Cardiovascular outcome according to renal status in Finnish patients with type 2 diabetes

Autor: Tapio A. Hellman, Ole-Christian Skare, Christopher Lee, Uta Wagner, Johanna Vikkula, Jenni Hällfors, Outi Laatikainen, Mariann I. Lassenius, Kaj Metsärinne

Publikováno v: Diabetes Epidemiology and Management, Vol 8, Iss , Pp 100103- (2022)

Background: : Type 2 diabetes (T2DM) increases the risk for chronic kidney disease (CKD). The objective of this study was to describe the characteristics of patients with T2DM and assess their cardiovascular (CV) and renal outcomes as well as surviva

Externí odkaz: https://doaj.org/article/eaafa7b0d2634e3fa4b58b657eeb0acd

Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.

Autor: Amy E Taylor, Richard W Morris, Meg E Fluharty, Johan H Bjorngaard, Bjørn Olav Åsvold, Maiken E Gabrielsen, Archie Campbell, Riccardo Marioni, Meena Kumari, Jenni Hällfors, Satu Männistö, Pedro Marques-Vidal, Marika Kaakinen, Alana Cavadino, Iris Postmus, Lise Lotte N Husemoen, Tea Skaaby, Tarunveer S Ahluwalia, Jorien L Treur, Gonneke Willemsen, Caroline Dale, S Goya Wannamethee, Jari Lahti, Aarno Palotie, Katri Räikkönen, Aliaksei Kisialiou, Alex McConnachie, Sandosh Padmanabhan, Andrew Wong, Christine Dalgård, Lavinia Paternoster, Yoav Ben-Shlomo, Jessica Tyrrell, John Horwood, David M Fergusson, Martin A Kennedy, Tim Frayling, Ellen A Nohr, Lene Christiansen, Kirsten Ohm Kyvik, Diana Kuh, Graham Watt, Johan Eriksson, Peter H Whincup, Jacqueline M Vink, Dorret I Boomsma, George Davey Smith, Debbie Lawlor, Allan Linneberg, Ian Ford, J Wouter Jukema, Christine Power, Elina Hyppönen, Marjo-Riitta Jarvelin, Martin Preisig, Katja Borodulin, Jaakko Kaprio, Mika Kivimaki, Blair H Smith, Caroline Hayward, Pål R Romundstad, Thorkild I A Sørensen, Marcus R Munafò, Naveed Sattar

Publikováno v: PLoS Genetics, Vol 10, Iss 12, p e1004799 (2014)

We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation anal

Externí odkaz: https://doaj.org/article/e108bc85488b45e6916607f6be734200

Metabolomic signature of angiopoietin-like protein 3 deficiency in fasting and postprandial state

Autor: Lorenzo M. Donini, Matti Jauhiainen, Ilenia Minicocci, Laura D'Erasmo, Peter Würtz, Vesa M. Olkkonen, Jenni Hällfors, Marcello Arca, Emmi Tikkanen, Alessia Di Costanzo, Eleonora Poggiogalle

ObjectiveLoss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with low levels of plasma lipoproteins and decreased coronary artery disease risk. We aimed to determine detailed metabolic effects of genetically-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e970d37181fcc411133caf86d02c7d5f
https://doi.org/10.1101/441857

Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway

Autor: Ida Surakka, Pekka Jousilahti, Jenni Hällfors, Anu Raevuori, Anu Loukola, Pamela A. F. Madden, Richa Gupta, Teemu Palviainen, Jadwiga Buchwald, Samuli Ripatti, Tellervo Korhonen, Jaakko Kaprio

Publikováno v: Addiction Biology

The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for interindividual differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed3eb92fa3e6f9520a6f8e569eeb20e
http://hdl.handle.net/10138/236497

