Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jennie Garcia-Olivares"'
Autor:
Etienne Cartier, Jennie Garcia-Olivares, Eric Janezic, Juan Viana, Michael Moore, Min Landon Lin, Jeffrey L. Caplan, Gonzalo Torres, Yong-Hwan Kim
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The dopamine transporter (DAT) is a plasma membrane protein responsible for the uptake of released dopamine back to the presynaptic terminal and ending dopamine neurotransmission. The DAT is the molecular target for cocaine and amphetamine as well as
Externí odkaz:
https://doaj.org/article/3bfabe0d933a4c218ab1bad971ceaa27
Autor:
Jennie Garcia-Olivares, Delany Torres-Salazar, William A Owens, Tracy Baust, David P Siderovski, Susan G Amara, Jun Zhu, Lynette C Daws, Gonzalo E Torres
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59788 (2013)
Uptake through the Dopamine Transporter (DAT) is the primary mechanism of terminating dopamine signaling within the brain, thus playing an essential role in neuronal homeostasis. Deregulation of DAT function has been linked to several neurological an
Externí odkaz:
https://doaj.org/article/42b8cc8b80754619b13b8ac662609f99
Publikováno v:
CNS Spectrums. 28:235-235
IntroductionMost ADHD treatments are thought to be effective due to augmentation of dopamine (DA) and norepinephrine (NE). Our prior preclinical studies found that the ADHD treatment, viloxazine, may augment serotonin (5-HT) in addition to NE and DA;
Autor:
Robert L. Findling, Stefan Schwabe, Shawn A. Candler, Chungping Yu, Azmi Nasser, Jennie Garcia-Olivares, Jeffrey H. Newcorn, Welton O'Neal
Publikováno v:
CNS Drugs
Viloxazine has a long history of clinical use in Europe as an antidepressant, and has recently been repurposed into an extended-release form for the treatment of attention-deficit/hyperactivity disorder in the USA. An immediate-release formulation wa
Publikováno v:
Journal of Experimental Pharmacology. 12:285-300
Background Viloxazine was historically described as a norepinephrine reuptake inhibitor (NRI). Since NRIs have previously demonstrated efficacy in attention deficit/hyperactivity disorder (ADHD), viloxazine underwent contemporary investigation in the
Autor:
Roberto Rosales-Rojas, Genoveva Rojas, Jeffrey Comer, Ivana Orellana, Jennie Garcia-Olivares, Ariela Vergara-Jaque
Publikováno v:
Journal of Chemical Information and Modeling. 60:3577-3586
Dopamine clearance in the brain is controlled by the dopamine transporter (DAT), a protein residing in the plasma membrane, which drives reuptake of extracellular dopamine into presynaptic neurons. Studies have revealed that the βγ subunits of hete
Publikováno v:
Journal of Experimental Pharmacology
Background Viloxazine was historically described as a norepinephrine reuptake inhibitor (NRI). Since NRIs have previously demonstrated efficacy in attention deficit/hyperactivity disorder (ADHD), viloxazine underwent contemporary investigation in the
Autor:
Jennie Garcia-Olivares, Aurelio Galli, Gonzalo E. Torres, Susan G. Amara, T Baust, Peter J. Hamilton, S S Harris
Publikováno v:
Molecular Psychiatry. 22:1673-1679
The dopamine transporter (DAT) is an important regulator of brain dopamine (DA) homeostasis, controlling the intensity and duration of DA signaling. DAT is the target for psychostimulants—like cocaine and amphetamine—and plays an important role i
Autor:
Jennie Garcia-Olivares, Mary Hongying Cheng, Steven A. Wasserman, Jennifer DiPietro, Ivet Bahar
Publikováno v:
Journal of Biological Chemistry. 292:12471-12482
The human dopamine (DA) transporter (hDAT) is a key regulator of neurotransmission and a target for antidepressants and addictive drugs. Despite the recent resolution of dDAT structures from Drosophila melanogaster, complete understanding of its mech
Autor:
Caitlyn M. Edwards, M Terminel, S S Harris, Michael R. DeChellis-Marks, Macarena Vergara, Jose A. Pino, C D Bassi, Ramón Sotomayor-Zárate, F G Guajardo, Tracy Baust, Gonzalo E. Torres, Jocelyn C. Mauna, Susan G. Amara, Edda Thiels, Edward Castañeda, Jennie Garcia-Olivares
Publikováno v:
Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019)
Translational Psychiatry
Translational Psychiatry
Abnormal levels of dopamine (DA) are thought to contribute to several neurological and psychiatric disorders including drug addiction. Extracellular DA levels are regulated primarily via reuptake by the DA transporter (DAT). Amphetamine, a potent psy