Forsman, Claes Dahlgren, Fredrik B. Thorén, Jennie Karlsson

Publikováno v: Biochemical Pharmacology. 80:389-395

The anionic amphiphil sodium dodecyl sulfate (SDS) is commonly used to activate the superoxide-generating NADPH-oxidase complex in cell-free systems, but very little is known about the effects of SDS on intact cells. It was, however, recently shown t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42afd1c6f59cc65fbe988831a0334f32
https://doi.org/10.1016/j.bcp.2010.04.009

The -galactoside binding immunomodulatory lectin galectin-3 reverses the desensitized state induced in neutrophils by the chemotactic peptide f-Met-Leu-Phe: role of reactive oxygen species generated by the NADPH-oxidase and inactivation of the agonist

Autor: Johan Bylund, Claes Dahlgren, Anna Karlsson, Karin Önnheim, Hakon Leffler, Emma Salomonsson, Jennie Karlsson, Åse Björstad, Huamei Forsman

Publikováno v: Glycobiology. 18:905-912

Neutrophils interacting with a chemoattractant gradually become nonresponsive to further stimulation by the same agonist, a process known as desensitization. Receptor desensitization is a highly regulated process that involves different mechanisms de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a34b69da064c2f7988fc536515dda57
https://doi.org/10.1093/glycob/cwn081

A Monocyte-Specific Peptide from Herpes Simplex Virus Type 2 Glycoprotein G Activates the NADPH-Oxidase but Not Chemotaxis through a G-Protein-Coupled Receptor Distinct from the Members of the Formyl Peptide Receptor Family

Autor: François Boulay, Lars Bellner, Jennie Karlsson, Huamei Fu, Anna Karlsson, Claes Dahlgren, Kristina Eriksson

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (9), pp.6080-7
Journal of Immunology, 2007, 179 (9), pp.6080-7

We have recently identified a peptide derived from the secreted portion of the HSV-2 glycoprotein G, gG-2p20, to be proinflammatory. Based on its ability to activate neutrophils and monocytes via the formyl peptide receptor (FPR) to produce reactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095349f83fbc0936aaeba99336da4c67
https://doi.org/10.4049/jimmunol.179.9.6080

The peptide Trp-Lys-Tyr-Met-Val-D-Met activates neutrophils through the formyl peptide receptor only when signaling through the formylpeptde receptor like 1 is blocked

Autor: Johan Bylund, Claes Dahlgren, Huamei Fu, François Boulay, Jennie Karlsson

Publikováno v: Biochemical Pharmacology. 71:1488-1496

Neutrophils express the G protein-coupled N-formyl peptide receptor (FPR) and its homologue FPRL1. The hexapeptide Trp-Lys-Tyr-Met-Val-D-Met-NH2 (WKYMVm) activates HL-60 cells transfected either with FPRL1 or with FPR. The signaling through the stabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2cdcb1bc8e7adbb87a10ebc9e8d37ce
https://doi.org/10.1016/j.bcp.2006.02.010

In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation

Autor: Jennie Karlsson, Charlotta Movitz, Lena Björkman, Claes Dahlgren, Johan Bylund, Karin Christenson, Martina Sundqvist, David P. Speert

Publikováno v: Journal of leukocyte biology. 90(6)

Neutrophils respond to microbial invasion or injury by transmigration from blood to tissue. Transmigration involves cellular activation and degranulation, resulting in altered levels of surface receptors and changed responsiveness to certain stimuli.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19d73a8f6547c09f57f66ca379a2287
https://pubmed.ncbi.nlm.nih.gov/21697259