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

Autor: John C. Chambers, J. Wouter Jukema, Rajesh Rawal, Alanna C. Morrison, Paul M. Ridker, Pamela A. F. Madden, Jaakko Kaprio, Gunter Schumann, John M. Starr, Claudia Langenberg, Caterina Barbieri, Cristina Venturini, Leo-Pekka Lyytikäinen, Kenneth J. Mukamal, Dragana Vuckovic, Vilmundur Gudnason, David J. Stott, Evangelos Evangelou, Philippe Froguel, Jaana Laitinen, Christian P. Müller, Paul F. O'Reilly, Christopher P. Nelson, Katharina E. Schraut, Sylvane Desrivières, Lynda M. Rose, Massimo Mangino, Pedro Marques-Vidal, Toniolo Daniela, Hans J. Grabe, Parkyong Song, Anu Loukola, Jenni Hällfors, Nicola Pirastu, Jian'an Luan, Toni-Kim Clarke, Albert V. Smith, Cornelia M. van Duijn, Tianye Jia, Cinzia Sala, Oscar H. Franco, Yongmei Liu, Peter K. Joshi, Robert A. Scott, Helena Schmidt, Marjo-Riitta Järvelin, Sarah R. Preis, Peter Vollenweider, Krista Fischer, Jerome I. Rotter, Alexander Teumer, Ulf Gyllensten, Ani Manichaikul, Brenda W.J.H. Penninx, Stefan Enroth, Alireza Moayyeri, John Whitfield, Anne-Claire Vergnaud, Georgy Bakalkin, Steven A. Kliewer, Niek Verweij, Jaspal S. Kooner, Daniel I. Chasman, Bruce H W Wolffenbuttel, Rozenn N. Lemaitre, Tim D. Spector, Jing Hua Zhao, Weihua Zhang, Zoltán Kutalik, Kenneth Rice, Veronique Vitart, Bing Xu, Anna-Liisa Hartikainen, Niina E. Kaartinen, David J. Mangelsdorf, Jouke-Jan Hottenga, Bing Yu, Loic Yengo, Stella Trompet, Ioanna Tzoulaki, He Gao, Edith Hofer, Nicholas J. Wareham, Takashi Satoh, Nilesh J. Samani, Albert Hofman, Najaf Amin, Hamdi Mbarek, Christian Gieger, Nicholas G. Martin, Yun Liu, Jennifer A. Nettleton, Bruce M. Psaty, Sarah E. Harris, Richard J. Rose, Johan G. Eriksson, Dorret I. Boomsma, Eco J. C. de Geus, André G. Uitterlinden, Andrew C. Heath, Olli T. Raitakari, Chunyu Liu, Terho Lehtimäki, Ian J. Deary, Paul Elliott, Pim van der Harst, Shizuo Akira, Åsa Johansson, Tõnu Esko, Marcelo P. Segura Lepe, Antonietta Robino, Sebastian E. Baumeister, Jari Lahti, James G. Wilson, Saskia Hieber, Barbara Ruggeri, Juho Wedenoja, Eemil Partinen, Reinhold Schmidt, Stéphane Cauchi, Yuri Milaneschi, Tamara B. Harris, Cornelia Huth, Lynne J. Hocking, Daniel Levy, Volker Eulenburg, David P. Strachan

