Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jenni E. Keskitalo"'
Autor:
Minna Lehtisalo, Feng Deng, Jenni E. Keskitalo, Outi Lapatto-Reiniluoto, Aleksi Tornio, Janne T. Backman, Jenni Viinamäki, Taina Jaatinen, Mikko Niemi, Mikko Neuvonen
Publikováno v:
Clinical and Translational Science
Xanthine oxidase inhibitors febuxostat and allopurinol are commonly used in the treatment of gout. Febuxostat inhibits the breast cancer resistance protein (BCRP) in vitro. Rosuvastatin is a BCRP substrate and genetic variability in BCRP markedly aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161e1fdfca31e9a32ae136c1861d4f1f
http://hdl.handle.net/10138/325866
http://hdl.handle.net/10138/325866
Autor:
Oliver Zolk, Martin F. Fromm, Pertti J. Neuvonen, Kaisa J. Kurkinen, Jenni E. Keskitalo, Mikko Niemi
Publikováno v:
Clinical Pharmacology & Therapeutics. 86:197-203
The ABCG2 c.421C>A single-nucleotide polymorphism (SNP) was determined in 660 healthy Finnish volunteers, of whom 32 participated in a pharmacokinetic crossover study involving the administration of 20 mg atorvastatin and rosuvastatin. The frequency
Publikováno v:
Clinical Pharmacology & Therapeutics. 84:457-461
ABCB1 haplotypes were determined in 534 healthy Finnish volunteers, of whom 24 participated in a pharmacokinetic study on simvastatin and atorvastatin. The frequencies of occurrence of haplotypes c.1236T-c.2677T-c.3435T and c.1236C-c.2677G-c.3435C we
Autor:
Kathrin Klein, Matthias Schwab, Mikko Niemi, Ulrich M. Zanger, Pertti J. Neuvonen, Jenni E. Keskitalo, Stephan Riedmaier, Ute Hofmann
Publikováno v:
Clinical pharmacology and therapeutics. 87(1)
The response to statins shows large interpatient variability. Atorvastatin δ-lactone is pharmacologically inactive but has been associated with toxicity. We investigated the role of UDP-glucuronosyltransferases (UGTs) in atorvastatin lactonization.
Autor:
Kaisa J. Kurkinen, Janne T. Backman, Pertti J. Neuvonen, Jenni E. Keskitalo, Mikko Niemi, Mikko Neuvonen
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • ABCB1 genotype affects the pharmacokinetics and cholesterol-lowering effects of simvastatin and atorvastatin. • The cholesterol-lowering effect of fluvastatin has been associated with ABCB1 genotype, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c629cdae83c49635ab72c30b8dee9105
https://europepmc.org/articles/PMC2767284/
https://europepmc.org/articles/PMC2767284/