Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jennie G, Pouget"'
Autor:
Mahbod Ebrahimi, Kowsar Teymouri, Cheng C. Chen, Ayeshah G. Mohiuddin, Jennie G. Pouget, Vanessa F. Goncalves, Arun K. Tiwari, Clement C. Zai, James L. Kennedy
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10% dying from suicide. Although genetic components play a significant role in schizophrenia risk,
Externí odkaz:
https://doaj.org/article/fa91f42a67434a70979e8d00c0942ab5
Autor:
Jennie G. Pouget, Lyubov Bryushkova, Emiko Koyama, Clement C. Zai, Trehani M. Fonseka, Daniel Mueller, James L. Kennedy, Joseph H. Beitchman
Publikováno v:
Brain and Behavior, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Background There is growing evidence that inflammation influences mental health. Blood interleukin levels, which regulate inflammation, have been linked to aggression and internalizing behaviors. We performed a hypothesis‐driven genetic st
Externí odkaz:
https://doaj.org/article/6f698c3810694f14b55420ca1f312fac
Autor:
Clement C. Zai, Arun K. Tiwari, Gwyneth C. Zai, Natalie Freeman, Jennie G. Pouget, James Greco, Maria Tampakeras, Sajid A. Shaikh, Deanna Herbert, Heather Emmerson, Sheraz Y. Cheema, Nicole Braganza, Daniel J. Müller, Aristotle N. Voineskos, Gary Remington, James L. Kennedy
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Tardive dyskinesia (TD) is a movement disorder that may develop in schizophrenia patients being treated long-term with antipsychotic medication. TD interferes with voluntary movements and leads to stigma, and can be associated with treatment non-adhe
Externí odkaz:
https://doaj.org/article/33984d43103d4401aacfdc450e8eeebb
Autor:
Alec W. R. Langlois, Ahmed El-Boraie, Jennie G. Pouget, Lisa Sanderson Cox, Jasjit S. Ahluwalia, Koya Fukunaga, Taisei Mushiroda, Jo Knight, Meghan J. Chenoweth, Rachel F. Tyndale
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including functional structural variants (SV) such as gene deletions (CYP2A6*4), duplica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fefaa08f367ed6bac9bf50e0b275975
https://doi.org/10.1038/s10038-023-01148-y
https://doi.org/10.1038/s10038-023-01148-y
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2547
Antipsychotics are the mainstay treatment for schizophrenia. There is large variability between individuals in their response to antipsychotics, both in efficacy and adverse effects of treatment. While the source of interindividual variability in ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9435960c7c7730f31f88d72d2bd34f28
https://pubmed.ncbi.nlm.nih.gov/36068471
https://pubmed.ncbi.nlm.nih.gov/36068471
Autor:
null Jennie G. Pouget, null Lyubov Bryushkova, null Emiko Koyama, null Clement C. Zai, null Trehani M. Fonseka, null Daniel Mueller, null James L. Kennedy, null Joseph H. Beitchman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b028cb81839d19c84118022a8cb5577
https://doi.org/10.1002/brb3.2753/v2/response1
https://doi.org/10.1002/brb3.2753/v2/response1
Autor:
Neal L. Benowitz, Lisa Sanderson Cox, Rachel F. Tyndale, Nicole L. Nollen, Jo Knight, Michiaki Kubo, Caryn Lerman, Meghan J. Chenoweth, Ahmed El-Boraie, Jennie G. Pouget, Taisei Mushiroda, Koya Fukunaga
Publikováno v:
Clin Pharmacol Ther
Clinical pharmacology and therapeutics, vol 110, iss 4
Clinical pharmacology and therapeutics, vol 110, iss 4
The Nicotine Metabolite Ratio (NMR; 3-hydroxycotinine/cotinine), a highly heritable index of nicotine metabolic inactivation by the CYP2A6 enzyme, is associated with numerous smoking behaviors and diseases, as well as unique cessation outcomes. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb05f92a45766c9bdb8624ce823bf4
https://doi.org/10.1002/cpt.2135
https://doi.org/10.1002/cpt.2135
Autor:
Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh
Publikováno v:
PLoS Medicine, Vol 13, Iss 6, p e1001976 (2016)
BackgroundC-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.Methods and findingsWe performed Mendelian randomization (MR) analyses us
Externí odkaz:
https://doaj.org/article/832430b3898d44f4b83d958198e99cbf
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0468549f2fa03e77463d83c63600a6
https://doi.org/10.1007/978-1-0716-2573-6_14
https://doi.org/10.1007/978-1-0716-2573-6_14
Publikováno v:
Molecular Psychiatry. 25:114-130
The complement system is a set of immune proteins involved in first-line defense against pathogens and removal of waste materials. Recent evidence has implicated the complement cascade in diseases involving the central nervous system, including schiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aded0a5880e340f74cd99f231789437e
https://doi.org/10.1038/s41380-019-0479-0
https://doi.org/10.1038/s41380-019-0479-0