Výsledky vyhledávání - "Jenni A. Punt"

Autor: Jenni A. Punt

Once alerted by the innate immune system to the presence of a pathogen or a cellular abnormality, the adaptive immune system responds by activating and expanding antigen-specific B and T lymphocytes. This chapter focuses specifically on the activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6fd9aa71fb20a91703fa4375488107f4
https://doi.org/10.1016/b978-0-12-394296-8.00004-x

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GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation

Autor: Jenni A. Punt, Nicole R. Cunningham, Vassily I. Kutyavin, Whitney A. Reid, Thomas C. Beck, Emily Hinchcliff

Publikováno v: International immunology. 23(11)

Although mature T cells divide and differentiate when they receive strong TCR stimulation, most immature CD4+CD8+ thymocytes die. The molecular basis for this marked difference in response is not known. Observations that TCR-stimulated CD4+CD8+ thymo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a431320408e9e46ec4584e70f3090212
https://pubmed.ncbi.nlm.nih.gov/21937454

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A Novel Nr4a1GFP Reporter System Reveals That Nr4a1 Expression Identifies Long-Term Hematopoietic Stem Cells

Autor: Nicole R. Cunningham, Stephen G. Emerson, Ruben Land, Matthew Gross, Sophie Eiger, Jenni A. Punt, Russell Garrett, Shwetha Manjunath, Trevor Barlowe

Publikováno v: Blood. 118:2339-2339

Abstract 2339 Recent studies have highlighted the importance of the NR4A nuclear receptor family (Nur77 (Nr4a1), Nurr1 (Nr4a3), Nor1 (Nr4a2)) in the regulation of hematopoiesis. In murine models, NR4A gene deficiencies lead to aberrant proliferation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b425c956855de244e8872c58f6af9301
https://doi.org/10.1182/blood.v118.21.2339.2339

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IFNs Upregulate Sca-1 and Block Proliferation in Murine Hematopoietic Stem and Progenitor Cells

Autor: Nicole R. Cunningham, Jenni A. Punt, Carson Wills, Stephen G. Emerson, Kaitlyn Shank, Alevtina Domashenko, Russell Garrett, Yusup Shin

Publikováno v: Blood. 118:3394-3394

Abstract 3394 Hematopoietic stem cells (HSC) replenish the cellular components of the blood throughout life by a homeostatic process in which the majority of HSCs remain quiescent while a small percentage enter the cell cycle to either self-review or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bc37ccb06d012c2c1f9135c63e830a1
https://doi.org/10.1182/blood.v118.21.3394.3394

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Differential Regulation of Expression of the Anti-Leukemogenic Orphan Nuclear Receptor Nur77 (nr4a1) In HSCs, CLPs, and CMPs

Autor: Yusup Shin, Matthew Gross, Shwetha Manjunath, Jenni A. Punt, Stephen G. Emerson, Ruben Land, Russell Garrett

Publikováno v: Blood. 116:4782-4782

Abstract 4782 The molecular basis for the balance between self-renewal and differentiation that regulates hematopoietic stem cell (HSC) development is poorly understood. Recent studies suggest that levels of expression of the orphan nuclear hormone r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eba658a7959fe78339fb5b4a187a9093
https://doi.org/10.1182/blood.v116.21.4782.4782

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