Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jenney Liu"'
Autor:
Fanyan Meng, Ling Wu, Lun Dong, Allison V. Mitchell, C. James Block, Jenney Liu, Haijun Zhang, Qing Lu, Won-min Song, Bin Zhang, Wei Chen, Jiani Hu, Jian Wang, Qifeng Yang, Maik Hüttemann, Guojun Wu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Triple-negative breast cancer is an aggressive form of the disease. Here, the authors identify EGFL9 as a mediator of metastasis in TNBC through interactions with cMET.
Externí odkaz:
https://doaj.org/article/389b81394bda4d2382c09db9e9b68fc5
Autor:
Thomas H. Sanderson, Joseph M. Wider, Icksoo Lee, Christian A. Reynolds, Jenney Liu, Bradley Lepore, Reneé Tousignant, Melissa J. Bukowski, Hollie Johnston, Alemu Fite, Sarita Raghunayakula, John Kamholz, Lawrence I. Grossman, Karin Przyklenk, Maik Hüttemann
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract The interaction of light with biological tissue has been successfully utilized for multiple therapeutic purposes. Previous studies have suggested that near infrared light (NIR) enhances the activity of mitochondria by increasing cytochrome c
Externí odkaz:
https://doaj.org/article/d38358554de345238b2771e0cebf73a7
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88322 (2014)
Radiotherapy is the treatment of choice for solid tumors including pancreatic cancer, but the effectiveness of treatment is limited by radiation resistance. Resistance to chemotherapy or radiotherapy is associated with reduced mitochondrial respirati
Externí odkaz:
https://doaj.org/article/268df36991ee4e0f9f53392da23b2f73
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Method Descriptions Molecular modeling and computational studies Enzyme expression and purification. In vitro enzymatic assays and Ki determinations In vivo efficacy trials with MIA PaCa-2 pancreatic cancer xenografts. Cytochrome c oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc08fe908fb7939bc9f8ad0ffe9cbc1
https://doi.org/10.1158/1535-7163.22505520
https://doi.org/10.1158/1535-7163.22505520
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4253307c713eb35fa04c2ec4fe8823be
https://doi.org/10.1158/1535-7163.c.6538104.v1
https://doi.org/10.1158/1535-7163.c.6538104.v1
Autor:
Larry H. Matherly, Aleem Gangjee, Charles E. Dann, Zhanjun Hou, Jing Li, Joshua D. Rabinowitz, Lisa Polin, Maik Hüttemann, Seongho Kim, Juiwanna Kushner, Kathryn White, Sijana H. Dzinic, Carrie O'Connor, Adrianne Wallace-Povirk, Jenney Liu, Josephine Frühauf, Xun Bao, Changwen Ning, Arpit Doshi, Md. Junayed Nayeen, Jennifer Wong-Roushar, Jade M. Katinas, Gregory S. Ducker, Khushbu Shah, Aamod S. Dekhne
Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1
https://doi.org/10.1158/1535-7163.22505523.v1
Autor:
Jessica Dragotto, Siddhesh Aras, Robert P. Erickson, Maria Teresa Fiorenza, Maik Hüttemann, Neeraja Purandare, Lawrence I. Grossman, Jenney Liu
Publikováno v:
Mitochondrion. 51:15-21
It has long been known that there is decreased mitochondrial function in several tissues of Niemann–Pick C1 model mice and cultured cells. These defects contribute to the accumulation of Reactive Oxygen Species (ROS) and tissue damage. It is also w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded14b005d0ac1a1c142f83722363bf3
https://doi.org/10.1016/j.mito.2019.12.003
https://doi.org/10.1016/j.mito.2019.12.003
Autor:
Aamod S. Dekhne, Khushbu Shah, Gregory S. Ducker, Jade M. Katinas, Jennifer Wong-Roushar, Md. Junayed Nayeen, Arpit Doshi, Changwen Ning, Xun Bao, Josephine Frühauf, Jenney Liu, Adrianne Wallace-Povirk, Carrie O'Connor, Sijana H. Dzinic, Kathryn White, Juiwanna Kushner, Seongho Kim, Maik Hüttemann, Lisa Polin, Joshua D. Rabinowitz, Jing Li, Zhanjun Hou, Charles E. Dann, Aleem Gangjee, Larry H. Matherly
Publikováno v:
Molecular Cancer Therapeutics. 22:287-287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77add014c1f088eaf12406ee9ad8e4d9
https://doi.org/10.1158/1535-7163.mct-22-0766
https://doi.org/10.1158/1535-7163.mct-22-0766
Autor:
Qing Lu, Fanyan Meng, Jenney Liu, Jian Wang, Guojun Wu, C. James Block, Qifeng Yang, Won-Min Song, Wei Chen, Allison V. Mitchell, Jiani Hu, Ling Wu, Bin Zhang, Maik Hüttemann, Lun Dong, Haijun Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
The molecular mechanisms driving metastatic progression in triple-negative breast cancer (TNBC) patients are poorly understood. In this study, we demonstrate that epidermal growth factor-like 9 (EGFL9) is significantly upregulated in basal-like breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dc2a719cf25c8f418038a9e9cb7031
http://link.springer.com/article/10.1038/s41467-019-13034-3
http://link.springer.com/article/10.1038/s41467-019-13034-3
Autor:
Wenxi Yu, Maik Hüttemann, Shyamalagauri Jadhav, Michael Salsaa, Jenney Liu, Miriam L. Greenberg, Bianca Pereira
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these mechanisms, we determined the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94eef53bfbd7ac90379484d4cd391016
https://doi.org/10.1038/s41598-020-68725-5
https://doi.org/10.1038/s41598-020-68725-5