Publikováno v: Proceedings of the National Academy of Sciences of the U.S.A., 113(50), 14372-14377. National Academy of Sciences
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 113(50), 14372-14377. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences, 113(50), 14372-14377
Proceedings of the National Academy of Sciences of the United States of America, 113(50), 14372-14377. National Academy of Sciences
Schumann, G, Liu, C, O'Reilly, P, Gao, H, Song, P, Xu, B, Ruggeri, B, Amin, N, Jia, T, Preis, S, Segura Lepe, M, Akira, S, Barbieri, C, Baumeister, S, Cauchi, S, Clarke, T-K, Enroth, S, Fischer, K, Hällfors, J, Harris, S E, Hieber, S, Hofer, E, Hottenga, J-J, Johansson, Å, Joshi, P K, Kaartinen, N, Laitinen, J, Lemaitre, R, Loukola, A, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Mbarek, H, Milaneschi, Y, Moayyeri, A, Mukamal, K, Nelson, C, Nettleton, J, Partinen, E, Rawal, R, Robino, A, Rose, L, Sala, C, Satoh, T, Schmidt, R, Schraut, K, Scott, R, Smith, A V, Starr, J M, Teumer, A, Trompet, S, Uitterlinden, A G, Venturini, C, Vergnaud, A-C, Verweij, N, Vitart, V, Vuckovic, D, Wedenoja, J, Yengo, L, Yu, B, Zhang, W, Zhao, J H, Boomsma, D I, Chambers, J, Chasman, D I, Daniela, T, de Geus, E, Deary, I, Eriksson, J G, Esko, T, Eulenburg, V, Franco, O H, Froguel, P, Gieger, C, Grabe, H J, Gudnason, V, Gyllensten, U, Harris, T B, Hartikainen, A-L, Heath, A C, Hocking, L, Hofman, A, Huth, C, Jarvelin, M-R, Jukema, J W, Kaprio, J, Kooner, J S, Kutalik, Z, Lahti, J, Langenberg, C, Lehtimäki, T, Liu, Y, Madden, P A F, Martin, N, Morrison, A, Penninx, B, Pirastu, N, Psaty, B, Raitakari, O, Ridker, P, Rose, R, Rotter, J I, Samani, N J, Schmidt, H, Spector, T D, Stott, D, Strachan, D, Tzoulaki, I, van der Harst, P, van Duijn, C M, Marques-Vidal, P, Vollenweider, P, Wareham, N J, Whitfield, J B, Wilson, J, Wolffenbuttel, B, Bakalkin, G, Evangelou, E, Liu, Y, Rice, K M, Desrivières, S, Kliewer, S A, Mangelsdorf, D J, Müller, C P, Levy, D & Elliott, P 2016, ' KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference ', Proceedings of the National Academy of Sciences . https://doi.org/10.1073/pnas.1611243113
Schumann, G, Liu, C, O'Reilly, P, Gao, H, Song, P, Xu, B, Ruggeri, B, Amin, N, Jia, T, Preis, S, Segura Lepe, M, Akira, S, Barbieri, C, Baumeister, S, Cauchi, S, Clarke, T-K, Enroth, S, Fischer, K, Hällfors, J, Harris, S E, Hieber, S, Hofer, E, Hottenga, J-J, Johansson, Å, Joshi, P K, Kaartinen, N, Laitinen, J, Lemaitre, R, Loukola, A, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Mbarek, H, Milaneschi, Y, Moayyeri, A, Mukamal, K, Nelson, C, Nettleton, J, Partinen, E, Rawal, R, Robino, A, Rose, L, Sala, C, Satoh, T, Schmidt, R, Schraut, K, Scott, R, Smith, A V, Starr, J M, Teumer, A, Trompet, S, Uitterlinden, A G, Venturini, C, Vergnaud, A-C, Verweij, N, Vitart, V, Vuckovic, D, Wedenoja, J, Yengo, L, Yu, B, Zhang, W, Zhao, J H, Boomsma, D I, Chambers, J, Chasman, D I, Daniela, T, de Geus, E, Deary, I, Eriksson, J G, Esko, T, Eulenburg, V, Franco, O H, Froguel, P, Gieger, C, Grabe, H J, Gudnason, V, Gyllensten, U, Harris, T B, Hartikainen, A-L, Heath, A C, Hocking, L, Hofman, A, Huth, C, Jarvelin, M-R, Jukema, J W, Kaprio, J, Kooner, J S, Kutalik, Z, Lahti, J, Langenberg, C, Lehtimäki, T, Liu, Y, Madden, P A F, Martin, N, Morrison, A, Penninx, B, Pirastu, N, Psaty, B, Raitakari, O, Ridker, P, Rose, R, Rotter, J I, Samani, N J, Schmidt, H, Spector, T D, Stott, D, Strachan, D, Tzoulaki, I, van der Harst, P, van Duijn, C M, Marques-Vidal, P, Vollenweider, P, Wareham, N J, Whitfield, J B, Wilson, J, Wolffenbuttel, B, Bakalkin, G, Evangelou, E, Liu, Y, Rice, K M, Desrivières, S, Kliewer, S A, Mangelsdorf, D J, Müller, C P, Levy, D & Elliott, P 2016, ' KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14372-14377 . https://doi.org/10.1073/pnas.1611243113
Schumann, G, Liu, C, O'Reilly, P, Gao, H, Song, P, Xu, B, Ruggeri, B, Amin, N, Jia, T, Preis, S R, Hottenga, J J, Mbarek, H, Boomsma, D I, de Geus, E J C, Penninx, B W J H, Bakalkin, G, Evangelou, E, Liu, Y, Rice, K M, Desrivieres, S, Kliewer, S A, Mangelsdorf, D J, Müller, C P, Levy, D & Elliott, P 2016, ' KLB is associated with alcohol drinking, and its gene product B-Klotho is necessary for FGF21 regulation of alcohol preference ', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 50, pp. 14372-14377 . https://doi.org/10.1073/pnas.1611243113
Proceedings of the National Academy of Sciences of the United States of America, 113(50), 14372-14377. National Acad Sciences

Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e9cb2fddb393aed254e7de3ee70b7d
http://hdl.handle.net/10044/1/43194