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of 2
pro vyhledávání: '"Jennie C. L. Roy"'
Autor:
Zachariah L. McLean, Dadi Gao, Kevin Correia, Jennie C. L. Roy, Shota Shibata, Iris N. Farnum, Zoe Valdepenas-Mellor, Marina Kovalenko, Manasa Rapuru, Elisabetta Morini, Jayla Ruliera, Tammy Gillis, Diane Lucente, Benjamin P. Kleinstiver, Jong-Min Lee, Marcy E. MacDonald, Vanessa C. Wheeler, Ricardo Mouro Pinto, James F. Gusella
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Huntington’s disease (HD) is a dominant neurological disorder caused by an expanded HTT exon 1 CAG repeat that lengthens huntingtin’s polyglutamine tract. Lowering mutant huntingtin has been proposed for treating HD, but genetic modifier
Externí odkaz:
https://doaj.org/article/04c90e61e38c4922b3fb3425418eb127
Autor:
Ricardo Mouro Pinto, Vanessa C. Wheeler, Paula E. Cohen, Antonia G. Vitalo, Marina Kovalenko, Zoe Burch, Jennie C L Roy, Marissa A Andrew, Ed Grabczyk, Anh M Nhu, Eduarda Mota-Silva
Publikováno v:
Nucleic Acids Research
Somatic expansion of the CAG repeat tract that causes Huntington's disease (HD) is thought to contribute to the rate of disease pathogenesis. Therefore, factors influencing repeat expansion are potential therapeutic targets. Genes in the DNA mismatch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b3f76dfd3f35f19d100d3e15042d2d
https://pubmed.ncbi.nlm.nih.gov/33751106
https://pubmed.ncbi.nlm.nih.gov/33751106