Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jenni Viinamäki"'
Autor:
Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Terhi Launiainen, Anne M. Filppula, Jani Katajamäki, Helinä Kahma, Aleksi Tornio, Laura Aurinsalo, Jenni Viinamäki, Marie-Noëlle Paludetto
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 162
We developed an in vitro high-throughput cocktail assay with nine major drug-metabolizing CYP enzymes, optimized for screening of time-dependent inhibition. The method was applied to determine the selectivity of the time-dependent CYP2C8 inhibitors g
Autor:
Minna Lehtisalo, Feng Deng, Jenni E. Keskitalo, Outi Lapatto-Reiniluoto, Aleksi Tornio, Janne T. Backman, Jenni Viinamäki, Taina Jaatinen, Mikko Niemi, Mikko Neuvonen
Publikováno v:
Clinical and Translational Science
Xanthine oxidase inhibitors febuxostat and allopurinol are commonly used in the treatment of gout. Febuxostat inhibits the breast cancer resistance protein (BCRP) in vitro. Rosuvastatin is a BCRP substrate and genetic variability in BCRP markedly aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161e1fdfca31e9a32ae136c1861d4f1f
http://hdl.handle.net/10138/325866
http://hdl.handle.net/10138/325866
Autor:
Päivi J. Miettinen, Kirsi Vaaralahti, Janne T. Backman, H. Huopio, Jorma Toppari, Sirpa Tenhola, Tero Varimo, Raimo Voutilainen, Ella Kohva, Jenni Viinamäki, Taneli Raivio, Matti Hero
Publikováno v:
Human Reproduction (Oxford, England)
STUDY QUESTIONDoes treatment of constitutional delay of growth and puberty (CDGP) in boys with aromatase inhibitor letrozole (Lz) or conventional low-dose testosterone (T) have differing effects on developing seminiferous epithelium?SUMMARY ANSWERAnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1768ab9cfa93b0482389b57313f14c
http://hdl.handle.net/10138/314417
http://hdl.handle.net/10138/314417
Autor:
Janne Raula, Ville Vartiainen, Nurcin Ugur, Luis M. Bimbo, Jenni Viinamäki, Marjukka Myllärniemi, Katri Koli, Esko I. Kauppinen, Eva Sutinen, Janne T. Backman, Emmi I. Joensuu
Publikováno v:
INTERNATIONAL JOURNAL OF PHARMACEUTICS. 544(1):121-128
The aim of this work was to study the antifibrotic effect of pulmonary administration of tilorone to lung fibrosis. L-leucine coated tilorone particles were prepared and their aerosolization properties were analyzed using two dry powder inhalers (Eas
Autor:
Terhi Launiainen, Janne T. Backman, Mikko Neuvonen, Rheem A. Totah, Helinä Kahma, Eric A. Evangelista, Jenni Viinamäki, Anne M. Filppula
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(4)
Clopidogrel acyl-β-d-glucuronide is a mechanism-based inhibitor of cytochrome P450 2C8 in human liver microsomes (HLMs). However, time-dependent inactivation (TDI) of CYP2C8 could not be detected in an earlier study in human recombinant CYP2C8 (Supe
Autor:
Janne T. Backman, Mikko Neuvonen, Terhi Launiainen, Aleksi Tornio, Helinä Kahma, Jenni Viinamäki, Laura Aurinsalo, Anne M. Filppula
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S19
Publikováno v:
Journal of Analytical Toxicology. 39:481-485
Ethylene glycol (EG) is used in antifreeze and other industrial products. It metabolizes to glycolic acid (GA) and oxalic acid (OX) that cause metabolic acidosis and are mainly responsible for the toxicity of EG. During 2010-2014, EG or GA was found
Publikováno v:
Forensic Science International. 249:e7-e11
Kavalactones are a group of compounds found in kava, a beverage or extract prepared from the rhizome of the kava plant (Piper methysticum). Traditionally kava extracts have been used for their anxiolytic and sedative properties. Sales of kava extract
Autor:
Jenni Viinamäki, Ilkka Ojanperä
Publikováno v:
Analytica Chimica Acta. 865:1-7
Quantitative screening for a broad range of drugs in blood is regularly required to assess drug abuse and poisoning within analytical toxicology. Mass spectrometry-based procedures suffer from the large amount of work required to maintain quantitativ
Autor:
Ilkka Ojanperä, Jenni Viinamäki
Publikováno v:
Forensic science international. 267
There is a constant demand for the quantification of drug metabolites within post-mortem toxicology. Especially electrospray ionization-mass spectrometry techniques necessitate that calibration is carried out using primary reference standards due to