Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Jennette A. Sakoff"'
Autor:
Jennifer R. Baker, Jayne Gilbert, Nicholas S. O’Brien, Cecilia C. Russell, Adam McCluskey, Jennette A. Sakoff
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
We previously reported on the interaction of 10-chloro-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one (10-Cl-BBQ) with the Aryl hydrocarbon Receptor (AhR) and selective growth inhibition in breast cancer cell lines. We now report on a library
Externí odkaz:
https://doaj.org/article/827e77419dfb41b8b950e383c0565803
Autor:
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2181 (2024)
Kinetically inert platinum(IV) complexes are a chemical strategy to overcome the impediments of standard platinum(II) antineoplastic drugs like cisplatin, oxaliplatin and carboplatin. In this study, we reported the syntheses and structural characteri
Externí odkaz:
https://doaj.org/article/895f80b1275247969fe711f6d4a6beef
Autor:
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2780 (2022)
Four platinum(IV) prodrugs incorporating a biotin moiety to selectively target cancer cells were synthesised, characterised, and their biological activity assessed. All complexes exhibited exceptional in vitro cytotoxicity against a panel of cancer c
Externí odkaz:
https://doaj.org/article/2cc6b9c95c964c2893856eb9badd2173
Autor:
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Publikováno v:
Molecules, Vol 27, Iss 20, p 7120 (2022)
A new series of cytotoxic platinum(IV) complexes (1–8) incorporating halogenated phenylacetic acid derivatives (4-chlorophenylacetic acid, 4-fluorophenylacetic acid, 4-bromophenylacetic acid and 4-iodophenylacetic acid) were synthesised and charact
Externí odkaz:
https://doaj.org/article/c9af94e27190424db7547603cd8e96f5
Autor:
Angelico D. Aputen, Maria George Elias, Jayne Gilbert, Jennette A. Sakoff, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich-Wright
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10471 (2022)
The DNA-alkylating derivative chlorambucil was coordinated in the axial position to atypical cytotoxic, heterocyclic, and non-DNA coordinating platinum(IV) complexes of type, [PtIV(HL)(AL)(OH)2](NO3)2 (where HL is 1,10-phenanthroline, 5-methyl-1,10-p
Externí odkaz:
https://doaj.org/article/0e8d8ac6cdd448829b6049a002158c29
Autor:
David M. Campkin, Yuna Shimadate, Barbara Bartholomew, Paul V. Bernhardt, Robert J. Nash, Jennette A. Sakoff, Atsushi Kato, Michela I. Simone
Publikováno v:
Molecules, Vol 27, Iss 11, p 3447 (2022)
Tetrachlorinated phthalimide analogues bearing a boron-pinacolate ester group were synthesised via two synthetic routes and evaluated in their glycosidase modulating and anticancer properties, with a view to use them in boron neutron capture therapy
Externí odkaz:
https://doaj.org/article/1e9051f89d4a4d5ab3a4f314e45666c7
Autor:
Hong Ngoc Thuy Pham, Jennette A. Sakoff, Quan V. Vuong, Michael C. Bowyer, Christopher J. Scarlett
Publikováno v:
Data in Brief, Vol 21, Iss , Pp 1033-1036 (2018)
This data article indicates the in vitro cytotoxicity of kaempferol and gallic acid across different cancer cell lines including A2780 (ovarian), H460 (lung), A431 (skin), MIA PaCa-2 (pancreas), Du145 (prostate), HT29 (colon), MCF-7 (breast), BE2-C (
Externí odkaz:
https://doaj.org/article/488e60942e694675a25143254a9044e0
Autor:
Aleen Khoury, Jennette A. Sakoff, Jayne Gilbert, Kieran F. Scott, Shawan Karan, Christopher P. Gordon, Janice R. Aldrich-Wright
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 787 (2022)
Platinum(IV) prodrugs of the [Pt(PL)(AL)(COXi)(OH)]2+ type scaffold (where PL is 1,10-phenanthroline or 5,6-dimethyl-1,10-phenanthroline, AL is 1S,2S-diaminocyclohexane, and COXi is a COX inhibitor, either indomethacin or aspirin) were synthesised an
Externí odkaz:
https://doaj.org/article/c31dd43af5ca43f9a31bcc238b4bd6ec
Autor:
Peter J. Cossar, Mohammed K. Abdel-Hamid, Cong Ma, Jennette A. Sakoff, Trieu N. Trinh, Christopher P. Gordon, Peter J. Lewis, Adam McCluskey
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3839-3857 (2017)
Externí odkaz:
https://doaj.org/article/18507ec09c4e43c9ac4c112c6de0fa28
Autor:
Azadeh Ghods, Jayne Gilbert, Jennifer R. Baker, Cecilia C. Russell, Jennette A. Sakoff, Adam McCluskey
Publikováno v:
Royal Society Open Science, Vol 5, Iss 4 (2018)
Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and focused library approach using a microwave-assisted Suzuki coupling gave 32 bolinaquinone analogues with good-to-excelle
Externí odkaz:
https://doaj.org/article/bd690ca96af544e88fe7b7d47bfae898