UPR Responsive Genes Manf and Xbp1 in Stroke

Autor: Helike Lõhelaid, Jenni E. Anttila, Hock-Kean Liew, Kuan-Yin Tseng, Jaakko Teppo, Vassilis Stratoulias, Mikko Airavaara

Publikováno v: Frontiers in Cellular Neuroscience, Vol 16 (2022)

Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with the cellular stress resulting in massive cell death, which cann

Externí odkaz: https://doaj.org/article/dfba186cdb954e66bf46b80054a1efba

UPR Responsive Genes

Autor: Helike, Lõhelaid, Jenni E, Anttila, Hock-Kean, Liew, Kuan-Yin, Tseng, Jaakko, Teppo, Vassilis, Stratoulias, Mikko, Airavaara

Publikováno v: Frontiers in cellular neuroscience. 16

Stroke is a devastating medical condition with no treatment to hasten recovery. Its abrupt nature results in cataclysmic changes in the affected tissues. Resident cells fail to cope with the cellular stress resulting in massive cell death, which cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::688220f522fcf157bf5a6b2a74a6f153
https://pubmed.ncbi.nlm.nih.gov/35783104

Molecular profile of the rat peri-infarct region four days after stroke: Study with MANF

Autor: Jenni E. Anttila, Jaakko Teppo, Anu Vaikkinen, Mikko Airavaara, Olli-Pekka Smolander, Risto Kostiainen, Brandon K. Harvey, Kert Mätlik, Päivi Pöhö, Vassilis Stratoulias

The peri-infarct region after ischemic stroke is the anatomical location for many of the endogenous recovery processes, and the molecular events in the peri-infarct region remain poorly characterized. In this study, we examine the molecular profile o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79646a2ee425c9460135d35bc3f95be8
http://hdl.handle.net/10138/316267

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

Autor: Jenni E. Anttila, Mikko Airavaara, Raimo K. Tuominen, Konstantin Khodosevich, Maria Lindahl, Kuan-Yin Tseng, Andrii Domanskyi

Publikováno v: Molecular Therapy
Tseng, K-Y, Anttila, J E, Khodosevich, K, Tuominen, R K, Lindahl, M, Domanskyi, A & Airavaara, M 2018, ' MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke ', Molecular therapy : the journal of the American Society of Gene Therapy, vol. 26, no. 1, pp. 238-255 . https://doi.org/10.1016/j.ymthe.2017.09.019

Cerebral ischemia activates endogenous reparative processes, such as increased proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) and migration of neural progenitor cells (NPCs) toward the ischemic area. However, this reparati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b0a4bedc47de89bf0c67d1e224cd54
https://doi.org/10.1016/j.ymthe.2017.09.019

Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats

Autor: Lowella V. Fortuno, Susanne Bäck, Bruce T. Hope, YaJun Zhang, C. Grace Yeh, Jenni E. Anttila, Alexander F. Hoffman, Leslie R. Whitaker, Charles E. Spivak, Emily J. Heathward, Pyry Koivula, Carlos A. Mejias-Aponte, Mikko Airavaara, Suzanne M. Underhill, Heather A. Baldwin, F. Kent Hamra, Andrii Domanskyi, Carl R. Lupica, Brandon K. Harvey, Julie C. Necarsulmer, Morgan D. Spencer, James Pickel, Christopher T. Richie, Susan G. Amara, Lamarque M. Coke

Publikováno v: Neuron. 102(1)

Historically, the rat has been the preferred animal model for behavioral studies. Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. Here, we have developed several transgeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b964f845c1ad8e3b45a7e2bb78fe86
https://pubmed.ncbi.nlm.nih.gov/30792150